J9P7P5 (J9P7P5_CANFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Uncharacterized protein Ensembl ENSCAFP00000041684

Gene names

Name:

SETDB1 Ensembl ENSCAFP00000041684

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome] Ensembl ENSCAFP00000041684

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	1293 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS007728 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine. RuleBase RU004542
Subcellular location	Nucleus By similarity RuleBase RU004542.
Sequence similarities	Contains 1 SET domain. SAAS SAAS007728 Contains 1 post-SET domain. RuleBase RU004541 Contains 1 pre-SET domain. RuleBase RU004542
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSCAFP00000041684

Ontologies

Keywords
Cellular component	Chromosome SAAS SAAS007728 Nucleus RuleBase RU004542 SAAS SAAS007728
Molecular function	Methyltransferase RuleBase RU004541 RuleBase RU004542 SAAS SAAS007728 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	J9P7P5 [UniParc]. Last modified October 31, 2012. Version 1. Checksum: 0BD448C6E45FDF93	FASTA	1,293	143,169
	10 20 30 40 50 60 MSSLPGCIGL DAATAAVESE EIAELQQAVV EELGISMEEL RQFIDEELEK MDCVQQRKKQ 70 80 90 100 110 120 LAELETWVIQ KESEVAHVDQ LFDDASRAVT NCESLVKDFY SKLGLQYRDS SSEDETSRPT 130 140 150 160 170 180 EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL 190 200 210 220 230 240 HKGTLSQMSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGPGKKY KVKFDNKGKS 250 260 270 280 290 300 LLSGNHIAYD YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 310 320 330 340 350 360 YASYVTQSEL YPICRPLKKT WEDIEDISCR DFIEEYITAY PNRPMVLLKS GQLIKTEWEG 370 380 390 400 410 420 TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASALE KKHGGQLRTR 430 440 450 460 470 480 PNMGAVRSKG PVVQYTQDLA STGTQFKPVE PPQPTAPPAP PIPPAPPVPP LSPQAGDNDL 490 500 510 520 530 540 ESQLAQSRKQ VAKKSTSFRP GSVGSGHSSP TSPALSENVP AGKPGSNQTY RSPLGSTASA 550 560 570 580 590 600 SAAPPAPPAP PAFHGMLERA PAEPSYRAPM EKLFYLPHVC SYTCLSRVRP MRSAQYRGKN 610 620 630 640 650 660 PLLVPLLYDF RRMTARRRVN RKMGFHVIYK TPCGLCLRTM QEIERYLFET GCDFLFLEMF 670 680 690 700 710 720 CLDPYVLVDR KFQPYKPFYY ILDITYGKED VPLSCVNEID TTPPPQVAYS KERIPGKGVF 730 740 750 760 770 780 INTGPEFLVG CDCKDGCRDK SKCACHQLTI QATACTPGGQ INPNSGYQYK RLEECLPTGV 790 800 810 820 830 840 YECNKRCKCD PNMCTNRLVQ HGLQVRLQLF KTQNKGWGIR CLDDIAKGSF VCIYAGKILT 850 860 870 880 890 900 DDFADKEGLE MGDEYFANLD HIESVENFKE GYESDAPCSS DSSGVDLKDQ EDGNSGTEDP 910 920 930 940 950 960 EESNDDSSDD NFCKDEDFST SSVWRSYATR RQTRGQKENG LSEIASKDSR PPDLGPPHIP 970 980 990 1000 1010 1020 IPPVIPVGGC NPPSSEETPK NKVASWLSCN SVSEGGFADS DSRSSFKTSE GGEGRAGGGR 1030 1040 1050 1060 1070 1080 GEAEKASTSG LGFKEEGDIK QAKKEDPDDR SKMSVLTESS RNYGYNPSPM KLEGLRRPPS 1090 1100 1110 1120 1130 1140 KTSMHQSRRL MASAQSNTDD VLTLSSSTES EGESGTSRKP TTGQTSATAV DSDDIQTISS 1150 1160 1170 1180 1190 1200 GSEADDFEDK KNMSGPTKRQ VAVKSTRGFA LKSTHGIAIK STNMASVEKG ESAPVRKNTR 1210 1220 1230 1240 1250 1260 QFYDGEESCY IIDAKLEGNL GRYLNHSCSP NLFVQNVFVD THDLRFPWVA FFASKRIRAG 1270 1280 1290 TELTWDYNYE VGSVEGKELL CCCGAIECRG RLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence, comparative analysis and haplotype structure of the domestic dog." Broad Sequencing Platform Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R. , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S. Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Boxer Ensembl ENSCAFP00000041684.
[2]	Ensembl Submitted (SEP-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Boxer Ensembl ENSCAFP00000041684.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAEX03011052 Genomic DNA. No translation available. AAEX03011053 Genomic DNA. No translation available. AAEX03011054 Genomic DNA. No translation available.
RefSeq	XP_540304.3. XM_540304.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000049297; ENSCAFP00000041684; ENSCAFG00000023501.
GeneID	483186.
KEGG	cfa:483186.
Organism-specific databases
CTD	9869.
Phylogenomic databases
GeneTree	ENSGT00690000101898.
KO	K11421.
Family and domain databases
InterPro	IPR016177. DNA-bd_integrase-typ. IPR025796. Hist-Lys_N-MeTrfase_SETDB1. IPR001739. Methyl_CpG_DNA-bd. IPR003616. Post-SET_dom. IPR007728. Pre-SET_dom. IPR003606. Pre-SET_Zn-bd_sub. IPR001214. SET_dom. IPR002999. Tudor. [Graphical view]
Pfam	PF01429. MBD. 1 hit. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00391. MBD. 1 hit. SM00508. PostSET. 1 hit. SM00468. PreSET. 1 hit. SM00317. SET. 1 hit. SM00333. TUDOR. 2 hits. [Graphical view]
SUPFAM	SSF54171. DNA-binding_integrase-type. 1 hit.
PROSITE	PS50982. MBD. 1 hit. PS50868. POST_SET. 1 hit. PS50867. PRE_SET. 1 hit. PS51573. SAM_MT43_SUVAR39_1. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

J9P7P5_CANFA

Accession

Primary (citable) accession number: J9P7P5

Entry history

Integrated into UniProtKB/TrEMBL:	October 31, 2012
Last sequence update:	October 31, 2012
Last modified:	March 6, 2013
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)