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Protein

Probable DNA ligase

Gene

ligB

Organism
Nocardia brasiliensis ATCC 700358
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei210ATPUniRule annotation1
Active sitei212N6-AMP-lysine intermediateUniRule annotation1
Binding sitei217ATPUniRule annotation1
Binding sitei232ATPUniRule annotation1
Binding sitei261ATPUniRule annotation1
Binding sitei297ATPUniRule annotation1
Binding sitei368ATPUniRule annotation1
Binding sitei374ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciNBRA1133849:G1H3D-7951-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
ORF Names:O3I_039425Imported
OrganismiNocardia brasiliensis ATCC 700358Imported
Taxonomic identifieri1133849 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000006304 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 408DNA_LIGASE_A3InterPro annotationAdd BLAST124

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

K0F800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFSHVVQAS ETVRATRSRK TKIAAFAELL TAAAPDELAP VVAWVSGELR
60 70 80 90 100
QGRIGTGWRT LAGLDTPPAP VATLTVSAVD TALSEVAETS GTGSTARRKE
110 120 130 140 150
LLVALWTAAT AEEQAFLLRL LTGELRQGAL AAIVSEAVAV AAAVPVELVR
160 170 180 190 200
RAYMLSGRLP VTALAALTGG VAALREFRLE VGRPIQPMLA APGASLDEAL
210 220 230 240 250
TEFDGKVSAE IKMDGARIQV HRTGPRVWVF TRTLRDITAG VPELVDLVRG
260 270 280 290 300
LDCDSVVLDG ETLALDDSGR PRPFQETMSR FAEVSSTREL LLHPYFFDCL
310 320 330 340 350
HLDGQDLLDA PLSERRAALT KVAGEHSIPA LLEPDAEAAA EYFDGALAAG
360 370 380 390 400
HEGVMIKSLA APYAAGRRGR AWQKIKPTHT LDLLVLGAEW GYGRRTGYLS
410 420 430 440 450
NLHLGARDPL TGEPVMVGKT FKGLTDALLQ WQTAEFPRHE RTRDEHTVYL
460 470 480 490 500
YPELVVEIAL DGVQVSPRYP GGVALRFARV VRYRPDKEAR DADTIDTVRA

LLP
Length:503
Mass (Da):54,337
Last modified:November 28, 2012 - v1
Checksum:iC8B41995FFB5D5D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003876 Genomic DNA Translation: AFU05832.1
RefSeqiWP_014988679.1, NC_018681.1

Genome annotation databases

EnsemblBacteriaiAFU05832; AFU05832; O3I_039425
KEGGinbr:O3I_039425

Similar proteinsi

Entry informationi

Entry nameiK0F800_9NOCA
AccessioniPrimary (citable) accession number: K0F800
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: March 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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