J9Z2K9 (J9Z2K9_9PROT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine racemase RuleBase RU000608 HAMAP-Rule MF_01201
EC=5.1.1.1 RuleBase RU000608 HAMAP-Rule MF_01201

Gene names

ORF Names:

HIMB59_00013440 EMBL AFS49520.1

Organism

alpha proteobacterium HIMB59 EMBL AFS49520.1

Taxonomic identifier

744985 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › unclassified Alphaproteobacteria › SAR11 cluster

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201
Catalytic activity	L-alanine = D-alanine. SAAS SAAS020622 RuleBase RU000608 HAMAP-Rule MF_01201
Cofactor	Pyridoxal phosphate By similarity. SAAS SAAS020622 RuleBase RU000608 HAMAP-Rule MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. SAAS SAAS020622 HAMAP-Rule MF_01201
Sequence similarities	Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Ontologies

Keywords
Ligand	Pyridoxal phosphate SAAS SAAS020622 RuleBase RU000608 HAMAP-Rule MF_01201
Molecular function	Isomerase SAAS SAAS020622 RuleBase RU000608 HAMAP-Rule MF_01201
Gene Ontology (GO)
Biological_process	D-alanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	37	1	Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
	Active site	251	1	Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
	Binding site	133	1	Substrate By similarity HAMAP-Rule MF_01201
	Binding site	299	1	Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201
Amino acid modifications
	Modified residue	37	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

	Sequence		Length	Mass (Da)
	J9Z2K9 [UniParc]. Last modified November 28, 2012. Version 1. Checksum: DF4B7BF28D2E72D5	FASTA	356	40,519
	10 20 30 40 50 60 MKKLDNKQIY INRQYLINNY DILKKKAENS KIMSVIKGDA YGHGIQQCSD VLEKNGCNHF 70 80 90 100 110 120 YVARLDDAIS LRKKHQKKIN IYLLSGTISK EICGYIKRYE ITPIINNLKQ LEIFNRFIPH 130 140 150 160 170 180 TKFVLHFDTG MNRLGFKIEE INQIKELSIL KNVQFLMTHL SSADEQNIKE CRFQLNQLKR 190 200 210 220 230 240 INKLFNKPLS IANSSGIFLG KSFHLNYVRP GKSLYGINPF LKKSFGLKGV MSIYAPILQI 250 260 270 280 290 300 TSIKKGQTVG YSKTFKAKKN IKVATVDFGY SDGYLRSGSN RTKVFIDGII CNVLGRVSMD 310 320 330 340 350 LITIDVSNVD ENSLYLGKPV EILGENQSCE DLALELGTNE HEVLISLGKN SKKVYI

References

[1]	Grote J., Thrash C., Huggett M.J., Landry Z., Carini P., Giovannoni S.J., Rappe M.S., Brinkac L., Kim M., Beeson K., Ferriera S., Sutton G., Friedman R., Venter J.C. Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: HIMB59 EMBL AFS49520.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003801 Genomic DNA. Translation: AFS49520.1.
RefSeq	YP_006758697.1. NC_018644.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AFS49520; AFS49520; HIMB59_00013440.
GeneID	13676120.
KEGG	apc:HIMB59_00013440.
Phylogenomic databases
KO	K01775.
Enzyme and pathway databases
UniPathway	UPA00042; UER00497.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
HAMAP	MF_01201. Ala_racemase.
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

J9Z2K9_9PROT

Accession

Primary (citable) accession number: J9Z2K9

Entry history

Integrated into UniProtKB/TrEMBL:	November 28, 2012
Last sequence update:	November 28, 2012
Last modified:	May 29, 2013
This is version 6 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)