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Protein

DNA ligase

Gene

lig

Organism
Candidatus Nitrosopumilus sediminis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei250ATPUniRule annotation1
Active sitei252N6-AMP-lysine intermediateUniRule annotation1
Binding sitei257ATPUniRule annotation1
Binding sitei272ATPUniRule annotation1
Binding sitei302ATPUniRule annotation1
Binding sitei342ATPUniRule annotation1
Binding sitei417ATPUniRule annotation1
Binding sitei423ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNIT1229909:G1HAJ-1244-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
ORF Names:NSED_06105Imported
OrganismiCandidatus Nitrosopumilus sediminisImported
Taxonomic identifieri1229909 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
Proteomesi
  • UP000006100 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini330 – 463DNA_LIGASE_A3InterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

K0B9Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYSILAESL NKMESTTKRL ELTQHLVELF EKTPHDVISK IVYLIQGKLR
60 70 80 90 100
PDFEGIELGV AEKLAIRAIS KSSGIPIKKI EDEYRKGGDL GHASTVILEQ
110 120 130 140 150
KTQTTFLVED ITVERVYDTL FKIAKLGGTR SQDMKMKYIS SLLNDATPLE
160 170 180 190 200
ASYILKILLG TLRLGIAENT VMDALAIAFS GNKENRKKLQ YAYNVSSDLG
210 220 230 240 250
KVAETIATKG LEGIEEFEII LFNPIRPMLA DRVKSEEEAI EKMGNEFAAE
260 270 280 290 300
YKLDGERVQL HIEGDKVELF SRSLERIESY YPDIIEKIPK NIQADNIILE
310 320 330 340 350
AEAVAINENT GEFLPFQELM HRRRKYKIEK AVTEYPITVN FFDILYCNGK
360 370 380 390 400
SCIDLSYKER REKLEKHVKE DEFAKYIPMK IVKNQSEIED FMENSINAGS
410 420 430 440 450
EGLMLKMLDK PYQAGSRGSH WLKLKREYRN ELGDSLDLVV IGGFFGKGRR
460 470 480 490 500
TGNYGTLLLA TYDEDEDTFP SICKVGTGFS DESLDQLYQI LHPKVSIKKN
510 520 530 540 550
PRIISDMEAD VWFEPELVIE VVASEITLSP IHKAAFNEIR KDAGLALRFP
560 570 580
KFTGKIRVEK AAEDASTNEE VITLYKGQKK VAHDKNLM
Length:588
Mass (Da):66,801
Last modified:November 28, 2012 - v1
Checksum:i9659BA7D4AB3A814
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003843 Genomic DNA Translation: AFS83023.1
RefSeqiWP_014965393.1, NC_018656.1

Genome annotation databases

EnsemblBacteriaiAFS83023; AFS83023; NSED_06105
GeneIDi13697016
KEGGinir:NSED_06105
PATRICifig|1229909.8.peg.1343

Similar proteinsi

Entry informationi

Entry nameiK0B9Y6_9ARCH
AccessioniPrimary (citable) accession number: K0B9Y6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: May 23, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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