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Protein

Histone deacetylase

Gene

HDAC2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. chromatin DNA binding Source: Ensembl
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  6. poly(A) RNA binding Source: Ensembl
  7. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  8. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  9. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. ATP-dependent chromatin remodeling Source: Ensembl
  2. cardiac muscle cell development Source: Ensembl
  3. circadian regulation of gene expression Source: Ensembl
  4. dendrite development Source: Ensembl
  5. embryonic digit morphogenesis Source: Ensembl
  6. epidermal cell differentiation Source: Ensembl
  7. eyelid development in camera-type eye Source: Ensembl
  8. fungiform papilla formation Source: Ensembl
  9. hair follicle placode formation Source: Ensembl
  10. hippocampus development Source: Ensembl
  11. maintenance of chromatin silencing Source: Ensembl
  12. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  13. negative regulation of cardiac muscle cell proliferation Source: Ensembl
  14. negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  15. negative regulation of neuron projection development Source: Ensembl
  16. negative regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  17. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  18. odontogenesis of dentin-containing tooth Source: Ensembl
  19. positive regulation of cell proliferation Source: Ensembl
  20. positive regulation of oligodendrocyte differentiation Source: Ensembl
  21. positive regulation of proteolysis Source: Ensembl
  22. positive regulation of receptor biosynthetic process Source: Ensembl
  23. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  24. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  25. regulation of protein deacetylation Source: Ensembl
  26. regulation of protein kinase B signaling Source: Ensembl
  27. regulation of sarcomere organization Source: Ensembl
  28. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_182569. Factors involved in megakaryocyte development and platelet production.
REACT_217695. NoRC negatively regulates rRNA expression.
REACT_240096. HDACs deacetylate histones.
REACT_248081. RNA Polymerase I Transcription Initiation.
REACT_250308. p75NTR negatively regulates cell cycle via SC1.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:HDAC2Imported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 12

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. ESC/E(Z) complex Source: Ensembl
  2. heterochromatin Source: Ensembl
  3. NuRD complex Source: Ensembl
  4. replication fork Source: Ensembl
  5. Sin3 complex Source: Ensembl
  6. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000062889.
OrthoDBiEOG7DNNTW.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

J9P9H5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSI
60 70 80 90 100
RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA GAVKLNRQQT
110 120 130 140 150
DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH
160 170 180 190 200
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR
210 220 230 240 250
DGIDDESYGQ IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK
260 270 280 290 300
GHAKCVEVVK TFNLPLLMLG GGGYTIRNVA RCWTYETAVA LDCEIPNELP
310 320 330 340 350
YNDYFEYFGP DFKLHISPSN MTNQNTPEYM EKIKQRLFEN LRMLPHAPGV
360 370 380 390 400
QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE FSDSEDEGEG
410 420 430 440 450
GRRNVADHKK GAKKARIEED KKETEDKKAD VKEEDKSKDS SGEKTDTKGA

KSEQLSNP
Length:458
Mass (Da):51,911
Last modified:October 31, 2012 - v1
Checksum:i63BE2350FAB1D95C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03008633 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCAFT00000046686; ENSCAFP00000042408; ENSCAFG00000004049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03008633 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000046686; ENSCAFP00000042408; ENSCAFG00000004049.

Phylogenomic databases

GeneTreeiENSGT00530000062889.
OrthoDBiEOG7DNNTW.

Enzyme and pathway databases

ReactomeiREACT_182569. Factors involved in megakaryocyte development and platelet production.
REACT_217695. NoRC negatively regulates rRNA expression.
REACT_240096. HDACs deacetylate histones.
REACT_248081. RNA Polymerase I Transcription Initiation.
REACT_250308. p75NTR negatively regulates cell cycle via SC1.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
    Broad Sequencing Platform
    Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
    , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
    Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BoxerImported.
  2. Ensembl
    Submitted (SEP-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.

Entry informationi

Entry nameiJ9P9H5_CANFA
AccessioniPrimary (citable) accession number: J9P9H5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: January 7, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.