Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

J9P7P5

- J9P7P5_CANFA

UniProt

J9P7P5 - J9P7P5_CANFA

Protein
Submitted name:

Uncharacterized protein

Gene

SETDB1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (31 Oct 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation
    S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. histone-lysine N-methyltransferase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:SETDB1Imported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 17

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains 1 post-SET domain.
    Contains 1 pre-SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains pre-SET domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117355.
    OrthoDBiEOG7ZD1TG.

    Family and domain databases

    InterProiIPR016177. DNA-bd_dom.
    IPR025796. Hist-Lys_N-MeTrfase_SETDB1.
    IPR001739. Methyl_CpG_DNA-bd.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR003606. Pre-SET_Zn-bd_sub.
    IPR001214. SET_dom.
    IPR002999. Tudor.
    [Graphical view]
    PfamiPF01429. MBD. 1 hit.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00391. MBD. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00468. PreSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00333. TUDOR. 2 hits.
    [Graphical view]
    SUPFAMiSSF54171. SSF54171. 1 hit.
    PROSITEiPS50982. MBD. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51573. SAM_MT43_SUVAR39_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    J9P7P5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLPGCIGL DAATAAVESE EIAELQQAVV EELGISMEEL RQFIDEELEK     50
    MDCVQQRKKQ LAELETWVIQ KESEVAHVDQ LFDDASRAVT NCESLVKDFY 100
    SKLGLQYRDS SSEDETSRPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL 150
    REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLSQMSG ELSKDGDLIV 200
    SMRILGKKRT KTWHKGTLIA IQTVGPGKKY KVKFDNKGKS LLSGNHIAYD 250
    YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 300
    YASYVTQSEL YPICRPLKKT WEDIEDISCR DFIEEYITAY PNRPMVLLKS 350
    GQLIKTEWEG TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS 400
    MKTSSASALE KKHGGQLRTR PNMGAVRSKG PVVQYTQDLA STGTQFKPVE 450
    PPQPTAPPAP PIPPAPPVPP LSPQAGDNDL ESQLAQSRKQ VAKKSTSFRP 500
    GSVGSGHSSP TSPALSENVP AGKPGSNQTY RSPLGSTASA SAAPPAPPAP 550
    PAFHGMLERA PAEPSYRAPM EKLFYLPHVC SYTCLSRVRP MRSAQYRGKN 600
    PLLVPLLYDF RRMTARRRVN RKMGFHVIYK TPCGLCLRTM QEIERYLFET 650
    GCDFLFLEMF CLDPYVLVDR KFQPYKPFYY ILDITYGKED VPLSCVNEID 700
    TTPPPQVAYS KERIPGKGVF INTGPEFLVG CDCKDGCRDK SKCACHQLTI 750
    QATACTPGGQ INPNSGYQYK RLEECLPTGV YECNKRCKCD PNMCTNRLVQ 800
    HGLQVRLQLF KTQNKGWGIR CLDDIAKGSF VCIYAGKILT DDFADKEGLE 850
    MGDEYFANLD HIESVENFKE GYESDAPCSS DSSGVDLKDQ EDGNSGTEDP 900
    EESNDDSSDD NFCKDEDFST SSVWRSYATR RQTRGQKENG LSEIASKDSR 950
    PPDLGPPHIP IPPVIPVGGC NPPSSEETPK NKVASWLSCN SVSEGGFADS 1000
    DSRSSFKTSE GGEGRAGGGR GEAEKASTSG LGFKEEGDIK QAKKEDPDDR 1050
    SKMSVLTESS RNYGYNPSPM KLEGLRRPPS KTSMHQSRRL MASAQSNTDD 1100
    VLTLSSSTES EGESGTSRKP TTGQTSATAV DSDDIQTISS GSEADDFEDK 1150
    KNMSGPTKRQ VAVKSTRGFA LKSTHGIAIK STNMASVEKG ESAPVRKNTR 1200
    QFYDGEESCY IIDAKLEGNL GRYLNHSCSP NLFVQNVFVD THDLRFPWVA 1250
    FFASKRIRAG TELTWDYNYE VGSVEGKELL CCCGAIECRG RLL 1293
    Length:1,293
    Mass (Da):143,169
    Last modified:October 31, 2012 - v1
    Checksum:i0BD448C6E45FDF93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03011052 Genomic DNA. No translation available.
    AAEX03011053 Genomic DNA. No translation available.
    AAEX03011054 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSCAFT00000049297; ENSCAFP00000041684; ENSCAFG00000023501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03011052 Genomic DNA. No translation available.
    AAEX03011053 Genomic DNA. No translation available.
    AAEX03011054 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000049297 ; ENSCAFP00000041684 ; ENSCAFG00000023501 .

    Phylogenomic databases

    GeneTreei ENSGT00750000117355.
    OrthoDBi EOG7ZD1TG.

    Family and domain databases

    InterProi IPR016177. DNA-bd_dom.
    IPR025796. Hist-Lys_N-MeTrfase_SETDB1.
    IPR001739. Methyl_CpG_DNA-bd.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR003606. Pre-SET_Zn-bd_sub.
    IPR001214. SET_dom.
    IPR002999. Tudor.
    [Graphical view ]
    Pfami PF01429. MBD. 1 hit.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00391. MBD. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00468. PreSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00333. TUDOR. 2 hits.
    [Graphical view ]
    SUPFAMi SSF54171. SSF54171. 1 hit.
    PROSITEi PS50982. MBD. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51573. SAM_MT43_SUVAR39_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
      Broad Sequencing Platform
      Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
      , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
      Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BoxerImported.
    2. Ensembl
      Submitted (SEP-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: BoxerImported.

    Entry informationi

    Entry nameiJ9P7P5_CANFA
    AccessioniPrimary (citable) accession number: J9P7P5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2012
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3