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Protein

Probable acetate kinase

Gene

CNAG_06432

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable acetate kinase (CNAG_06432)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12MagnesiumUniRule annotation1
Binding sitei19ATPUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Active sitei159Proton donor/acceptorUniRule annotation1
Sitei192Transition state stabilizerUniRule annotation1
Sitei253Transition state stabilizerUniRule annotation1
Metal bindingi416MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 224ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.2.1. 1723.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
ORF Names:CNAG_06432Imported
OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
Taxonomic identifieri235443 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000010091 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiFungiDB:CNAG_06432.

Subcellular locationi

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H0PX-ray1.89A/B1-430[»]
SMRiJ9W3A6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

OrthoDBiEOG092C2KVJ.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

J9W3A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDKAEYLLA INCGSSSIKG KLFAIPSFEL LANLAVTNIS SSDERVKIKT
60 70 80 90 100
TWEEGKGKDS EEEADYGDKI RYASLVPILL DHLTNSTHVK KEEIKYVCHR
110 120 130 140 150
VVHGGMHDKG IRVVKGHEEG LMEMDKLSEF APLHNHRAVL AVKSCIDALP
160 170 180 190 200
HHTSLLLFDT IFHRTIAPEV YTYALPPPDT ELTMPLRKYG FHGLSYASIV
210 220 230 240 250
QSLAEHLKKP SDQINVVVAH LGSGSSSCCI KNGKSIDTSM GLTPLEGLLG
260 270 280 290 300
GTRSGTIDPT AIFHHTEDAA SDANVGDFTV SKAEIILNKN SGFKALAGTT
310 320 330 340 350
NFGHIIQNLD PSKCSEEDHE KAKLTYAVFL DRLLNFVAQY LFKLLSEVPI
360 370 380 390 400
ESIDGLVFSG GIGEKGAELR RDVLKKLAWL GAEVDEEANN SNSGGAVKCI
410 420 430
TKEGSKLKGW VVETDEEGWM ARMAKEEFGF
Length:430
Mass (Da):47,039
Last modified:November 28, 2012 - v1
Checksum:iF2835D3B6D7C8B05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003832 Genomic DNA. Translation: AFR98670.1.
RefSeqiXP_012053491.1. XM_012198101.1.

Genome annotation databases

EnsemblFungiiAFR98670; AFR98670; CNAG_06432.
GeneIDi23889639.

Similar proteinsi

Entry informationi

Entry nameiJ9W3A6_CRYNH
AccessioniPrimary (citable) accession number: J9W3A6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 27, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported