ID   J9W630_MYCIP            Unreviewed;       351 AA.
AC   J9W630;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE            EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN   ORFNames=MIP_00682 {ECO:0000313|EMBL:AFS12464.1};
OS   Mycobacterium indicus pranii (strain DSM 45239 / MTCC 9506).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1232724 {ECO:0000313|EMBL:AFS12464.1, ECO:0000313|Proteomes:UP000007329};
RN   [1] {ECO:0000313|EMBL:AFS12464.1, ECO:0000313|Proteomes:UP000007329}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MTCC 9506 {ECO:0000313|EMBL:AFS12464.1};
RX   PubMed=17912347; DOI=10.1371/journal.pone.0000968;
RA   Ahmed N., Saini V., Raghuvanshi S., Khurana J.P., Tyagi A.K., Tyagi A.K.,
RA   Hasnain S.E.;
RT   "Molecular analysis of a leprosy immunotherapeutic bacillus provides
RT   insights into Mycobacterium evolution.";
RL   PLoS ONE 2:E968-E968(2007).
RN   [2] {ECO:0000313|EMBL:AFS12464.1, ECO:0000313|Proteomes:UP000007329}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45239 / MTCC 9506 {ECO:0000313|Proteomes:UP000007329};
RX   PubMed=22965120; DOI=10.1093/nar/gks793;
RA   Saini V., Raghuvanshi S., Khurana J.P., Ahmed N., Hasnain S.E., Tyagi A.K.,
RA   Tyagi A.K.;
RT   "Massive gene acquisitions in Mycobacterium indicus pranii provide a
RT   perspective on mycobacterial evolution.";
RL   Nucleic Acids Res. 40:10832-10850(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|ARBA:ARBA00007572}.
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DR   EMBL; CP002275; AFS12464.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9W630; -.
DR   KEGG; mid:MIP_00682; -.
DR   PATRIC; fig|1232724.3.peg.487; -.
DR   HOGENOM; CLU_008325_4_1_11; -.
DR   Proteomes; UP000007329; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd07905; Adenylation_DNA_ligase_LigC; 1.
DR   CDD; cd07970; OBF_DNA_ligase_LigC; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR044119; Adenylation_LigC-like.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR044117; OBF_LigC-like.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   PANTHER; PTHR45674:SF9; DNA LIGASE 3; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AFS12464.1}.
FT   DOMAIN          109..243
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   351 AA;  39353 MW;  7EF20D9CF2022FB9 CRC64;
     MPPVSPMLAK SVRAIPPHAS YEPKWDGFRS ICFRDGDDVE LGSRNERPMT RYFPELVAAV
     RAELPERCVI DGEIVIATDH GLDFEALQQR IHPADSRVRM LAEATPASFI AFDLLALGGD
     DYTRRPFSER RAALVDAVGG SGRSIHVTPA TTDLGTAQRW FDEFEGAGLD GVIAKPLDVT
     YQPDKRVMFK IKHERTADCV VAGYRVHKSG ADAIGSLLLG LYQDDGQLAS VGVIGAFPMA
     ERRRLFAELQ PLVTDFADHP WNWAAHEAGE RTPRKNEYSR WNAGKDLSFV PLRPERVVEV
     RYDHMEGRRF RHTAQFNRWR PDRDPRSCTY EQLEQPVTFS LGEIVPGLGP G
//