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Protein

Alanine racemase

Gene

HIMB59_00013440

Organism
alpha proteobacterium HIMB59
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (HIMB59_00013440)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Active sitei251Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei299Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:HIMB59_00013440Imported
Organismialpha proteobacterium HIMB59Imported
Taxonomic identifieri744985 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaPelagibacteralesPelagibacteraceae
Proteomesi
  • UP000006097 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliJ9Z2K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 356Ala_racemase_CInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01775.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

J9Z2K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLDNKQIY INRQYLINNY DILKKKAENS KIMSVIKGDA YGHGIQQCSD
60 70 80 90 100
VLEKNGCNHF YVARLDDAIS LRKKHQKKIN IYLLSGTISK EICGYIKRYE
110 120 130 140 150
ITPIINNLKQ LEIFNRFIPH TKFVLHFDTG MNRLGFKIEE INQIKELSIL
160 170 180 190 200
KNVQFLMTHL SSADEQNIKE CRFQLNQLKR INKLFNKPLS IANSSGIFLG
210 220 230 240 250
KSFHLNYVRP GKSLYGINPF LKKSFGLKGV MSIYAPILQI TSIKKGQTVG
260 270 280 290 300
YSKTFKAKKN IKVATVDFGY SDGYLRSGSN RTKVFIDGII CNVLGRVSMD
310 320 330 340 350
LITIDVSNVD ENSLYLGKPV EILGENQSCE DLALELGTNE HEVLISLGKN

SKKVYI
Length:356
Mass (Da):40,519
Last modified:November 28, 2012 - v1
Checksum:iDF4B7BF28D2E72D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003801 Genomic DNA. Translation: AFS49520.1.
RefSeqiWP_014955351.1. NC_018644.1.

Genome annotation databases

EnsemblBacteriaiAFS49520; AFS49520; HIMB59_00013440.
KEGGiapc:HIMB59_00013440.
PATRICifig|744985.3.peg.1327.

Entry informationi

Entry nameiJ9Z2K9_9PROT
AccessioniPrimary (citable) accession number: J9Z2K9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 27, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported