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K0ETK7 (K0ETK7_9NOCA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
ORF Names:O3I_005215 EMBL AFT99005.1
OrganismNocardia brasiliensis ATCC 700358 [Complete proteome] EMBL AFT99005.1
Taxonomic identifier1133849 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding310 – 3156NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2521Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2751Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2601NADP By similarity PIRSR PIRSR000108-4
Binding site3281NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2121Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
K0ETK7 [UniParc].

Last modified November 28, 2012. Version 1.
Checksum: C88C1A6810E2F50B

FASTA40545,139
        10         20         30         40         50         60 
MSKIKVEGTV VELDGDEMTR IIWQFIKDKL IHPYLDVNLE YYDLGIEYRD KTDDQVTIDA 

        70         80         90        100        110        120 
AEAIKRHGVG VKCATITPDE ARVKEFGLKK MWRSPNGTIR NILGGTIFRA PIIISNVPRL 

       130        140        150        160        170        180 
VPGWTKPIII GRHAFGDQYR ATDFKVYQAG TVTVTFTPED GSEPIQHEVV KMPEDGGVVM 

       190        200        210        220        230        240 
GMYNFKNSII DFARASFNYG LQQNYPVYLS TKNTILKAYD GMFKDTFQDV FDAEFKTQFD 

       250        260        270        280        290        300 
AAGLTYEHRL IDDMVASSMK WEGGYVWACK NYDGDVQSDT VAQGFGSLGL MTSVLLTPDG 

       310        320        330        340        350        360 
KTCEAEAAHG TVTRHYRQHQ QGKPTSTNPI ASIFAWTRGL EHRGKLDNTP EVIGFSQTLE 

       370        380        390        400 
DVVIKTVEGG QMTKDLALLV GGDQGYLSTE EFLGALDANL ARALR 

« Hide

References

[1]"Complete genome sequence of Nocardia brasiliensis HUJEG-1."
Vera-Cabrera L., Ortiz-Lopez R., Elizondo-Gonzalez R., Perez-Maya A.A., Ocampo-Candiani J.
J. Bacteriol. 194:2761-2762(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HUJEG-1 EMBL AFT99005.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003876 Genomic DNA. Translation: AFT99005.1.
RefSeqYP_006805980.1. NC_018681.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFT99005; AFT99005; O3I_005215.
GeneID13727059.
KEGGnbr:O3I_005215.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK0ETK7_9NOCA
AccessionPrimary (citable) accession number: K0ETK7
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: July 9, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)