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K0F800

- K0F800_9NOCA

UniProt

K0F800 - K0F800_9NOCA

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Protein

Probable DNA ligase

Gene
ligB, lig, O3I_039425
Organism
Nocardia brasiliensis ATCC 700358
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei210 – 2101ATP By similarityUniRule annotation
Active sitei212 – 2121N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei217 – 2171ATP By similarityUniRule annotation
Binding sitei232 – 2321ATP By similarityUniRule annotation
Binding sitei261 – 2611ATP By similarityUniRule annotation
Binding sitei297 – 2971ATP By similarityUniRule annotation
Binding sitei368 – 3681ATP By similarityUniRule annotation
Binding sitei374 – 3741ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
ORF Names:O3I_039425Imported
OrganismiNocardia brasiliensis ATCC 700358Imported
Taxonomic identifieri1133849 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006304: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K0F800-1 [UniParc]FASTAAdd to Basket

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MLFSHVVQAS ETVRATRSRK TKIAAFAELL TAAAPDELAP VVAWVSGELR    50
QGRIGTGWRT LAGLDTPPAP VATLTVSAVD TALSEVAETS GTGSTARRKE 100
LLVALWTAAT AEEQAFLLRL LTGELRQGAL AAIVSEAVAV AAAVPVELVR 150
RAYMLSGRLP VTALAALTGG VAALREFRLE VGRPIQPMLA APGASLDEAL 200
TEFDGKVSAE IKMDGARIQV HRTGPRVWVF TRTLRDITAG VPELVDLVRG 250
LDCDSVVLDG ETLALDDSGR PRPFQETMSR FAEVSSTREL LLHPYFFDCL 300
HLDGQDLLDA PLSERRAALT KVAGEHSIPA LLEPDAEAAA EYFDGALAAG 350
HEGVMIKSLA APYAAGRRGR AWQKIKPTHT LDLLVLGAEW GYGRRTGYLS 400
NLHLGARDPL TGEPVMVGKT FKGLTDALLQ WQTAEFPRHE RTRDEHTVYL 450
YPELVVEIAL DGVQVSPRYP GGVALRFARV VRYRPDKEAR DADTIDTVRA 500
LLP 503
Length:503
Mass (Da):54,337
Last modified:November 28, 2012 - v1
Checksum:iC8B41995FFB5D5D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003876 Genomic DNA. Translation: AFU05832.1.
RefSeqiYP_006812806.1. NC_018681.1.

Genome annotation databases

EnsemblBacteriaiAFU05832; AFU05832; O3I_039425.
GeneIDi13731643.
KEGGinbr:O3I_039425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003876 Genomic DNA. Translation: AFU05832.1 .
RefSeqi YP_006812806.1. NC_018681.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFU05832 ; AFU05832 ; O3I_039425 .
GeneIDi 13731643.
KEGGi nbr:O3I_039425.

Phylogenomic databases

KOi K01971.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HUJEG-1Imported.

Entry informationi

Entry nameiK0F800_9NOCA
AccessioniPrimary (citable) accession number: K0F800
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: June 11, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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