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Protein

Kynureninase

Gene

AMEC673_07705

Organism
Alteromonas macleodii (strain English Channel 673)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  2. NAD biosynthetic process Source: UniProtKB-UniPathway
  3. tryptophan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Gene namesi
Ordered Locus Names:AMEC673_07705Imported
OrganismiAlteromonas macleodii (strain English Channel 673)Imported
Taxonomic identifieri1004788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000006296: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556.
OMAiRFWQPLS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

K0CPG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNKVFSAEQ LDIKDPLRDK AQAFSLPANT VYLDGNSLGP LPKAAKQRAD
60 70 80 90 100
EVVNEQWGKG LITSWNKHQW IHLPQIVGDK IGGLIGAKSG QVICCDSISI
110 120 130 140 150
NLFKVLSAAL KMHPSRKVIA TTRDNFPTDI YMVQGLLDLL GSDYSIRYVD
160 170 180 190 200
EACIGSQLTD DIAVLMLTQV NFRSGNKLDM QTITEQAHQK GILTLWDLAH
210 220 230 240 250
SAGAFPVSLD ACNVDFAVGC TYKYLNGGPG APAFIYVAKR HQAQYQQPLS
260 270 280 290 300
GWMGHSSPFS FSPDYAGDNS VKQNLCGTPG IIGMSILDAA LDVFEDVSLK
310 320 330 340 350
AIDEKSKKLQ AFFIAEAKRA GLLDKFSIVS PNIDNRGSQL AFAHDHAYAI
360 370 380 390 400
CQAWIAEGVI ADFRAPNILR IGFAPLYLSF VDIEKAMASL TEIMNEKRYE
410
NDEFQQRQSV T
Length:411
Mass (Da):45,189
Last modified:November 28, 2012 - v1
Checksum:iE6DB18EB9726BFF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003844 Genomic DNA. Translation: AFT74235.1.
RefSeqiYP_006798612.1. NC_018678.1.

Genome annotation databases

EnsemblBacteriaiAFT74235; AFT74235; AMEC673_07705.
GeneIDi13743259.
KEGGiamg:AMEC673_07705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003844 Genomic DNA. Translation: AFT74235.1.
RefSeqiYP_006798612.1. NC_018678.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFT74235; AFT74235; AMEC673_07705.
GeneIDi13743259.
KEGGiamg:AMEC673_07705.

Phylogenomic databases

KOiK01556.
OMAiRFWQPLS.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genomes of surface isolates of Alteromonas macleodii: the life of a widespread marine opportunistic copiotroph."
    Lopez-Perez M., Gonzaga A., Martin-Cuadrado A.B., Onyshchenko O., Ghavidel A., Ghai R., Rodriguez-Valera F.
    Sci. Rep. 2:696-696(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: English Channel 673Imported.

Entry informationi

Entry nameiK0CPG2_ALTME
AccessioniPrimary (citable) accession number: K0CPG2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: February 4, 2015
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.