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K0HS37 (K0HS37_PROAA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
ORF Names:PAC1_11940 EMBL AFU42124.1
OrganismPropionibacterium acnes C1 [Complete proteome] EMBL AFU42124.1
Taxonomic identifier1234380 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. HAMAP-Rule MF_00047

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain101 – 308208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding135 – 19056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2621Magnesium or manganese By similarity HAMAP-Rule MF_00047
Metal binding2751Magnesium or manganese By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
K0HS37 [UniParc].

Last modified November 28, 2012. Version 1.
Checksum: 2A21BF044D02C02B

FASTA31532,764
        10         20         30         40         50         60 
MLQPVVVLAG GLSHQRDISL KSGRTVAQAL RRVGHEVVEA DIDSALIETL RANDGAVVFP 

        70         80         90        100        110        120 
MLHGGLGENG ALLEVLQLMG IPYVGSSPAT CRISFDKSIA SRAVAAAGIV TPQQVALPHD 

       130        140        150        160        170        180 
VFRELGAQTV MRSIAEKFGL PVIVKPARGG SSLGVTKVDG VDDLPQAVAN AYAYDDMVVV 

       190        200        210        220        230        240 
EEFIVGTELA IGMITTSEGT RVLPAVEIRP VGGVYDYSAM YTGGETRLTA PADISDTAAQ 

       250        260        270        280        290        300 
TATAMARVVQ KELDFSGISR VDAIVDESGR PVFLEAGAAP GMTATSLVPV AMKAAGLDLG 

       310 
EVCSRLVDDV ARNHG 

« Hide

References

[1]"Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient."
Minegishi K., Aikawa C., Furukawa A., Watanabe T., Nakano T., Ogura Y., Ohtsubo Y., Kurokawa K., Hayashi T., Maruyama F., Nakagawa I., Eishi Y.
Genome Announc. 1:E00016-12(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C1 EMBL AFU42124.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003877 Genomic DNA. Translation: AFU42124.1.
RefSeqYP_006852355.1. NC_018707.1.

3D structure databases

ProteinModelPortalK0HS37.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFU42124; AFU42124; PAC1_11940.
GeneID13785044.
KEGGpacc:PAC1_11940.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK0HS37_PROAA
AccessionPrimary (citable) accession number: K0HS37
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: February 19, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)