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Protein

Alanine racemase

Gene

BgCN_0158

Organism
Borrelia garinii NMJW1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Active sitei262 – 2621Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:BgCN_0158Imported
OrganismiBorrelia garinii NMJW1Imported
Taxonomic identifieri1234596 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000006300: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliK0DFN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K0DFN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNKTIIIN LNNLEHNLNL IKNKIGEKEI VATLKGDAYG HGLINIFKFF
60 70 80 90 100
KEKKINYFGL SNIEDAKTLK KIDKNIKILM YIKVDKKEIK NLIKLELLPF
110 120 130 140 150
VADFEYLFLI EKECALQKKK IKVHLKIDIG MNRYGIRIDS ALEIATYIQN
160 170 180 190 200
SQFLELEGIC SHLPATENFK ITQKQIEQFL LVLETLKQKN INPKFVHISN
210 220 230 240 250
SGHIINYKLN PQFNMVRPGL ILYGYCQSIK NKKTTLNFKP VLNLFSKVIF
260 270 280 290 300
IKNVKKGEKI SYSGIFQAKE DMKIGIIPIG YFDGIPQNIN NNFYFLINNQ
310 320 330 340 350
KCKIRGKVCM NLTIVEIPKD LKVRTGSKVE IVSEKLSIDK MSKFSKRSHY
360
ELLCNIGKYE KRKYLD
Length:366
Mass (Da):42,425
Last modified:November 28, 2012 - v1
Checksum:i349EEFEAD8398E8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003866 Genomic DNA. Translation: AFT83493.1.
RefSeqiWP_015026670.1. NC_018747.1.
YP_006870859.1. NC_018747.1.

Genome annotation databases

EnsemblBacteriaiAFT83493; AFT83493; BgCN_0158.
GeneIDi13812369.
KEGGibgn:BgCN_0158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003866 Genomic DNA. Translation: AFT83493.1.
RefSeqiWP_015026670.1. NC_018747.1.
YP_006870859.1. NC_018747.1.

3D structure databases

ProteinModelPortaliK0DFN1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFT83493; AFT83493; BgCN_0158.
GeneIDi13812369.
KEGGibgn:BgCN_0158.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome Sequence of Borrelia garinii Strain NMJW1, Isolated from China."
    Jiang B., Yao H., Tong Y., Yang X., Huang Y., Jiang J., Cao W.
    J. Bacteriol. 194:6660-6661(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NMJW1Imported.

Entry informationi

Entry nameiK0DFN1_BORGR
AccessioniPrimary (citable) accession number: K0DFN1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: March 4, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.