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K0F800

- K0F800_9NOCA

UniProt

K0F800 - K0F800_9NOCA

Protein

Probable DNA ligase

Gene

ligB

Organism
Nocardia brasiliensis ATCC 700358
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei210 – 2101ATPUniRule annotation
    Active sitei212 – 2121N6-AMP-lysine intermediateUniRule annotation
    Binding sitei217 – 2171ATPUniRule annotation
    Binding sitei232 – 2321ATPUniRule annotation
    Binding sitei261 – 2611ATPUniRule annotation
    Binding sitei297 – 2971ATPUniRule annotation
    Binding sitei368 – 3681ATPUniRule annotation
    Binding sitei374 – 3741ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligBImported
    Synonyms:ligUniRule annotation
    ORF Names:O3I_039425Imported
    OrganismiNocardia brasiliensis ATCC 700358Imported
    Taxonomic identifieri1133849 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006304: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK01971.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    K0F800-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFSHVVQAS ETVRATRSRK TKIAAFAELL TAAAPDELAP VVAWVSGELR    50
    QGRIGTGWRT LAGLDTPPAP VATLTVSAVD TALSEVAETS GTGSTARRKE 100
    LLVALWTAAT AEEQAFLLRL LTGELRQGAL AAIVSEAVAV AAAVPVELVR 150
    RAYMLSGRLP VTALAALTGG VAALREFRLE VGRPIQPMLA APGASLDEAL 200
    TEFDGKVSAE IKMDGARIQV HRTGPRVWVF TRTLRDITAG VPELVDLVRG 250
    LDCDSVVLDG ETLALDDSGR PRPFQETMSR FAEVSSTREL LLHPYFFDCL 300
    HLDGQDLLDA PLSERRAALT KVAGEHSIPA LLEPDAEAAA EYFDGALAAG 350
    HEGVMIKSLA APYAAGRRGR AWQKIKPTHT LDLLVLGAEW GYGRRTGYLS 400
    NLHLGARDPL TGEPVMVGKT FKGLTDALLQ WQTAEFPRHE RTRDEHTVYL 450
    YPELVVEIAL DGVQVSPRYP GGVALRFARV VRYRPDKEAR DADTIDTVRA 500
    LLP 503
    Length:503
    Mass (Da):54,337
    Last modified:November 28, 2012 - v1
    Checksum:iC8B41995FFB5D5D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003876 Genomic DNA. Translation: AFU05832.1.
    RefSeqiYP_006812806.1. NC_018681.1.

    Genome annotation databases

    EnsemblBacteriaiAFU05832; AFU05832; O3I_039425.
    GeneIDi13731643.
    KEGGinbr:O3I_039425.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003876 Genomic DNA. Translation: AFU05832.1 .
    RefSeqi YP_006812806.1. NC_018681.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFU05832 ; AFU05832 ; O3I_039425 .
    GeneIDi 13731643.
    KEGGi nbr:O3I_039425.

    Phylogenomic databases

    KOi K01971.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HUJEG-1Imported.

    Entry informationi

    Entry nameiK0F800_9NOCA
    AccessioniPrimary (citable) accession number: K0F800
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3