K0C4Y6 (K0C4Y6_CYCSP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase EMBL AFT67605.1

Gene names

Ordered Locus Names:

Q91_1570 EMBL AFT67605.1

Organism

Cycloclasticus sp. (strain P1) [Complete proteome] [HAMAP] EMBL AFT67605.1

Taxonomic identifier

385025 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Piscirickettsiaceae › Cycloclasticus

Protein attributes

Sequence length	743 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	134 – 141	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	352	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	550	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	554	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	147	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	549	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	257	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	422	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	K0C4Y6 [UniParc]. Last modified November 28, 2012. Version 1. Checksum: C6EC019216DC833D	FASTA	743	82,427
	10 20 30 40 50 60 MTVKKSKIIY TLTDEAPLLA TASFLPIVEA FAGAAGIDVE VSDISLASRV LATFADQLPD 70 80 90 100 110 120 DQKVPDALSE LGRLTQNPET NIIKLPNISA SVPQLKAIIN ELQGKGFDIP NYPEDPQTDE 130 140 150 160 170 180 EKALQQKYGK VLGSAVNPVL REGNSDRRAP KAVKEYAKKN PHSMGKWSQA SRTHVSHMRS 190 200 210 220 230 240 GDFYSSEKSL TLDKACKVNI EFVAKNGEVT VLKKGLALQE GEIIDSMFMS KKQLCAYLED 250 260 270 280 290 300 EMNDAKETGV MFSFHVKATM MKVSHPIVFG HAVKVYYKDL FEKHGKLFDE LGVNPNDGLS 310 320 330 340 350 360 SVYEHIEKLP ASIKEEILSD MHACYEKRPE LAMVDSAKGI SNLHTPNEVI VDASMPAMIR 370 380 390 400 410 420 AGGKMWGPDG KMKDTKAVMP ESTFARIYQE IINFCKTHGE FDPTTMGTVP NVGLMAQKAE 430 440 450 460 470 480 EYGSHDKTFE MKADGSTRIV DEEGNVLLEM DVEEGDIWRM CQVKDAPIQD WVKLAVKRAR 490 500 510 520 530 540 LSNTPAVFWL DKYRPHENEL IKKVEKYLKD HDLTGVDIKI KSQTRAMRYT LERILRGKDT 550 560 570 580 590 600 ISVTGNILRD YLTDLFPILE LGTSAKMLSI VPLMAGGGLF ETGAGGSAPK HVKQLIEENH 610 620 630 640 650 660 LRWDSLGEFL ALCASLEHTA ISDDNAKAAV LAKTLDEATA KLLDTGKSPS RKTGELDNRG 670 680 690 700 710 720 SHFYLALYWA QALAEQTEDE ALQAHFQPLA ASLTENEEKI VGTLTTEQWH AVDIGGYYKP 730 740 DVDKVREVMR PSEIFNEALA SLK

References

[1]	"Complete genome sequence of the pyrene-degrading bacterium Cycloclasticus sp. strain P1." Lai Q., Li W., Wang B., Yu Z., Shao Z. J. Bacteriol. 194:6677-6677(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: P1 EMBL AFT67605.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003230 Genomic DNA. Translation: AFT67605.1.
RefSeq	YP_006838108.1. NC_018697.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AFT67605; AFT67605; Q91_1570.
GeneID	13772762.
KEGG	cyq:Q91_1570.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00031.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

K0C4Y6_CYCSP

Accession

Primary (citable) accession number: K0C4Y6

Entry history

Integrated into UniProtKB/TrEMBL:	November 28, 2012
Last sequence update:	November 28, 2012
Last modified:	April 3, 2013
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)