Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

J9YVG8 (J9YVG8_9PROT) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
ORF Names:HIMB5_00002020 EMBL AFS46971.1
Organismalpha proteobacterium HIMB5 [Complete proteome] EMBL AFS46971.1
Taxonomic identifier859653 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSAR11 cluster

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain100 – 297198ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding130 – 18354ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2521Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2641Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2641Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
J9YVG8 [UniParc].

Last modified November 28, 2012. Version 1.
Checksum: 35B767FF6C9770C4

FASTA30334,751
        10         20         30         40         50         60 
MKKKILILSG GISKERSISL DTGNQVAKEL KKKYSVKICE PNNDLEKNIK KFKPHKIFNA 

        70         80         90        100        110        120 
LHGQFGEDGY IQTIIENYKI PYTHSGVIAS AIAMDKDISK RIFLKNKILT PKYINFTFDK 

       130        140        150        160        170        180 
NPKELTKTVE KILKFPVVVK PINEGSSVNV FICTKKNFLK KVELLKSYKK IMIEEFIGGR 

       190        200        210        220        230        240 
EIQVAILGKK KLGAIELKPK RKFYDYTAKY KKSAKTKHII PVQLPKKKLD LVLNISLKAH 

       250        260        270        280        290        300 
NLIGCKGVTR SDFKFYNNKF YLLEINTQPG MTKLSLVPEI AAYRGISFFD LLEWMLKDAS 


INR 

« Hide

References

[1]Grote J., Thrash C., Huggett M.J., Landry Z., Carini P., Giovannoni S.J., Rappe M.S., Brinkac L., Kim M., Beeson K., Ferriera S., Sutton G., Friedman R., Venter J.C.
Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HIMB5 EMBL AFS46971.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003809 Genomic DNA. Translation: AFS46971.1.
RefSeqYP_006756148.1. NC_018643.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFS46971; AFS46971; HIMB5_00002020.
GeneID13673464.
KEGGapm:HIMB5_00002020.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJ9YVG8_9PROT
AccessionPrimary (citable) accession number: J9YVG8
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: February 19, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)