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K0CPG2

- K0CPG2_ALTME

UniProt

K0CPG2 - K0CPG2_ALTME

Protein

Kynureninase

Gene

AMEC673_07705

Organism
Alteromonas macleodii (strain English Channel 673)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 9 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    2. NAD biosynthetic process Source: UniProtKB-UniPathway
    3. tryptophan catabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Gene namesi
    Ordered Locus Names:AMEC673_07705Imported
    OrganismiAlteromonas macleodii (strain English Channel 673)Imported
    Taxonomic identifieri1004788 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
    ProteomesiUP000006296: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.
    OMAiHVAYRSA.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    K0CPG2-1 [UniParc]FASTAAdd to Basket

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    MMNKVFSAEQ LDIKDPLRDK AQAFSLPANT VYLDGNSLGP LPKAAKQRAD    50
    EVVNEQWGKG LITSWNKHQW IHLPQIVGDK IGGLIGAKSG QVICCDSISI 100
    NLFKVLSAAL KMHPSRKVIA TTRDNFPTDI YMVQGLLDLL GSDYSIRYVD 150
    EACIGSQLTD DIAVLMLTQV NFRSGNKLDM QTITEQAHQK GILTLWDLAH 200
    SAGAFPVSLD ACNVDFAVGC TYKYLNGGPG APAFIYVAKR HQAQYQQPLS 250
    GWMGHSSPFS FSPDYAGDNS VKQNLCGTPG IIGMSILDAA LDVFEDVSLK 300
    AIDEKSKKLQ AFFIAEAKRA GLLDKFSIVS PNIDNRGSQL AFAHDHAYAI 350
    CQAWIAEGVI ADFRAPNILR IGFAPLYLSF VDIEKAMASL TEIMNEKRYE 400
    NDEFQQRQSV T 411
    Length:411
    Mass (Da):45,189
    Last modified:November 28, 2012 - v1
    Checksum:iE6DB18EB9726BFF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003844 Genomic DNA. Translation: AFT74235.1.
    RefSeqiWP_014976274.1. NC_018678.1.
    YP_006798612.1. NC_018678.1.

    Genome annotation databases

    EnsemblBacteriaiAFT74235; AFT74235; AMEC673_07705.
    GeneIDi13743259.
    KEGGiamg:AMEC673_07705.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003844 Genomic DNA. Translation: AFT74235.1 .
    RefSeqi WP_014976274.1. NC_018678.1.
    YP_006798612.1. NC_018678.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFT74235 ; AFT74235 ; AMEC673_07705 .
    GeneIDi 13743259.
    KEGGi amg:AMEC673_07705.

    Phylogenomic databases

    KOi K01556.
    OMAi HVAYRSA.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomes of surface isolates of Alteromonas macleodii: the life of a widespread marine opportunistic copiotroph."
      Lopez-Perez M., Gonzaga A., Martin-Cuadrado A.B., Onyshchenko O., Ghavidel A., Ghai R., Rodriguez-Valera F.
      Sci. Rep. 2:696-696(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: English Channel 673Imported.

    Entry informationi

    Entry nameiK0CPG2_ALTME
    AccessioniPrimary (citable) accession number: K0CPG2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 9 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3