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Protein

Alanine racemase

Gene

LFML04_2348

Organism
Leptospirillum ferriphilum (strain ML-04)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei148 – 1481SubstrateUniRule annotation
Active sitei288 – 2881Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei336 – 3361Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:LFML04_2348Imported
OrganismiLeptospirillum ferriphilum (strain ML-04)Imported
Taxonomic identifieri1048260 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeLeptospirillum
ProteomesiUP000006177: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliJ9ZF19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J9ZF19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESESSLIEI PGYAGRDLSR SRLIVDLDAL SNNLEWIRSR LPSSIEILPV
60 70 80 90 100
VKADAYGHGM LPVAKNFVEK GVPALGVMGL EEGVRLRKAE ISAKVIVMGG
110 120 130 140 150
ILPSELEDCI AFGLTPVIHN CELLEAALDL SRKMEVHIHL KFDVGMGRLG
160 170 180 190 200
FLPEDISWVC DKIGMESSLR IEGVMSHFPE GEKISETSRQ IGIFGCMVDE
210 220 230 240 250
LWDRGALCDR PFVIHLANSA AFLSGQYSVT DKKNRAWEKY ARYWIRPGIL
260 270 280 290 300
LYGIPVDPLP LPGLKPAMEI QARLISLKTL SEGSRISYGG TLSLSRKTRV
310 320 330 340 350
GVLGMGYADG LPRELSNWGW ASRMGQKFPF LGRVCMDMVM VDVTDAESPV
360 370 380 390 400
CLGDWMTVLG NGEDSSMSAW DIAGRIRSIP YEIVCRMGNR SPRFYSRKAS

SSENFG
Length:406
Mass (Da):44,851
Last modified:November 28, 2012 - v1
Checksum:iACABD93C1AC26550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002919 Genomic DNA. Translation: AFS54538.1.
RefSeqiYP_006767498.1. NC_018649.1.

Genome annotation databases

EnsemblBacteriaiAFS54538; AFS54538; LFML04_2348.
GeneIDi13688421.
KEGGilfi:LFML04_2348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002919 Genomic DNA. Translation: AFS54538.1.
RefSeqiYP_006767498.1. NC_018649.1.

3D structure databases

ProteinModelPortaliJ9ZF19.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFS54538; AFS54538; LFML04_2348.
GeneIDi13688421.
KEGGilfi:LFML04_2348.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome of Leptospirillum ferriphilum ML-04 provides insight into its physiology and environmental adaptation."
    Mi S., Song J., Lin J., Che Y., Zheng H., Lin J.
    J. Microbiol. 49:890-901(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ML-04Imported.

Entry informationi

Entry nameiJ9ZF19_LEPFM
AccessioniPrimary (citable) accession number: J9ZF19
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: March 4, 2015
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.