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J9NZF7

- J9NZF7_CANFA

UniProt

J9NZF7 - J9NZF7_CANFA

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Protein
Submitted name:

Uncharacterized protein

Gene

ASH1L

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. DNA binding Source: InterPro
  3. histone-lysine N-methyltransferase activity Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ASH1LImported
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00770000120575.
KOiK06101.
OrthoDBiEOG7ZPNJ4.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR006560. AWS_dom.
IPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00384. AT_hook. 3 hits.
SM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J9NZF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPRNTAMLG LGSDSEGFSR KSPSALGTGT VVSKREGELE SNTKEEEDLR
60 70 80 90 100
KRNWDRNSEA GKEDGLTDAQ QQFSVKETNF SEGNLKLKIG LQAKRTKKPP
110 120 130 140 150
KNLENYVCRP AIKTTIKHPR KALKGGKMTE EKDEHCPSRR DPSKLYKKTG
160 170 180 190 200
DVAAVECQSE ESIHLHSQGE NSPLSKKLSP GHSEMTDYMN AASSTLVGSR
210 220 230 240 250
DPDLKDRALL NGGTSVTEKL AQLIATCPPS KSSKTKPKKL GSGTSAGLVS
260 270 280 290 300
KDLIRKAGVG SVAGIIHKDL IKKPAISTAV GLVTKDPGKK PVFNATVGLV
310 320 330 340 350
NKDSVKKLGA GTTAVFINKD LGRKPGTVTT VGLLSKDSGK KLGIGIVPGL
360 370 380 390 400
VNKESGKKLG LGTVVGLVNK DLGKKLSSTV GLVAKDCAKK IVANSTMGLV
410 420 430 440 450
TKDMGKKLVS CSMAGLVNKD AINLKAEALL PTQEPLKASC STNISSHENQ
460 470 480 490 500
ELSESLKDST TSKTFEKNVI RQSKESILEK FSVRKEIINL EKEMFNEGTC
510 520 530 540 550
IQQDSFSSND RGPYETSKHE KQPPVYCTSP DFQMGAASDA SMAKSPFSAV
560 570 580 590 600
GESNLPSPSP TVSVNPLTRS PPETSSQLAP NPLLLSPTTE LMEDISESVG
610 620 630 640 650
KNQFTSESTH LNIGHRSVGH SMNIECKGID KELTDSKTAH IDIPRISSSL
660 670 680 690 700
GKKPSLTSES SIHTITPSVV NFTSLFSNKP FLKLGAVSAS DKHCQVAESL
710 720 730 740 750
SSSLQSKPLK KRKGRKARWT KVVARSTCRS PKGLDLERSE LFKSVSCSSL
760 770 780 790 800
SNSNSEPAKF MKNIGPSSFV DHDFLKRRLP KLSKSTTPSL ALLTDSEKPS
810 820 830 840 850
HKAFATHKLS SSMCVSSDLL SDIYKPKRGR PKAKEMPQLE GPPKRTLKIP
860 870 880 890 900
ASKVFSLQSK EEQEPPILQP EIEIPSFKQS LSVSPFPKKR GRPKRQLRSP
910 920 930 940 950
VKMKPPVLSV APFVATESPS KLESESDNHR SSSDFFESED QLQDPDDLDD
960 970 980 990 1000
SHRPAVCSMS DLEMEPDKKI TKRNNGQLMK TIIRKINKMK TLKRKKLLNQ
1010 1020 1030 1040 1050
ILSSSVESSN KGKVQSKLHN TVSSLAATFG SKLGQQINVS KKGTIYIGKR
1060 1070 1080 1090 1100
RGRKPKTVLN GILSGSPTSL AVLEQTAQQA AGSALGQILP PLLPSSASSS
1110 1120 1130 1140 1150
EILPSPVCSQ SSGTSGGQSP VSSDAGFVEP SSVPYLHLHS RQGSMIQTLA
1160 1170 1180 1190 1200
MKKASKGRRR LSPPTLLPNS PSHLSELTSL KEATPSPISE SHSDETIPSD
1210 1220 1230 1240 1250
SGIGTDNNST SDRAEKFCGQ KKRRHSFEHV SLIPPETSTV LSSLKEKHKH
1260 1270 1280 1290 1300
KCKRRNHDYL SYDKMKRQKR KRKKKYPQLR SRQDPDFIAD LEELISRLSE
1310 1320 1330 1340 1350
IRITHRSHHF IPRDLLPTIF RINFNSFYTH PSFPLDPLHY IRKPDLKKKR
1360 1370 1380 1390 1400
GRPPKMREAM AEMPFMHSLS FPLSSTGFYP SYGMPYSPSP LTATPLGLGY
1410 1420 1430 1440 1450
YGRYPPTLYP PPPSPSFTPP LPPPSYMHAG HLLLNPTKYH KKKHKLLRQE
1460 1470 1480 1490 1500
AFLTTSRTPL LSMSTYPSVP PEMAYGWMVE HKHRHRHKHR EHRSSEQPQV
1510 1520 1530 1540 1550
SMDAGSSRSV LESLKRYRFG KETVGERYKH KEKHRCHMSC PHLSPSKSLI
1560 1570 1580 1590 1600
NREEQWVHRE PSESSPLALG LQTPLQIDCS ESSPSLSLGG FTPNSDPASS
1610 1620 1630 1640 1650
DEHTNLFTSA IVQGSCRVSN PNSSGRKKLT DSPGLFSAQD TSLIRPHRKE
1660 1670 1680 1690 1700
PLPSSERAVQ TMTGSQPTSD KSSQRPSEST NCSPTRKRSS SESTSSTVNG
1710 1720 1730 1740 1750
LPSRSPRLLA PGDDSVDSLL QRMVQHEDQE PLEKNLDAVI ASASGPPSSS
1760 1770 1780 1790 1800
PGHSHSKERA LGKPDSLLVP AAPSDSCSSS ISLLSEKLPS SCSPHHIKRS
1810 1820 1830 1840 1850
VVEAMQRQAR KMCNYDKILA TKKNLDHVNK ILKAKKLQRQ ARTGNNFVKR
1860 1870 1880 1890 1900
RPGRPRKCPL QAVVSMQAFQ AARFVSPDAN EGEERAALPL RPDTVTDVIE
1910 1920 1930 1940 1950
AVVQSVNLSP EHKKGLKRKS WLLEEQTKKK QKPFPEEEQE HPKSFTEAAV
1960 1970 1980 1990 2000
EIPSPPETPA KPSEPESTLQ PVLSLIPREK KAPRPPKKKY QKAGLYSDVY
2010 2020 2030 2040 2050
KTTDPKSRLI QLKKEKLEYT PGEHEYGLFP APIHVGKYLR QKRIDFQLPY
2060 2070 2080 2090 2100
DILWQWKHNQ LYKKPDVPLY KKIRSNVYVD VKPLSGYEAT TCNCKKPEDD
2110 2120 2130 2140 2150
TGKGCVDDCL NRMIFAECSP NTCPCGEQCC NQRIQRHEWV QCLERFRAEE
2160 2170 2180 2190 2200
KGWGIRTKEP LKAGQFIIEY LGEVVSEQEF RNRMIEQYHN HSDHYCLNLD
2210 2220 2230 2240 2250
SGMVIDSYRM GNEARFINHS CDPNCEMQKW SVNGVYRIGL YALKDMPAGT
2260 2270 2280 2290 2300
ELTYDYNFHS FNVEKQQLCK CGFEKCRGII GGKSQRVNGL ASSKSSQPVA
2310 2320 2330 2340 2350
THKKSGRSKE KRKSKHKLKK RRGHLSEEPS ENINTPTRLT PQLQMKPMSN
2360 2370 2380 2390 2400
RERNFVLKHH VFLVRNWEKI RQKQEEVKHT SDNLHSASLY TRWNGICRDD
2410 2420 2430 2440 2450
GNIKSDVFMT QFSALQTARS VRTRRLAAAE ENIEVARAAR LAQIFKEICD
2460 2470 2480 2490 2500
GIISYKDSSR QALAAPLLNL PPKKKNADYY EKISEPLDLA TIERQILTGH
2510 2520 2530 2540 2550
YKTVEAFDAD MLKVFRNAEK YYGRKSPIGR DVCRLRKTYY NARHEASAQI
2560 2570 2580 2590 2600
DEIVGETASE ADSSETSVSE KENVHEKDDD VIRCVCGLHK DEGLMIQCDK
2610 2620 2630 2640 2650
CMVWQHCDCM GVNSDVEHYL CEQCDPRPVD REVPMIPRPH YAQPGCVYFI
2660 2670 2680 2690 2700
CLLRDDLLLR QGDCVYLMRD SRRTPDGHPV RQSYRLLSHI NRDKLDIFRI
2710 2720 2730 2740 2750
EKLWKNEKEE RFAFGHHYFR PHETHHSPSR RFYHNELFRV PLYEIIPLEA
2760 2770 2780 2790 2800
VVGTCCVLDL YTYCKGRPKG VKEQDVYICD YRLDKSAHLF YKIHRNRYPV
2810 2820 2830 2840 2850
CTKPYAFDHF PKKLTPKRDF SPHYVPDNYK RNGGRSSWKS ERPKPPLKDL
2860 2870 2880 2890 2900
GQEDDALPLI EEVLASQEQA TNELPSLEEP EREVAPVEVS EGEKKAEEGG
2910 2920 2930 2940 2950
PESQAACTPE ERRHSQRERL NQILLGLLEK IPGKNAIDVT YLLEEGSGRK
2960
LRRRTLFIPE NSFRK
Length:2,965
Mass (Da):331,712
Last modified:October 31, 2012 - v1
Checksum:i0EDFB35848AC29FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005337 Genomic DNA. No translation available.
RefSeqiXP_537251.2. XM_537251.4.

Genome annotation databases

EnsembliENSCAFT00000048670; ENSCAFP00000038677; ENSCAFG00000016944.
GeneIDi480128.
KEGGicfa:480128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03005337 Genomic DNA. No translation available.
RefSeqi XP_537251.2. XM_537251.4.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000048670 ; ENSCAFP00000038677 ; ENSCAFG00000016944 .
GeneIDi 480128.
KEGGi cfa:480128.

Organism-specific databases

CTDi 55870.

Phylogenomic databases

GeneTreei ENSGT00770000120575.
KOi K06101.
OrthoDBi EOG7ZPNJ4.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR017956. AT_hook_DNA-bd_motif.
IPR006560. AWS_dom.
IPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01426. BAH. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00384. AT_hook. 3 hits.
SM00570. AWS. 1 hit.
SM00439. BAH. 1 hit.
SM00297. BROMO. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS51215. AWS. 1 hit.
PS51038. BAH. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
    Broad Sequencing Platform
    Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
    , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
    Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BoxerImported.
  2. Ensembl
    Submitted (SEP-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: BoxerImported.

Entry informationi

Entry nameiJ9NZF7_CANFA
AccessioniPrimary (citable) accession number: J9NZF7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 26, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3