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J9W4U7

- J9W4U7_LACBU

UniProt

J9W4U7 - J9W4U7_LACBU

Protein

Thymidine kinase

Gene

tdk

Organism
Lactobacillus buchneri CD034
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (28 Nov 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei117 – 1171Proton acceptorUniRule annotation
    Metal bindingi174 – 1741ZincUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation
    Metal bindingi211 – 2111ZincUniRule annotation
    Metal bindingi214 – 2141ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 478ATPUniRule annotation
    Nucleotide bindingi116 – 1194ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    ORF Names:LBUCD034_0986Imported
    OrganismiLactobacillus buchneri CD034Imported
    Taxonomic identifieri1071400 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000007332: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    J9W4U7-1 [UniParc]FASTAAdd to Basket

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    MRVLANFLII IDFQNFFCIM EEKLLRKKVD ILAQLFYRYG AMNSGKTIEI    50
    IKVAHNYEEQ NKSVIIMTSA LDTREKQGMI ESRIGLERKA EPIREDTNVF 100
    DLVQELNPHA SCILIDEAQF LKKKHVMELA RIVDELNVPV MAFGLKNDFQ 150
    NNLFEGSKYL LLYADKIEEM KTICWFCGKK AIMNLRFHNG EPVYEGEQIQ 200
    MGGNESYYPV CRKHYYNPPI K 221
    Length:221
    Mass (Da):25,829
    Last modified:November 28, 2012 - v1
    Checksum:i1872649C9212D512
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003043 Genomic DNA. Translation: AFS00030.1.
    RefSeqiWP_013727670.1. NC_018610.1.
    YP_006725612.1. NC_018610.1.

    Genome annotation databases

    EnsemblBacteriaiAFS00030; AFS00030; LBUCD034_0986.
    GeneIDi13655960.
    KEGGilbn:LBUCD034_0986.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003043 Genomic DNA. Translation: AFS00030.1 .
    RefSeqi WP_013727670.1. NC_018610.1.
    YP_006725612.1. NC_018610.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFS00030 ; AFS00030 ; LBUCD034_0986 .
    GeneIDi 13655960.
    KEGGi lbn:LBUCD034_0986.

    Phylogenomic databases

    KOi K00857.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights into the completely annotated genome of Lactobacillus buchneri CD034, a strain isolated from stable grass silage."
      Heinl S., Wibberg D., Eikmeyer F., Szczepanowski R., Blom J., Linke B., Goesmann A., Grabherr R., Schwab H., Puhler A., Schluter A.
      J. Biotechnol. 161:153-166(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CD034Imported.

    Entry informationi

    Entry nameiJ9W4U7_LACBU
    AccessioniPrimary (citable) accession number: J9W4U7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2012
    Last sequence update: November 28, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3