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K0HN77

- K0HN77_PROAA

UniProt

K0HN77 - K0HN77_PROAA

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Protein

Alanine racemase

Gene
PAC1_11655
Organism
Propionibacterium acnes C1
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei137 – 1371Substrate By similarityUniRule annotation
Active sitei266 – 2661Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei314 – 3141Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:PAC1_11655Imported
OrganismiPropionibacterium acnes C1Imported
Taxonomic identifieri1234380 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000006305: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliK0HN77.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K0HN77-1 [UniParc]FASTAAdd to Basket

« Hide

MPRCPSPSHA IIDLSAIAAN LAVVRKRAGD RKVLFAVKAD AYGHGAVEVS    50
RYVEKHRYAD WLAVATVAEG QELVEAGITL PILKLSPAHP WDMDAAITSG 100
IRLTVVDFDT LEAVSKAAVR LGITAKIHIA VDSGMGRIGL RPECLAELTA 150
AADRAKGVEV EGVFTHLPIS DVPEGAEFTR REIDTFMTAV SLIETHRGPF 200
PLVHLANSGA ILGHDLGKTS MVRAGIVGYG YDPNPHADRA DLHPALSWIS 250
HVTFVKTVSV GDTIGYGRTW TASETTKIAT VPVGYADGLS RGLSNKGHVL 300
IRGSVHPIVG RICMDQFMVD LGPDSNVTVG DEVVLIGTQE DETLTADDMA 350
ELLGTISYEI TCAISKRVDR YWVGQ 375
Length:375
Mass (Da):40,162
Last modified:November 28, 2012 - v1
Checksum:iC56EBAE89371B404
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003877 Genomic DNA. Translation: AFU42067.1.
RefSeqiYP_006852298.1. NC_018707.1.

Genome annotation databases

EnsemblBacteriaiAFU42067; AFU42067; PAC1_11655.
GeneIDi13784339.
KEGGipacc:PAC1_11655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003877 Genomic DNA. Translation: AFU42067.1 .
RefSeqi YP_006852298.1. NC_018707.1.

3D structure databases

ProteinModelPortali K0HN77.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFU42067 ; AFU42067 ; PAC1_11655 .
GeneIDi 13784339.
KEGGi pacc:PAC1_11655.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient."
    Minegishi K., Aikawa C., Furukawa A., Watanabe T., Nakano T., Ogura Y., Ohtsubo Y., Kurokawa K., Hayashi T., Maruyama F., Nakagawa I., Eishi Y.
    Genome Announc. 1:E00016-12(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C1Imported.

Entry informationi

Entry nameiK0HN77_PROAA
AccessioniPrimary (citable) accession number: K0HN77
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 3, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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