K0HSB2 (K0HSB2_CAMJU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase EMBL AFU42635.1
EC=1.1.1.42 EMBL AFU42635.1

Gene names

ORF Names:

A911_02585 EMBL AFU42635.1

Organism

Campylobacter jejuni subsp. jejuni PT14 EMBL AFU42635.1

Taxonomic identifier

1201032 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter jejuni › Campylobacter jejuni subsp. jejuni

Protein attributes

Sequence length	734 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL AFU42635.1
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	129 – 136	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	345	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	539	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	543	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	142	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	538	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	252	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	415	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	K0HSB2 [UniParc]. Last modified November 28, 2012. Version 1. Checksum: 0EF7141282A4ED03	FASTA	734	82,386
	10 20 30 40 50 60 MQITYTLTDE SPALATYSFL PIVKAFLSRA HIGVKTSDIS LSGRILATFS EYLKEEQRCE 70 80 90 100 110 120 DALELLGELV KRSDANLIKT PNISASIPQL KAAIKELQDK GYMLPNYPDE PKNDEELQIK 130 140 150 160 170 180 TKYQKVLGSA VNPVLRQGNS DRRSTKAVKD YAKNNPYRVV EFNPNSKTRV SYMKEGDFFS 190 200 210 220 230 240 NEKAVLIDQD CVANIEFTSV DGKKEILKEG LKLEKNEILD ATFMDVQKLQ EFYAKEIKAS 250 260 270 280 290 300 KDDDVLFSLH LKATMMKVSD PILFGYAVKV FFKELFIEFQ DEFEKLGINP NNGLSELLSK 310 320 330 340 350 360 IENSSKKDEI LKKYNEILAK SADISMVNSD KGITNLHVPS DVIVDASMPA MLKNGARLWD 370 380 390 400 410 420 KEGKEKDTNA VIPDQTYATI YEAVIEDLHK NGTLNPSKLG SVSNVGLMAK KAQEYGSHDK 430 440 450 460 470 480 TFVAKEEGTF KIVSNGKVLL EHKVRKGDIY RANQAKFDAV LNWIDLGIER SELSGAEAIF 490 500 510 520 530 540 WLDSKRASNK IMITLVQNRL KEKGKNVAIL TPKEACLRSL ELIREGKDVI SITGNVLRDY 550 560 570 580 590 600 LTDLFPILEL GTSAKMLSVV PMLNGGAMFE TGAGGSAPKQ VEQLVEENHL RWDSLGEFLA 610 620 630 640 650 660 LQASLEFYVN KCGNHKAKVL AECLDEAIGE WLENNKAPSR KVKEDDNRTS HFYLAMYFAN 670 680 690 700 710 720 HLARQASDME LQSFFKDIAL ELSSNEEKIR AEFNDAQGVK VDLGGYYKFD DEKANKIMRP 730 SATFNAILEK IGQR

References

[1]	"Genome sequence of universal bacteriophage host strain Campylobacter jejuni subspecies jejuni PT14." Brathwaite K.J., Siringan P., Moreton J., Wilson R., Connerton I.F. Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: PT14 EMBL AFU42635.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003871 Genomic DNA. Translation: AFU42635.1.
RefSeq	YP_006857608.1. NC_018709.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AFU42635; AFU42635; A911_02585.
GeneID	13790217.
KEGG	cjp:A911_02585.
Phylogenomic databases
KO	K00031.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

K0HSB2_CAMJU

Accession

Primary (citable) accession number: K0HSB2

Entry history

Integrated into UniProtKB/TrEMBL:	November 28, 2012
Last sequence update:	November 28, 2012
Last modified:	April 3, 2013
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)