ID   K0F8I8_NOCB7            Unreviewed;       418 AA.
AC   K0F8I8;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=alanine transaminase {ECO:0000256|ARBA:ARBA00026106};
DE            EC=2.6.1.2 {ECO:0000256|ARBA:ARBA00026106};
GN   ORFNames=O3I_040410 {ECO:0000313|EMBL:AFU06027.1};
OS   Nocardia brasiliensis (strain ATCC 700358 / HUJEG-1).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1133849 {ECO:0000313|EMBL:AFU06027.1, ECO:0000313|Proteomes:UP000006304};
RN   [1] {ECO:0000313|EMBL:AFU06027.1, ECO:0000313|Proteomes:UP000006304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700358 {ECO:0000313|Proteomes:UP000006304};
RX   PubMed=22535940; DOI=10.1128/JB.00210-12;
RA   Vera-Cabrera L., Ortiz-Lopez R., Elizondo-Gonzalez R., Perez-Maya A.A.,
RA   Ocampo-Candiani J.;
RT   "Complete genome sequence of Nocardia brasiliensis HUJEG-1.";
RL   J. Bacteriol. 194:2761-2762(2012).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00007441}.
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DR   EMBL; CP003876; AFU06027.1; -; Genomic_DNA.
DR   RefSeq; WP_014988874.1; NC_018681.1.
DR   AlphaFoldDB; K0F8I8; -.
DR   STRING; 1133849.O3I_040410; -.
DR   GeneID; 80365665; -.
DR   KEGG; nbr:O3I_040410; -.
DR   eggNOG; COG0436; Bacteria.
DR   HOGENOM; CLU_017584_4_2_11; -.
DR   Proteomes; UP000006304; Chromosome.
DR   GO; GO:0004021; F:L-alanine:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd00609; AAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR43488; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   PANTHER; PTHR43488:SF2; GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA; 1.
DR   Pfam; PF00155; Aminotran_1_2; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Aminotransferase {ECO:0000313|EMBL:AFU06027.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006304};
KW   Transferase {ECO:0000313|EMBL:AFU06027.1}.
FT   DOMAIN          48..395
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   418 AA;  46051 MW;  7990B12357F84CE5 CRC64;
     MGRVSPSHLP HRPPRVLEQS TKLQNVVYEI RGPVHAQAAR LEAEGHRILK LNIGNPAPFG
     FEAPDVIMRD IIASLPYAQG YSESKGITSA RRAVVTRYEL VPGFPELDVD DVYLGNGVSE
     LITITMQALL DNGDEVLIPA PDYPLWTAMT SLAGGTPVHY LCDESSGWQP DIADIESKIT
     DKTKALLVIN PNNPTGAVYS AEILQQLADI ARKHQLLLLA DEIYDKILYD DAKHVSMASV
     APDLLCLTFN GLSKAYRVAG YRSGWLAITG PKEHAAGFLE GIDLLASSRL CPNVPAQHAI
     QVALGGHQSI EDLILPGGRL LEQRDVAWER LNMIPGVSCV KPKGALYAFP RLDPNVYEIH
     DDSKLILDLL LQEKILMVQG TGFNWPNHDH LRIVTLPWAR DLAVAIERFG NFLSSYRQ
//