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K0C1N1 (K0C1N1_CYCSP) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFT66408.1
Ordered Locus Names:Q91_0368 EMBL AFT66408.1
OrganismCycloclasticus sp. (strain P1) [Complete proteome] [HAMAP] EMBL AFT66408.1
Taxonomic identifier385025 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeCycloclasticus

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain109 – 304196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding135 – 19056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2581Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2711Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2731Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
K0C1N1 [UniParc].

Last modified November 28, 2012. Version 1.
Checksum: 5C5B5376BB0CBEC3

FASTA31233,618
        10         20         30         40         50         60 
MSTIQSAKSF GKVAVAMGGH AAERDISLLS GEAVLSALKS QGVDAIKFDT AASDIMELKE 

        70         80         90        100        110        120 
KGIDRVFNIM HGRGGEDGQL QGALELIGIP YTGSGVLGSA LGMDKLRTKN CWLGAGLPTP 

       130        140        150        160        170        180 
KWMVLEKESD IDACVVALGF PVMVKPALEG SSLGMAKANT IEQLREAYKK AMKFTCDVMA 

       190        200        210        220        230        240 
EQWVEGAEYT VAVLADKALP VIRLETPNEF YDYEAKYQAE TTQYHCPCGL TAEQEQALQH 

       250        260        270        280        290        300 
LSIKAFKLLA GEGWGRVDLM LDAQGKPQLL EINTVPGMTD HSLVPMAAKQ AGIDFNTLVW 

       310 
QILETSFAKE GA 

« Hide

References

[1]"Complete Genome Sequence of the Pyrene-Degrading Bacterium Cycloclasticus sp. Strain P1."
Lai Q., Li W., Wang B., Yu Z., Shao Z.
J. Bacteriol. 194:6677-6677(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: P1 EMBL AFT66408.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003230 Genomic DNA. Translation: AFT66408.1.
RefSeqYP_006836911.1. NC_018697.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFT66408; AFT66408; Q91_0368.
GeneID13773183.
KEGGcyq:Q91_0368.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK0C1N1_CYCSP
AccessionPrimary (citable) accession number: K0C1N1
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: June 11, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)