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K0DKS5

- K0DKS5_9BURK

UniProt

K0DKS5 - K0DKS5_9BURK

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Protein

Kynureninase

Gene
BUPH_01854
Organism
Burkholderia phenoliruptrix BR3459a
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  2. NAD biosynthetic process Source: UniProtKB-UniPathway
  3. tryptophan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Gene namesi
ORF Names:BUPH_01854Imported
OrganismiBurkholderia phenoliruptrix BR3459aImported
Taxonomic identifieri1229205 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000010105: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

K0DKS5-1 [UniParc]FASTAAdd to Basket

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MTDITVPALA AEDAFALTRE KFALPEGVRY FDGNSLGPLP KAVQMQAYIT    50
TTHEWGDGLI RSWQDARWNT LPQRVGDAIG RLVGASEGQV VACDSTSVNL 100
FKALTAAVRL RPDRKVIVTD ASSFPTDLYI TEQVAALTGT AVLSVPASEI 150
PAALNGNVAA VVLCHVDYRS AEVYDLAGLT QAAHEAGALM VCDLSHSAGA 200
MPCNLDQTEV DFAVGCGYKY LNGGPGAPAF LYAAKRHHAD AQQPLTGWFG 250
HAAPFDFTQK YAPAPGIERF LCGTNQVIAL SLLSRALEVF NGISIEEIRT 300
RSLELTGQFI ASSEARLAEH GFVIASPKEP EVRGSHVSLR HPQGYAIMQE 350
LGRRGVIGDF RMPDFMRFGF APLFNTADEV EYLVDQINEI MKTGAWNNPA 400
YERRRAFT 408
Length:408
Mass (Da):44,266
Last modified:November 28, 2012 - v1
Checksum:i847A18303E23766C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003863 Genomic DNA. Translation: AFT85425.1.
RefSeqiWP_015002344.1. NC_018695.1.
YP_006833607.1. NC_018695.1.

Genome annotation databases

EnsemblBacteriaiAFT85425; AFT85425; BUPH_01854.
GeneIDi13768319.
KEGGibpx:BUPH_01854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003863 Genomic DNA. Translation: AFT85425.1 .
RefSeqi WP_015002344.1. NC_018695.1.
YP_006833607.1. NC_018695.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFT85425 ; AFT85425 ; BUPH_01854 .
GeneIDi 13768319.
KEGGi bpx:BUPH_01854.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BR3459aImported.

Entry informationi

Entry nameiK0DKS5_9BURK
AccessioniPrimary (citable) accession number: K0DKS5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 3, 2014
This is version 8 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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