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K0ETK7

- K0ETK7_9NOCA

UniProt

K0ETK7 - K0ETK7_9NOCA

Protein

Isocitrate dehydrogenase [NADP]

Gene

O3I_005215

Organism
Nocardia brasiliensis ATCC 700358
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 11 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771Substrate
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321Substrate
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei212 – 2121Critical for catalysisUniRule annotation
    Metal bindingi252 – 2521Magnesium or manganeseUniRule annotation
    Binding sitei260 – 2601NADPUniRule annotation
    Metal bindingi275 – 2751Magnesium or manganeseUniRule annotation
    Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi310 – 3156NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:O3I_005215Imported
    OrganismiNocardia brasiliensis ATCC 700358Imported
    Taxonomic identifieri1133849 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006304: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    K0ETK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKIKVEGTV VELDGDEMTR IIWQFIKDKL IHPYLDVNLE YYDLGIEYRD    50
    KTDDQVTIDA AEAIKRHGVG VKCATITPDE ARVKEFGLKK MWRSPNGTIR 100
    NILGGTIFRA PIIISNVPRL VPGWTKPIII GRHAFGDQYR ATDFKVYQAG 150
    TVTVTFTPED GSEPIQHEVV KMPEDGGVVM GMYNFKNSII DFARASFNYG 200
    LQQNYPVYLS TKNTILKAYD GMFKDTFQDV FDAEFKTQFD AAGLTYEHRL 250
    IDDMVASSMK WEGGYVWACK NYDGDVQSDT VAQGFGSLGL MTSVLLTPDG 300
    KTCEAEAAHG TVTRHYRQHQ QGKPTSTNPI ASIFAWTRGL EHRGKLDNTP 350
    EVIGFSQTLE DVVIKTVEGG QMTKDLALLV GGDQGYLSTE EFLGALDANL 400
    ARALR 405
    Length:405
    Mass (Da):45,139
    Last modified:November 28, 2012 - v1
    Checksum:iC88C1A6810E2F50B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003876 Genomic DNA. Translation: AFT99005.1.
    RefSeqiWP_014981861.1. NC_018681.1.
    YP_006805980.1. NC_018681.1.

    Genome annotation databases

    EnsemblBacteriaiAFT99005; AFT99005; O3I_005215.
    GeneIDi13727059.
    KEGGinbr:O3I_005215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003876 Genomic DNA. Translation: AFT99005.1 .
    RefSeqi WP_014981861.1. NC_018681.1.
    YP_006805980.1. NC_018681.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFT99005 ; AFT99005 ; O3I_005215 .
    GeneIDi 13727059.
    KEGGi nbr:O3I_005215.

    Phylogenomic databases

    KOi K00031.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HUJEG-1Imported.

    Entry informationi

    Entry nameiK0ETK7_9NOCA
    AccessioniPrimary (citable) accession number: K0ETK7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 11 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3