Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyl-coenzyme A synthetase

Gene

CNAG_00797

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei218Coenzyme ACombined sources1
Binding sitei297ATPCombined sources1
Binding sitei334ATPCombined sources1
Binding sitei441ATPCombined sources1
Binding sitei527ATPCombined sources1
Binding sitei542ATPCombined sources1
Binding sitei552Coenzyme ACombined sources1
Binding sitei615Coenzyme ACombined sources1
Binding sitei620Coenzyme ACombined sources1
Binding sitei640ATPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi289 – 293ATPCombined sources5
Nucleotide bindingi412 – 414ATPCombined sources3
Nucleotide bindingi436 – 437ATPCombined sources2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
LigandATP-bindingUniRule annotationCombined sources, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
ORF Names:CNAG_00797Imported
OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
Taxonomic identifieri235443 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000010091 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:CNAG_00797

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IFIX-ray1.95A/B/C2-680[»]
5K85X-ray2.30A/B/C2-680[»]
5K8FX-ray2.45A/B/C2-680[»]
5U29X-ray2.50A/B/C2-680[»]
5VPVX-ray2.60A/B/C2-680[»]
ProteinModelPortaliJ9VFT1
SMRiJ9VFT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 108ACAS_NInterPro annotationAdd BLAST47
Domaini110 – 549AMP-bindingInterPro annotationAdd BLAST440
Domaini558 – 640AMP-binding_CInterPro annotationAdd BLAST83

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

OrthoDBiEOG092C0Z1N

Family and domain databases

CDDicd05966 ACS, 1 hit
InterProiView protein in InterPro
IPR011904 Ac_CoA_lig
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
TIGRFAMsiTIGR02188 Ac_CoA_lig_AcsA, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

J9VFT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTEVAPGV HHVHPLPDSV PESEDLFAPP PRMQGKEGRP KPHIGPNYES
60 70 80 90 100
YVKEWAKTVG PNSDEWWAAK ARETLDWYDD FKTVRAGGFE HGDVQWFPEG
110 120 130 140 150
TLNAAYNCLD RHYYKNPKKT AIIYEADEPS ESREVSYEEL MQETCRVANV
160 170 180 190 200
LKSYGVKKGD AVSIYLPMTW QAAAAFLACA RIGAIHSAVF AGFSAESLRD
210 220 230 240 250
RVNDCECKVL ITTDEGRRGG KTIATKQIVD AALQQCPLVE NVLVLRRTGN
260 270 280 290 300
KVPMTEGRDK WWDEECAKMP AYCPCERMAS EDPLFILYTS GSTGKPKGVV
310 320 330 340 350
HSTAGYLLGT ALTLKYVFDA HPDDRFACMA DIGWITGHSY IIYGPLANGI
360 370 380 390 400
TTAVFESTPV YPTPSRYWDF VDKWKATQLY TAPTAIRLLR RMGEDHVKNH
410 420 430 440 450
DLSSLRVLGS VGEPINPEAW HWYNDFAGKN QCAIVDTYWM TETGSISIAP
460 470 480 490 500
LPGAISTKPG SATFPFFGMD VDIIDPQTGQ VLEGNDVEGV LVARRPWPSI
510 520 530 540 550
ARTVYRDHKR YLETYMKPYP GYFFFGDGAA RDYDGYMWIK GRVDDVINVS
560 570 580 590 600
GHRLSTAEVE SALILHKGVA ETAVVGCADD LTGQAVYAFV TMKPEFDLKA
610 620 630 640 650
TKEADLSKEL AIQVRKVIGP FAAPKKIYLV SDLPKTRSGK IMRRVLRKIV
660 670 680
AGEGDQLGDL SSIADPQIVE EVKQKVTGSA
Length:680
Mass (Da):75,482
Last modified:November 28, 2012 - v1
Checksum:iFB6FB354C55EFBD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003820 Genomic DNA Translation: AFR92928.1
RefSeqiXP_012046967.1, XM_012191577.1

Genome annotation databases

EnsemblFungiiAFR92928; AFR92928; CNAG_00797
GeneIDi23884574

Similar proteinsi

Entry informationi

Entry nameiJ9VFT1_CRYNH
AccessioniPrimary (citable) accession number: J9VFT1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: June 20, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health