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J9TPU1 (J9TPU1_BRAPL) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFR69377.1
ORF Names:B2904_orf19 EMBL AFR69377.1
OrganismBrachyspira pilosicoli B2904 [Complete proteome] EMBL AFR69377.1
Taxonomic identifier1133568 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011127

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011127

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011127

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011127.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011127

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain121 – 317197ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding147 – 19953ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2711Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2861Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
J9TPU1 [UniParc].

Last modified November 28, 2012. Version 1.
Checksum: 21A0BE5061395911

FASTA32336,560
        10         20         30         40         50         60 
MLLTNELKNK ILKKFEGKKI AVLHGGISDE REVSLRSGKN VFEALTSYKE LKDSTILIDV 

        70         80         90        100        110        120 
KDHYELVETL KKEDVEYCYN ILHGTFGEDG TIQGLLDCLN IKYTGENTLV SSLCMNKVYT 

       130        140        150        160        170        180 
KRIWLSSNIS TVDFQLLEDA IKNNNISFNF PIILKPISSG SSVGVSLIKT KEEFDNIVKD 

       190        200        210        220        230        240 
IKDTHNYFLE PYIKGKEVTV GLVRDNDDIY VFPILGINPK NEIYDYDAKY TPGKTEMEIP 

       250        260        270        280        290        300 
AKLDKEIEKK LIENCKKAYD VLGCEGLCRI DAIISDDGFI NLMEVNTQGG MTNTSDIPAM 

       310        320 
ARNINMPFED VVLYILSLSY RNV 

« Hide

References

[1]"Comparative genomics of Brachyspira pilosicoli strains: genome rearrangements, reductions and correlation of genetic compliment with phenotypic diversity."
Mappley L.J., Black M.L., Abuoun M., Darby A.C., Woodward M.J., Parkhill J., Turner A.K., Bellgard M.I., La T., Phillips N.D., La Ragione R.M., Hampson D.J.
BMC Genomics 13:454-454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B2904 EMBL AFR69377.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003490 Genomic DNA. Translation: AFR69377.1.
RefSeqYP_006706125.1. NC_018607.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFR69377; AFR69377; B2904_orf19.
GeneID13632952.
KEGGbpj:B2904_orf19.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJ9TPU1_BRAPL
AccessionPrimary (citable) accession number: J9TPU1
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: February 19, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)