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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Peripheral membrane protein SAAS annotation
  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 144GP120InterPro annotationAdd BLAST112
Domaini148 – 526GP120InterPro annotationAdd BLAST379
Domaini545 – 628GP41InterPro annotationAdd BLAST84

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
Gene3Di2.170.40.20. 2 hits.
InterProiView protein in InterPro
IPR036377. Gp120_core_sf.
IPR000328. GP41-like.
IPR000777. HIV1_Gp120.
PfamiView protein in Pfam
PF00516. GP120. 2 hits.
PF00517. GP41. 1 hit.
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

K0GHK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKETQMNW PNLWKWGTLI LGLVIMCSAS DNLWVTVYYG VPVWRDADTT
60 70 80 90 100
LFCASDAKAH ETEVHNVWAT HACVPTDPNP QEMRLENVTE NFNMWKNNMV
110 120 130 140 150
EQMQEDVISL WDQSLQPCVK LTPLCVTLNC TEANFTKVNN DTDTIKLGNI
160 170 180 190 200
TDEVKNCSFN MTTEIIDKKQ KFYALFYKLD IIQIENGNDN NNNNTSREYR
210 220 230 240 250
LINCNTSAIK QACPKISFDP IPIHYCTPAG YALLKCNDKN FNGTGPCNNV
260 270 280 290 300
SSVQCTHGIK PVVSTQLLLN GSLAEDEIVI RSENLTDNAK TIIVHLNKSV
310 320 330 340 350
EINCTRPSNN TRKSIPIGPG RAFYQTGDII GDIRKAYCEI NATKWNETIN
360 370 380 390 400
QVTKKLKEHF NGSITFEPHS GGDLEITTHH FNCRGEFFYC NTSRLFNSTC
410 420 430 440 450
LKNHNTTSAS EECNDTITTD GNIILHCRIK QIINMWQGAG QAMYAPPISG
460 470 480 490 500
RINCVSNITG ILLTRDGGDT GKNETNGTRK EIFRPGGGNM KDNWRSELYK
510 520 530 540 550
YKVVQIEPLG IAPTRAKRRV VEREKRAVGI GAMIFGFLGA AGSTMGAASI
560 570 580 590 600
TLTVQARQLL SGIVQQQSNL LRAIEAQQHM LQLTVWGIKQ LQARVLAVER
610 620
YLKDQKFLGL WGCSGKIICT TAVPWNSS
Length:628
Mass (Da):70,311
Last modified:November 28, 2012 - v1
Checksum:i79A6DD1D01C20B83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX446702 Genomic RNA. Translation: AFU26020.1.

Similar proteinsi

Entry informationi

Entry nameiK0GHK5_9HIV1
AccessioniPrimary (citable) accession number: K0GHK5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 25, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)