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J9ZFJ9

- J9ZFJ9_ECO14

UniProt

J9ZFJ9 - J9ZFJ9_ECO14

Protein

Xylose isomerase

Gene

xylA

Organism
Escherichia coli O104:H4 (strain 2009EL-2050)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei101 – 1011UniRule annotation
    Active sitei104 – 1041UniRule annotation
    Metal bindingi232 – 2321Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 2UniRule annotation
    Metal bindingi271 – 2711Magnesium 2UniRule annotation
    Metal bindingi296 – 2961Magnesium 1UniRule annotation
    Metal bindingi307 – 3071Magnesium 2UniRule annotation
    Metal bindingi309 – 3091Magnesium 2UniRule annotation
    Metal bindingi339 – 3391Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotation
    Ordered Locus Names:O3M_01065Imported
    OrganismiEscherichia coli O104:H4 (strain 2009EL-2050)Imported
    Taxonomic identifieri1134782 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000006090: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliJ9ZFJ9.
    SMRiJ9ZFJ9. Positions 2-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    KOiK01805.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    J9ZFJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAYFDQLDR VRYEGSKSSN PLAFRHYNPD ELVLGKRMEE HLRFAACYWH    50
    TFCWNGADMF GVGAFNRPWQ QPGEALALAK RKADVAFEFF HKLHVPFYCF 100
    HDVDVSPEGA SLKEYINNFA QMVDVLAGKQ EESGVKLLWG TANCFTNPRY 150
    GAGAATNPDP EVFSWAATQV VTAMEATHKL GGENYVLWGG REGYETLLNT 200
    DLRQEREQLG RFMQMVVEHK HKIGFQGTLL IEPKPQEPTK HQYDYDAATV 250
    YGFLKQFGLE KEIKLNIEAN HATLAGHSFH HEIATAIALG LFGSVDANRG 300
    DAQLGWDTDQ FPNSVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY 350
    DLFYGHIGAM DTMALALKIA ARMIEDGELD KRIAQRYSGW NSELGQQILK 400
    GQMSLADLAK YAQEHNLSPV HQSGRQEQLE NLVNHYLFDK 440
    Length:440
    Mass (Da):49,719
    Last modified:November 28, 2012 - v1
    Checksum:i6E21039B6EC0561F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003297 Genomic DNA. Translation: AFS54936.1.
    RefSeqiYP_006767896.1. NC_018650.1.

    Genome annotation databases

    EnsemblBacteriaiAFS54936; AFS54936; O3M_01065.
    GeneIDi13690121.
    KEGGiesm:O3M_01065.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003297 Genomic DNA. Translation: AFS54936.1 .
    RefSeqi YP_006767896.1. NC_018650.1.

    3D structure databases

    ProteinModelPortali J9ZFJ9.
    SMRi J9ZFJ9. Positions 2-439.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFS54936 ; AFS54936 ; O3M_01065 .
    GeneIDi 13690121.
    KEGGi esm:O3M_01065.

    Phylogenomic databases

    KOi K01805.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic comparison of Escherichia coli O104:H4 isolates from 2009 and 2011 reveals plasmid, and prophage heterogeneity, including Shiga toxin encoding phage stx2."
      Threat Characterization Consortium
      Ahmed S.A., Awosika J., Baldwin C., Bishop-Lilly K.A., Biswas B., Broomall S., Chain P.S., Chertkov O., Chokoshvili O., Coyne S., Davenport K., Detter J.C., Dorman W., Erkkila T.H., Folster J.P., Frey K.G., George M., Gleasner C.
      , Henry M., Hill K.K., Hubbard K., Insalaco J., Johnson S., Kitzmiller A., Krepps M., Lo C.C., Luu T., McNew L.A., Minogue T., Munk C.A., Osborne B., Patel M., Reitenga K.G., Rosenzweig C.N., Shea A., Shen X., Strockbine N., Tarr C., Teshima H., van Gieson E., Verratti K., Wolcott M., Xie G., Sozhamannan S., Gibbons H.S.
      PLoS ONE 7:E48228-E48228(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2009EL-2050Imported.

    Entry informationi

    Entry nameiJ9ZFJ9_ECO14
    AccessioniPrimary (citable) accession number: J9ZFJ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3