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K0AAA4

- K0AAA4_EXIAB

UniProt

K0AAA4 - K0AAA4_EXIAB

Protein

Alanine racemase

Gene

alr

Organism
Exiguobacterium antarcticum (strain B7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei3 – 31Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei95 – 951SubstrateUniRule annotation
    Active sitei221 – 2211Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei268 – 2681Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:Eab7_0468Imported
    OrganismiExiguobacterium antarcticum (strain B7)Imported
    Taxonomic identifieri1087448 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillales Family XII. Incertae SedisExiguobacterium
    ProteomesiUP000006274: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei3 – 31N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliK0AAA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    K0AAA4-1 [UniParc]FASTAAdd to Basket

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    MVKNNAYNLG MIEMVATLME AGVRHFAVAE VYEAIEIKTN FPDSYVLAMN    50
    PASHFKEVRL HGVALGIPSL DWLTRHQADL SGIELHLKVN VGMNRFGVSS 100
    LQEALSVLET VCEQDLALTG LYTHFPLADE PGADHDGQVE RFLEITDVLR 150
    TKQSFPYIHA ENSATIVKHD PRLAFCNYVR PGIFLFGYSP IEKMDWLIPS 200
    LRMTTEVVEI RQVEAGEHVG YGTSYTAPET IRVAVLPVGY GDGVVRGRSS 250
    LPVIINGKRY PIISKLFMSH TFIAIDSTVQ IGDKVVLYGD GIEIDDITRT 300
    GTANNSEQMC ARSWRLTHRY L 321
    Length:321
    Mass (Da):35,799
    Last modified:November 28, 2012 - v1
    Checksum:i34AE777F6ABF7544
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003063 Genomic DNA. Translation: AFS69626.1.
    RefSeqiYP_006790234.1. NC_018665.1.

    Genome annotation databases

    EnsemblBacteriaiAFS69626; AFS69626; Eab7_0468.
    GeneIDi13713240.
    KEGGiean:Eab7_0468.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003063 Genomic DNA. Translation: AFS69626.1 .
    RefSeqi YP_006790234.1. NC_018665.1.

    3D structure databases

    ProteinModelPortali K0AAA4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFS69626 ; AFS69626 ; Eab7_0468 .
    GeneIDi 13713240.
    KEGGi ean:Eab7_0468.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B7Imported.

    Entry informationi

    Entry nameiK0AAA4_EXIAB
    AccessioniPrimary (citable) accession number: K0AAA4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3