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K0DKS5

- K0DKS5_9BURK

UniProt

K0DKS5 - K0DKS5_9BURK

Protein

Kynureninase

Gene

BUPH_01854

Organism
Burkholderia phenoliruptrix BR3459a
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 9 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    2. NAD biosynthetic process Source: UniProtKB-UniPathway
    3. tryptophan catabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Gene namesi
    ORF Names:BUPH_01854Imported
    OrganismiBurkholderia phenoliruptrix BR3459aImported
    Taxonomic identifieri1229205 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000010105: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    K0DKS5-1 [UniParc]FASTAAdd to Basket

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    MTDITVPALA AEDAFALTRE KFALPEGVRY FDGNSLGPLP KAVQMQAYIT    50
    TTHEWGDGLI RSWQDARWNT LPQRVGDAIG RLVGASEGQV VACDSTSVNL 100
    FKALTAAVRL RPDRKVIVTD ASSFPTDLYI TEQVAALTGT AVLSVPASEI 150
    PAALNGNVAA VVLCHVDYRS AEVYDLAGLT QAAHEAGALM VCDLSHSAGA 200
    MPCNLDQTEV DFAVGCGYKY LNGGPGAPAF LYAAKRHHAD AQQPLTGWFG 250
    HAAPFDFTQK YAPAPGIERF LCGTNQVIAL SLLSRALEVF NGISIEEIRT 300
    RSLELTGQFI ASSEARLAEH GFVIASPKEP EVRGSHVSLR HPQGYAIMQE 350
    LGRRGVIGDF RMPDFMRFGF APLFNTADEV EYLVDQINEI MKTGAWNNPA 400
    YERRRAFT 408
    Length:408
    Mass (Da):44,266
    Last modified:November 28, 2012 - v1
    Checksum:i847A18303E23766C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003863 Genomic DNA. Translation: AFT85425.1.
    RefSeqiWP_015002344.1. NC_018695.1.
    YP_006833607.1. NC_018695.1.

    Genome annotation databases

    EnsemblBacteriaiAFT85425; AFT85425; BUPH_01854.
    GeneIDi13768319.
    KEGGibpx:BUPH_01854.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003863 Genomic DNA. Translation: AFT85425.1 .
    RefSeqi WP_015002344.1. NC_018695.1.
    YP_006833607.1. NC_018695.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFT85425 ; AFT85425 ; BUPH_01854 .
    GeneIDi 13768319.
    KEGGi bpx:BUPH_01854.

    Phylogenomic databases

    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BR3459aImported.

    Entry informationi

    Entry nameiK0DKS5_9BURK
    AccessioniPrimary (citable) accession number: K0DKS5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 9 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3