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K0AAA4

- K0AAA4_EXIAB

UniProt

K0AAA4 - K0AAA4_EXIAB

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Protein

Alanine racemase

Gene

alr

Organism
Exiguobacterium antarcticum (strain B7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei3 – 31Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei95 – 951SubstrateUniRule annotation
Active sitei221 – 2211Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei268 – 2681Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:Eab7_0468Imported
OrganismiExiguobacterium antarcticum (strain B7)Imported
Taxonomic identifieri1087448 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
ProteomesiUP000006274: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliK0AAA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

K0AAA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKNNAYNLG MIEMVATLME AGVRHFAVAE VYEAIEIKTN FPDSYVLAMN
60 70 80 90 100
PASHFKEVRL HGVALGIPSL DWLTRHQADL SGIELHLKVN VGMNRFGVSS
110 120 130 140 150
LQEALSVLET VCEQDLALTG LYTHFPLADE PGADHDGQVE RFLEITDVLR
160 170 180 190 200
TKQSFPYIHA ENSATIVKHD PRLAFCNYVR PGIFLFGYSP IEKMDWLIPS
210 220 230 240 250
LRMTTEVVEI RQVEAGEHVG YGTSYTAPET IRVAVLPVGY GDGVVRGRSS
260 270 280 290 300
LPVIINGKRY PIISKLFMSH TFIAIDSTVQ IGDKVVLYGD GIEIDDITRT
310 320
GTANNSEQMC ARSWRLTHRY L
Length:321
Mass (Da):35,799
Last modified:November 28, 2012 - v1
Checksum:i34AE777F6ABF7544
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003063 Genomic DNA. Translation: AFS69626.1.
RefSeqiYP_006790234.1. NC_018665.1.

Genome annotation databases

EnsemblBacteriaiAFS69626; AFS69626; Eab7_0468.
GeneIDi13713240.
KEGGiean:Eab7_0468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003063 Genomic DNA. Translation: AFS69626.1 .
RefSeqi YP_006790234.1. NC_018665.1.

3D structure databases

ProteinModelPortali K0AAA4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFS69626 ; AFS69626 ; Eab7_0468 .
GeneIDi 13713240.
KEGGi ean:Eab7_0468.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B7Imported.

Entry informationi

Entry nameiK0AAA4_EXIAB
AccessioniPrimary (citable) accession number: K0AAA4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 29, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3