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K0CPG2 (K0CPG2_ALTME) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 6. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
K0CPG2 [UniParc].

Last modified November 28, 2012. Version 1.
Checksum: E6DB18EB9726BFF5

FASTA41145,189
        10         20         30         40         50         60 
MMNKVFSAEQ LDIKDPLRDK AQAFSLPANT VYLDGNSLGP LPKAAKQRAD EVVNEQWGKG 

        70         80         90        100        110        120 
LITSWNKHQW IHLPQIVGDK IGGLIGAKSG QVICCDSISI NLFKVLSAAL KMHPSRKVIA 

       130        140        150        160        170        180 
TTRDNFPTDI YMVQGLLDLL GSDYSIRYVD EACIGSQLTD DIAVLMLTQV NFRSGNKLDM 

       190        200        210        220        230        240 
QTITEQAHQK GILTLWDLAH SAGAFPVSLD ACNVDFAVGC TYKYLNGGPG APAFIYVAKR 

       250        260        270        280        290        300 
HQAQYQQPLS GWMGHSSPFS FSPDYAGDNS VKQNLCGTPG IIGMSILDAA LDVFEDVSLK 

       310        320        330        340        350        360 
AIDEKSKKLQ AFFIAEAKRA GLLDKFSIVS PNIDNRGSQL AFAHDHAYAI CQAWIAEGVI 

       370        380        390        400        410 
ADFRAPNILR IGFAPLYLSF VDIEKAMASL TEIMNEKRYE NDEFQQRQSV T 

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References

[1]"Genomes of surface isolates of Alteromonas macleodii: the life of a widespread marine opportunistic copiotroph."
Lopez-Perez M., Gonzaga A., Martin-Cuadrado A.B., Onyshchenko O., Ghavidel A., Ghai R., Rodriguez-Valera F.
Sci. Rep. 2:696-696(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: English Channel 673.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003844 Genomic DNA. Translation: AFT74235.1.
RefSeqYP_006798612.1. NC_018678.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFT74235; AFT74235; AMEC673_07705.
GeneID13743259.
KEGGamg:AMEC673_07705.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01556.

Enzyme and pathway databases

UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameK0CPG2_ALTME
AccessionPrimary (citable) accession number: K0CPG2
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 16, 2013
This is version 6 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)