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Protein

Histone-lysine N-methyltransferase

Gene

SETDB1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CFA-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:SETDB1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiJ9P7P5.

Expressioni

Gene expression databases

BgeeiENSCAFG00000023501.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini596 – 667MBDInterPro annotationAdd BLAST72
Domaini729 – 802Pre-SETInterPro annotationAdd BLAST74
Domaini805 – 1268SETInterPro annotationAdd BLAST464
Domaini1277 – 1293Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili37 – 64Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1141. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.

Family and domain databases

InterProiView protein in InterPro
IPR016177. DNA-bd_dom.
IPR025796. Hist-Lys_N-MeTrfase_SETDB1.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
IPR002999. Tudor.
PfamiView protein in Pfam
PF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00391. MBD. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00333. TUDOR. 2 hits.
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiView protein in PROSITE
PS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51573. SAM_MT43_SUVAR39_1. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

J9P7P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLPGCIGL DAATAAVESE EIAELQQAVV EELGISMEEL RQFIDEELEK
60 70 80 90 100
MDCVQQRKKQ LAELETWVIQ KESEVAHVDQ LFDDASRAVT NCESLVKDFY
110 120 130 140 150
SKLGLQYRDS SSEDETSRPT EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL
160 170 180 190 200
REAMAALRKS AQDVQKFMDA VNKKSSSQDL HKGTLSQMSG ELSKDGDLIV
210 220 230 240 250
SMRILGKKRT KTWHKGTLIA IQTVGPGKKY KVKFDNKGKS LLSGNHIAYD
260 270 280 290 300
YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG
310 320 330 340 350
YASYVTQSEL YPICRPLKKT WEDIEDISCR DFIEEYITAY PNRPMVLLKS
360 370 380 390 400
GQLIKTEWEG TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS
410 420 430 440 450
MKTSSASALE KKHGGQLRTR PNMGAVRSKG PVVQYTQDLA STGTQFKPVE
460 470 480 490 500
PPQPTAPPAP PIPPAPPVPP LSPQAGDNDL ESQLAQSRKQ VAKKSTSFRP
510 520 530 540 550
GSVGSGHSSP TSPALSENVP AGKPGSNQTY RSPLGSTASA SAAPPAPPAP
560 570 580 590 600
PAFHGMLERA PAEPSYRAPM EKLFYLPHVC SYTCLSRVRP MRSAQYRGKN
610 620 630 640 650
PLLVPLLYDF RRMTARRRVN RKMGFHVIYK TPCGLCLRTM QEIERYLFET
660 670 680 690 700
GCDFLFLEMF CLDPYVLVDR KFQPYKPFYY ILDITYGKED VPLSCVNEID
710 720 730 740 750
TTPPPQVAYS KERIPGKGVF INTGPEFLVG CDCKDGCRDK SKCACHQLTI
760 770 780 790 800
QATACTPGGQ INPNSGYQYK RLEECLPTGV YECNKRCKCD PNMCTNRLVQ
810 820 830 840 850
HGLQVRLQLF KTQNKGWGIR CLDDIAKGSF VCIYAGKILT DDFADKEGLE
860 870 880 890 900
MGDEYFANLD HIESVENFKE GYESDAPCSS DSSGVDLKDQ EDGNSGTEDP
910 920 930 940 950
EESNDDSSDD NFCKDEDFST SSVWRSYATR RQTRGQKENG LSEIASKDSR
960 970 980 990 1000
PPDLGPPHIP IPPVIPVGGC NPPSSEETPK NKVASWLSCN SVSEGGFADS
1010 1020 1030 1040 1050
DSRSSFKTSE GGEGRAGGGR GEAEKASTSG LGFKEEGDIK QAKKEDPDDR
1060 1070 1080 1090 1100
SKMSVLTESS RNYGYNPSPM KLEGLRRPPS KTSMHQSRRL MASAQSNTDD
1110 1120 1130 1140 1150
VLTLSSSTES EGESGTSRKP TTGQTSATAV DSDDIQTISS GSEADDFEDK
1160 1170 1180 1190 1200
KNMSGPTKRQ VAVKSTRGFA LKSTHGIAIK STNMASVEKG ESAPVRKNTR
1210 1220 1230 1240 1250
QFYDGEESCY IIDAKLEGNL GRYLNHSCSP NLFVQNVFVD THDLRFPWVA
1260 1270 1280 1290
FFASKRIRAG TELTWDYNYE VGSVEGKELL CCCGAIECRG RLL
Length:1,293
Mass (Da):143,169
Last modified:October 31, 2012 - v1
Checksum:i0BD448C6E45FDF93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03011052 Genomic DNA. No translation available.
AAEX03011053 Genomic DNA. No translation available.
AAEX03011054 Genomic DNA. No translation available.
RefSeqiXP_013976164.1. XM_014120689.1.

Genome annotation databases

EnsembliENSCAFT00000049297; ENSCAFP00000041684; ENSCAFG00000023501.
GeneIDi483186.

Similar proteinsi

Entry informationi

Entry nameiJ9P7P5_CANLF
AccessioniPrimary (citable) accession number: J9P7P5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 27, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported