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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

Q91_1570

Organism
Cycloclasticus sp. (strain P1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Ordered Locus Names:Q91_1570Imported
OrganismiCycloclasticus sp. (strain P1)Imported
Taxonomic identifieri385025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeCycloclasticus
ProteomesiUP000006282 Componenti: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.
OMAiNSGQMWG.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

K0C4Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKKSKIIY TLTDEAPLLA TASFLPIVEA FAGAAGIDVE VSDISLASRV
60 70 80 90 100
LATFADQLPD DQKVPDALSE LGRLTQNPET NIIKLPNISA SVPQLKAIIN
110 120 130 140 150
ELQGKGFDIP NYPEDPQTDE EKALQQKYGK VLGSAVNPVL REGNSDRRAP
160 170 180 190 200
KAVKEYAKKN PHSMGKWSQA SRTHVSHMRS GDFYSSEKSL TLDKACKVNI
210 220 230 240 250
EFVAKNGEVT VLKKGLALQE GEIIDSMFMS KKQLCAYLED EMNDAKETGV
260 270 280 290 300
MFSFHVKATM MKVSHPIVFG HAVKVYYKDL FEKHGKLFDE LGVNPNDGLS
310 320 330 340 350
SVYEHIEKLP ASIKEEILSD MHACYEKRPE LAMVDSAKGI SNLHTPNEVI
360 370 380 390 400
VDASMPAMIR AGGKMWGPDG KMKDTKAVMP ESTFARIYQE IINFCKTHGE
410 420 430 440 450
FDPTTMGTVP NVGLMAQKAE EYGSHDKTFE MKADGSTRIV DEEGNVLLEM
460 470 480 490 500
DVEEGDIWRM CQVKDAPIQD WVKLAVKRAR LSNTPAVFWL DKYRPHENEL
510 520 530 540 550
IKKVEKYLKD HDLTGVDIKI KSQTRAMRYT LERILRGKDT ISVTGNILRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMAGGGLF ETGAGGSAPK HVKQLIEENH
610 620 630 640 650
LRWDSLGEFL ALCASLEHTA ISDDNAKAAV LAKTLDEATA KLLDTGKSPS
660 670 680 690 700
RKTGELDNRG SHFYLALYWA QALAEQTEDE ALQAHFQPLA ASLTENEEKI
710 720 730 740
VGTLTTEQWH AVDIGGYYKP DVDKVREVMR PSEIFNEALA SLK
Length:743
Mass (Da):82,427
Last modified:November 28, 2012 - v1
Checksum:iC6EC019216DC833D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003230 Genomic DNA. Translation: AFT67605.1.
RefSeqiWP_015006375.1. NC_018697.1.

Genome annotation databases

EnsemblBacteriaiAFT67605; AFT67605; Q91_1570.
KEGGicyq:Q91_1570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003230 Genomic DNA. Translation: AFT67605.1.
RefSeqiWP_015006375.1. NC_018697.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFT67605; AFT67605; Q91_1570.
KEGGicyq:Q91_1570.

Phylogenomic databases

KOiK00031.
OMAiNSGQMWG.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the pyrene-degrading bacterium Cycloclasticus sp. strain P1."
    Lai Q., Li W., Wang B., Yu Z., Shao Z.
    J. Bacteriol. 194:6677-6677(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P1Imported.

Entry informationi

Entry nameiK0C4Y6_CYCSP
AccessioniPrimary (citable) accession number: K0C4Y6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: July 22, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.