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K0ETK7

- K0ETK7_9NOCA

UniProt

K0ETK7 - K0ETK7_9NOCA

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Protein
Isocitrate dehydrogenase [NADP]
Gene
O3I_005215
Organism
Nocardia brasiliensis ATCC 700358
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei212 – 2121Critical for catalysis By similarityUniRule annotation
Metal bindingi252 – 2521Magnesium or manganese By similarityUniRule annotation
Binding sitei260 – 2601NADP By similarityUniRule annotation
Metal bindingi275 – 2751Magnesium or manganese By similarityUniRule annotation
Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi310 – 3156NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:O3I_005215Imported
OrganismiNocardia brasiliensis ATCC 700358Imported
Taxonomic identifieri1133849 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006304: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K0ETK7-1 [UniParc]FASTAAdd to Basket

« Hide

MSKIKVEGTV VELDGDEMTR IIWQFIKDKL IHPYLDVNLE YYDLGIEYRD    50
KTDDQVTIDA AEAIKRHGVG VKCATITPDE ARVKEFGLKK MWRSPNGTIR 100
NILGGTIFRA PIIISNVPRL VPGWTKPIII GRHAFGDQYR ATDFKVYQAG 150
TVTVTFTPED GSEPIQHEVV KMPEDGGVVM GMYNFKNSII DFARASFNYG 200
LQQNYPVYLS TKNTILKAYD GMFKDTFQDV FDAEFKTQFD AAGLTYEHRL 250
IDDMVASSMK WEGGYVWACK NYDGDVQSDT VAQGFGSLGL MTSVLLTPDG 300
KTCEAEAAHG TVTRHYRQHQ QGKPTSTNPI ASIFAWTRGL EHRGKLDNTP 350
EVIGFSQTLE DVVIKTVEGG QMTKDLALLV GGDQGYLSTE EFLGALDANL 400
ARALR 405
Length:405
Mass (Da):45,139
Last modified:November 28, 2012 - v1
Checksum:iC88C1A6810E2F50B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003876 Genomic DNA. Translation: AFT99005.1.
RefSeqiWP_014981861.1. NC_018681.1.
YP_006805980.1. NC_018681.1.

Genome annotation databases

EnsemblBacteriaiAFT99005; AFT99005; O3I_005215.
GeneIDi13727059.
KEGGinbr:O3I_005215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003876 Genomic DNA. Translation: AFT99005.1 .
RefSeqi WP_014981861.1. NC_018681.1.
YP_006805980.1. NC_018681.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFT99005 ; AFT99005 ; O3I_005215 .
GeneIDi 13727059.
KEGGi nbr:O3I_005215.

Phylogenomic databases

KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HUJEG-1Imported.

Entry informationi

Entry nameiK0ETK7_9NOCA
AccessioniPrimary (citable) accession number: K0ETK7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 3, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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