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K0DKS5 (K0DKS5_9BURK) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 5. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800
Gene names
ORF Names:BUPH_01854 EMBL AFT85425.1
OrganismBurkholderia phenoliruptrix BR3459a EMBL AFT85425.1
Taxonomic identifier1229205 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia ›

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
K0DKS5 [UniParc].

Last modified November 28, 2012. Version 1.
Checksum: 847A18303E23766C

FASTA40844,266
        10         20         30         40         50         60 
MTDITVPALA AEDAFALTRE KFALPEGVRY FDGNSLGPLP KAVQMQAYIT TTHEWGDGLI 

        70         80         90        100        110        120 
RSWQDARWNT LPQRVGDAIG RLVGASEGQV VACDSTSVNL FKALTAAVRL RPDRKVIVTD 

       130        140        150        160        170        180 
ASSFPTDLYI TEQVAALTGT AVLSVPASEI PAALNGNVAA VVLCHVDYRS AEVYDLAGLT 

       190        200        210        220        230        240 
QAAHEAGALM VCDLSHSAGA MPCNLDQTEV DFAVGCGYKY LNGGPGAPAF LYAAKRHHAD 

       250        260        270        280        290        300 
AQQPLTGWFG HAAPFDFTQK YAPAPGIERF LCGTNQVIAL SLLSRALEVF NGISIEEIRT 

       310        320        330        340        350        360 
RSLELTGQFI ASSEARLAEH GFVIASPKEP EVRGSHVSLR HPQGYAIMQE LGRRGVIGDF 

       370        380        390        400 
RMPDFMRFGF APLFNTADEV EYLVDQINEI MKTGAWNNPA YERRRAFT

« Hide

References

[1]"Complete Genome Sequence of Burkholderia phenoliruptrix BR3459a (CLA1), a Heat-Tolerant, Nitrogen-Fixing Symbiont of Mimosa flocculosa."
de Oliveira Cunha C., Goda Zuleta L.F., Paula de Almeida L.G., Prioli Ciapina L., Lustrino Borges W., Pitard R.M., Baldani J.I., Straliotto R., de Faria S.M., Hungria M., Sousa Cavada B., Mercante F.M., Ribeiro de Vasconcelos A.T.
J. Bacteriol. 194:6675-6676(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BR3459a EMBL AFT85425.1.
[2]Cunha C.O., Zuleta L.F.G., Almeida L.G.P., Ciapina L.P., Borges W.L., Pitard R.M., Baldani J.I., Rosangela S.R., Faria S.M., Hungria M., Cavada B.S., Mercante F.M., Vasconcelos A.T.R.
Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BR3459a EMBL AFT85425.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003863 Genomic DNA. Translation: AFT85425.1.
RefSeqYP_006833607.1. NC_018695.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFT85425; AFT85425; BUPH_01854.
GeneID13768319.
KEGGbpx:BUPH_01854.

Phylogenomic databases

KOK01556.

Enzyme and pathway databases

UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameK0DKS5_9BURK
AccessionPrimary (citable) accession number: K0DKS5
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: April 3, 2013
This is version 5 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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