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K0EEW4

- K0EEW4_ALTMB

UniProt

K0EEW4 - K0EEW4_ALTMB

Protein

Kynureninase

Gene

AMBAS45_08240

Organism
Alteromonas macleodii (strain Balearic Sea AD45)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 7 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    2. NAD biosynthetic process Source: UniProtKB-UniPathway
    3. tryptophan catabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Gene namesi
    Ordered Locus Names:AMBAS45_08240Imported
    OrganismiAlteromonas macleodii (strain Balearic Sea AD45)Imported
    Taxonomic identifieri1004787 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
    ProteomesiUP000006308: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    K0EEW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMNKVFSAEQ LDIKDPLRDK AQAFSLPANT VYLDGNSLGP LPRAAKQRAD    50
    EVVSEQWGKG LITSWNKHQW IHLPQIVGDK IGGLIGAKSG QVICCDSISI 100
    NLFKVLSAAL KMQPTRKVIA TTRDNFPTDI YMVQGLLDLL GSDYSIRYVD 150
    EASIGSQLTD DIAVLMLTQV NFRSGNKLDM QTITEQAHQK GILTLWDLAH 200
    SAGAFPVSLD ACNVDFAVGC TYKYLNGGPG APAFIYVAKR HQAQYQQPLS 250
    GWMGHSSPFS FSPDYAGDNS VKQNLCGTPG IIGMSILDAA LDVFEDVSLK 300
    AIDEKSKKLQ AFFIAEAKRA GLLDKFSIVS PSIDDRGSQL AFAHDQAYAI 350
    CQAWIAEGVI ADFRAPNILR IGFAPLYLSF VDIEKAVASL TEIMIEKRYE 400
    NDEFQQRQSV T 411
    Length:411
    Mass (Da):45,111
    Last modified:November 28, 2012 - v1
    Checksum:i077321076D061560
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003873 Genomic DNA. Translation: AFT95123.1.
    RefSeqiYP_006802604.1. NC_018679.1.

    Genome annotation databases

    EnsemblBacteriaiAFT95123; AFT95123; AMBAS45_08240.
    GeneIDi13744176.
    KEGGiamb:AMBAS45_08240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003873 Genomic DNA. Translation: AFT95123.1 .
    RefSeqi YP_006802604.1. NC_018679.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFT95123 ; AFT95123 ; AMBAS45_08240 .
    GeneIDi 13744176.
    KEGGi amb:AMBAS45_08240.

    Phylogenomic databases

    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomes of surface isolates of Alteromonas macleodii: the life of a widespread marine opportunistic copiotroph."
      Lopez-Perez M., Gonzaga A., Martin-Cuadrado A.B., Onyshchenko O., Ghavidel A., Ghai R., Rodriguez-Valera F.
      Sci. Rep. 2:696-696(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Balearic Sea AD45Imported.

    Entry informationi

    Entry nameiK0EEW4_ALTMB
    AccessioniPrimary (citable) accession number: K0EEW4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 7 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3