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K0CPG2

- K0CPG2_ALTME

UniProt

K0CPG2 - K0CPG2_ALTME

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Protein
Kynureninase
Gene
AMEC673_07705
Organism
Alteromonas macleodii (strain English Channel 673)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  2. NAD biosynthetic process Source: UniProtKB-UniPathway
  3. tryptophan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Gene namesi
Ordered Locus Names:AMEC673_07705Imported
OrganismiAlteromonas macleodii (strain English Channel 673)Imported
Taxonomic identifieri1004788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000006296: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556.
OMAiHVAYRSA.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

K0CPG2-1 [UniParc]FASTAAdd to Basket

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MMNKVFSAEQ LDIKDPLRDK AQAFSLPANT VYLDGNSLGP LPKAAKQRAD    50
EVVNEQWGKG LITSWNKHQW IHLPQIVGDK IGGLIGAKSG QVICCDSISI 100
NLFKVLSAAL KMHPSRKVIA TTRDNFPTDI YMVQGLLDLL GSDYSIRYVD 150
EACIGSQLTD DIAVLMLTQV NFRSGNKLDM QTITEQAHQK GILTLWDLAH 200
SAGAFPVSLD ACNVDFAVGC TYKYLNGGPG APAFIYVAKR HQAQYQQPLS 250
GWMGHSSPFS FSPDYAGDNS VKQNLCGTPG IIGMSILDAA LDVFEDVSLK 300
AIDEKSKKLQ AFFIAEAKRA GLLDKFSIVS PNIDNRGSQL AFAHDHAYAI 350
CQAWIAEGVI ADFRAPNILR IGFAPLYLSF VDIEKAMASL TEIMNEKRYE 400
NDEFQQRQSV T 411
Length:411
Mass (Da):45,189
Last modified:November 28, 2012 - v1
Checksum:iE6DB18EB9726BFF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003844 Genomic DNA. Translation: AFT74235.1.
RefSeqiWP_014976274.1. NC_018678.1.
YP_006798612.1. NC_018678.1.

Genome annotation databases

EnsemblBacteriaiAFT74235; AFT74235; AMEC673_07705.
GeneIDi13743259.
KEGGiamg:AMEC673_07705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003844 Genomic DNA. Translation: AFT74235.1 .
RefSeqi WP_014976274.1. NC_018678.1.
YP_006798612.1. NC_018678.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFT74235 ; AFT74235 ; AMEC673_07705 .
GeneIDi 13743259.
KEGGi amg:AMEC673_07705.

Phylogenomic databases

KOi K01556.
OMAi HVAYRSA.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomes of surface isolates of Alteromonas macleodii: the life of a widespread marine opportunistic copiotroph."
    Lopez-Perez M., Gonzaga A., Martin-Cuadrado A.B., Onyshchenko O., Ghavidel A., Ghai R., Rodriguez-Valera F.
    Sci. Rep. 2:696-696(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: English Channel 673.

Entry informationi

Entry nameiK0CPG2_ALTME
AccessioniPrimary (citable) accession number: K0CPG2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 3, 2014
This is version 8 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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