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K0B9Y6

- K0B9Y6_9ARCH

UniProt

K0B9Y6 - K0B9Y6_9ARCH

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Protein
DNA ligase
Gene
lig, NSED_06105
Organism
Candidatus Nitrosopumilus sp. AR2
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei250 – 2501ATP By similarityUniRule annotation
Active sitei252 – 2521N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei257 – 2571ATP By similarityUniRule annotation
Binding sitei272 – 2721ATP By similarityUniRule annotation
Binding sitei302 – 3021ATP By similarityUniRule annotation
Binding sitei342 – 3421ATP By similarityUniRule annotation
Binding sitei417 – 4171ATP By similarityUniRule annotation
Binding sitei423 – 4231ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
ORF Names:NSED_06105Imported
OrganismiCandidatus Nitrosopumilus sp. AR2Imported
Taxonomic identifieri1229909 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
ProteomesiUP000006100: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

K0B9Y6-1 [UniParc]FASTAAdd to Basket

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MEYSILAESL NKMESTTKRL ELTQHLVELF EKTPHDVISK IVYLIQGKLR    50
PDFEGIELGV AEKLAIRAIS KSSGIPIKKI EDEYRKGGDL GHASTVILEQ 100
KTQTTFLVED ITVERVYDTL FKIAKLGGTR SQDMKMKYIS SLLNDATPLE 150
ASYILKILLG TLRLGIAENT VMDALAIAFS GNKENRKKLQ YAYNVSSDLG 200
KVAETIATKG LEGIEEFEII LFNPIRPMLA DRVKSEEEAI EKMGNEFAAE 250
YKLDGERVQL HIEGDKVELF SRSLERIESY YPDIIEKIPK NIQADNIILE 300
AEAVAINENT GEFLPFQELM HRRRKYKIEK AVTEYPITVN FFDILYCNGK 350
SCIDLSYKER REKLEKHVKE DEFAKYIPMK IVKNQSEIED FMENSINAGS 400
EGLMLKMLDK PYQAGSRGSH WLKLKREYRN ELGDSLDLVV IGGFFGKGRR 450
TGNYGTLLLA TYDEDEDTFP SICKVGTGFS DESLDQLYQI LHPKVSIKKN 500
PRIISDMEAD VWFEPELVIE VVASEITLSP IHKAAFNEIR KDAGLALRFP 550
KFTGKIRVEK AAEDASTNEE VITLYKGQKK VAHDKNLM 588
Length:588
Mass (Da):66,801
Last modified:November 28, 2012 - v1
Checksum:i9659BA7D4AB3A814
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003843 Genomic DNA. Translation: AFS83023.1.
RefSeqiYP_006775965.1. NC_018656.1.

Genome annotation databases

EnsemblBacteriaiAFS83023; AFS83023; NSED_06105.
GeneIDi13697016.
KEGGinir:NSED_06105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003843 Genomic DNA. Translation: AFS83023.1 .
RefSeqi YP_006775965.1. NC_018656.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFS83023 ; AFS83023 ; NSED_06105 .
GeneIDi 13697016.
KEGGi nir:NSED_06105.

Phylogenomic databases

KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Draft Genome Sequence of an Ammonia-Oxidizing Archaeon, "Candidatus Nitrosopumilus sediminis" AR2, from Svalbard in the Arctic Circle."
    Park S.J., Kim J.G., Jung M.Y., Kim S.J., Cha I.T., Ghai R., Martin-Cuadrado A.B., Rodriguez-Valera F., Rhee S.K.
    J. Bacteriol. 194:6948-6949(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AR2Imported.

Entry informationi

Entry nameiK0B9Y6_9ARCH
AccessioniPrimary (citable) accession number: K0B9Y6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 3, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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