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K0B9Y6

- K0B9Y6_9ARCH

UniProt

K0B9Y6 - K0B9Y6_9ARCH

Protein

DNA ligase

Gene

lig

Organism
Candidatus Nitrosopumilus sp. AR2
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei250 – 2501ATPUniRule annotation
    Active sitei252 – 2521N6-AMP-lysine intermediateUniRule annotation
    Binding sitei257 – 2571ATPUniRule annotation
    Binding sitei272 – 2721ATPUniRule annotation
    Binding sitei302 – 3021ATPUniRule annotation
    Binding sitei342 – 3421ATPUniRule annotation
    Binding sitei417 – 4171ATPUniRule annotation
    Binding sitei423 – 4231ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    ORF Names:NSED_06105Imported
    OrganismiCandidatus Nitrosopumilus sp. AR2Imported
    Taxonomic identifieri1229909 [NCBI]
    Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
    ProteomesiUP000006100: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    K0B9Y6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYSILAESL NKMESTTKRL ELTQHLVELF EKTPHDVISK IVYLIQGKLR    50
    PDFEGIELGV AEKLAIRAIS KSSGIPIKKI EDEYRKGGDL GHASTVILEQ 100
    KTQTTFLVED ITVERVYDTL FKIAKLGGTR SQDMKMKYIS SLLNDATPLE 150
    ASYILKILLG TLRLGIAENT VMDALAIAFS GNKENRKKLQ YAYNVSSDLG 200
    KVAETIATKG LEGIEEFEII LFNPIRPMLA DRVKSEEEAI EKMGNEFAAE 250
    YKLDGERVQL HIEGDKVELF SRSLERIESY YPDIIEKIPK NIQADNIILE 300
    AEAVAINENT GEFLPFQELM HRRRKYKIEK AVTEYPITVN FFDILYCNGK 350
    SCIDLSYKER REKLEKHVKE DEFAKYIPMK IVKNQSEIED FMENSINAGS 400
    EGLMLKMLDK PYQAGSRGSH WLKLKREYRN ELGDSLDLVV IGGFFGKGRR 450
    TGNYGTLLLA TYDEDEDTFP SICKVGTGFS DESLDQLYQI LHPKVSIKKN 500
    PRIISDMEAD VWFEPELVIE VVASEITLSP IHKAAFNEIR KDAGLALRFP 550
    KFTGKIRVEK AAEDASTNEE VITLYKGQKK VAHDKNLM 588
    Length:588
    Mass (Da):66,801
    Last modified:November 28, 2012 - v1
    Checksum:i9659BA7D4AB3A814
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003843 Genomic DNA. Translation: AFS83023.1.
    RefSeqiYP_006775965.1. NC_018656.1.

    Genome annotation databases

    EnsemblBacteriaiAFS83023; AFS83023; NSED_06105.
    GeneIDi13697016.
    KEGGinir:NSED_06105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003843 Genomic DNA. Translation: AFS83023.1 .
    RefSeqi YP_006775965.1. NC_018656.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFS83023 ; AFS83023 ; NSED_06105 .
    GeneIDi 13697016.
    KEGGi nir:NSED_06105.

    Phylogenomic databases

    KOi K10747.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Draft Genome Sequence of an Ammonia-Oxidizing Archaeon, "Candidatus Nitrosopumilus sediminis" AR2, from Svalbard in the Arctic Circle."
      Park S.J., Kim J.G., Jung M.Y., Kim S.J., Cha I.T., Ghai R., Martin-Cuadrado A.B., Rodriguez-Valera F., Rhee S.K.
      J. Bacteriol. 194:6948-6949(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AR2Imported.

    Entry informationi

    Entry nameiK0B9Y6_9ARCH
    AccessioniPrimary (citable) accession number: K0B9Y6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3