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J9YBT2

- J9YBT2_ALTMA

UniProt

J9YBT2 - J9YBT2_ALTMA

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Protein
Acetyltransferase component of pyruvate dehydrogenase complex
Gene
MASE_14020
Organism
Alteromonas macleodii ATCC 27126
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:MASE_14020Imported
OrganismiAlteromonas macleodii ATCC 27126Imported
Taxonomic identifieri529120 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeAlteromonas
ProteomesiUP000006102: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 3 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotations

Phylogenomic databases

KOiK00627.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 3 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 3 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 3 hits.
PS00189. LIPOYL. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J9YBT2-1 [UniParc]FASTAAdd to Basket

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MSDIQKIIVP DVGGDEVEVI ELCVAVGDNI EADEGVVTVE SDKASMDIPA    50
PFEGEIVSLT VSVGDKIKEG DVIGEMKVAN GDSADKGASE ENASDESSKE 100
DAPKQEEAPK DESKSEAAPA ASGSSEVIEV AVPDIGSDDE VDVIDVLVSV 150
GDTIEKEDGL ITLETDKATM DVPSTHAGTV KEVFISTGDK VKEGTVVIKL 200
EVAGSGSSSS ESASSDASSE ASAPAAQESA KQESAPAASS GSETIEVAVP 250
DIGEDGEVDV IDVLVSAGDT VEKEDGLITL ETDKATMDVP STHAGTIKEV 300
FIKAGDKVKQ GTLVVKLETS GGSSSSAAEK PAEAPKQEET KQDSQQEETQ 350
QASQQEASQG RSPVPPAPEA KNTGKAHASP SVRRIAREFG VDLTQVNGSG 400
PKNRILKEDV QAYVKAELAK PRTAAASGSA PVGDNVLQIV PVKPVDHSKF 450
GEIEEQKLSR IQKISGPFLH RNWATIPHVT QFDEADITEV EEFRKEQNAY 500
HAKIKSGLKI TPLVFVMKAV AKALEKYEVF NSSLSDDGES LIIKKFINIG 550
IAVETPGGLV VPVIRDVNKK GIEQLSQELI DTSKKAREGK LKAADMQGGT 600
FTISSLGGIG GTAFTPIVNA PEVAILGVSK SEMKPKWNGK EFEPRLMVPL 650
SLSYDHRVID GAVGARFSTE VAANLTDLRR IIL 683
Length:683
Mass (Da):71,912
Last modified:November 28, 2012 - v1
Checksum:i67B13B76E78A3848
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003841 Genomic DNA. Translation: AFS38308.1.
RefSeqiWP_014950395.1. NC_018632.1.
YP_006748862.1. NC_018632.1.

Genome annotation databases

EnsemblBacteriaiAFS38308; AFS38308; MASE_14020.
GeneIDi13669711.
KEGGiamac:MASE_14020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003841 Genomic DNA. Translation: AFS38308.1 .
RefSeqi WP_014950395.1. NC_018632.1.
YP_006748862.1. NC_018632.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFS38308 ; AFS38308 ; MASE_14020 .
GeneIDi 13669711.
KEGGi amac:MASE_14020.

Phylogenomic databases

KOi K00627.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 3 hits.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 3 hits.
TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 3 hits.
PS00189. LIPOYL. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of two ecotypes of the marine planktonic copiotroph Alteromonas macleodii suggests alternative lifestyles associated with different kinds of particulate organic matter."
    Ivars-Martinez E., Martin-Cuadrado A.B., D'Auria G., Mira A., Ferriera S., Johnson J., Friedman R., Rodriguez-Valera F.
    ISME J. 2:1194-1212(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27126Imported.

Entry informationi

Entry nameiJ9YBT2_ALTMA
AccessioniPrimary (citable) accession number: J9YBT2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 3, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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