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Protein

Alanine racemase

Gene

HIMB59_00013440

Organism
alpha proteobacterium HIMB59
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Active sitei251 – 2511Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei299 – 2991Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:HIMB59_00013440Imported
Organismialpha proteobacterium HIMB59Imported
Taxonomic identifieri744985 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR11 cluster
ProteomesiUP000006097 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliJ9Z2K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J9Z2K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLDNKQIY INRQYLINNY DILKKKAENS KIMSVIKGDA YGHGIQQCSD
60 70 80 90 100
VLEKNGCNHF YVARLDDAIS LRKKHQKKIN IYLLSGTISK EICGYIKRYE
110 120 130 140 150
ITPIINNLKQ LEIFNRFIPH TKFVLHFDTG MNRLGFKIEE INQIKELSIL
160 170 180 190 200
KNVQFLMTHL SSADEQNIKE CRFQLNQLKR INKLFNKPLS IANSSGIFLG
210 220 230 240 250
KSFHLNYVRP GKSLYGINPF LKKSFGLKGV MSIYAPILQI TSIKKGQTVG
260 270 280 290 300
YSKTFKAKKN IKVATVDFGY SDGYLRSGSN RTKVFIDGII CNVLGRVSMD
310 320 330 340 350
LITIDVSNVD ENSLYLGKPV EILGENQSCE DLALELGTNE HEVLISLGKN

SKKVYI
Length:356
Mass (Da):40,519
Last modified:November 27, 2012 - v1
Checksum:iDF4B7BF28D2E72D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003801 Genomic DNA. Translation: AFS49520.1.
RefSeqiWP_014955351.1. NC_018644.1.
YP_006758697.1. NC_018644.1.

Genome annotation databases

EnsemblBacteriaiAFS49520; AFS49520; HIMB59_00013440.
KEGGiapc:HIMB59_00013440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003801 Genomic DNA. Translation: AFS49520.1.
RefSeqiWP_014955351.1. NC_018644.1.
YP_006758697.1. NC_018644.1.

3D structure databases

ProteinModelPortaliJ9Z2K9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFS49520; AFS49520; HIMB59_00013440.
KEGGiapc:HIMB59_00013440.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HIMB59Imported.

Entry informationi

Entry nameiJ9Z2K9_9PROT
AccessioniPrimary (citable) accession number: J9Z2K9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 27, 2012
Last sequence update: November 27, 2012
Last modified: March 31, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.