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J9NZF7

- J9NZF7_CANFA

UniProt

J9NZF7 - J9NZF7_CANFA

Protein
Submitted name:

Uncharacterized protein

Gene

ASH1L

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA binding Source: InterPro
    3. histone-lysine N-methyltransferase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:ASH1LImported
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)Imported
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 post-SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114921.
    KOiK06101.
    OrthoDBiEOG7ZPNJ4.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR017956. AT_hook_DNA-bd_motif.
    IPR006560. AWS.
    IPR001025. BAH_dom.
    IPR001487. Bromodomain.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01426. BAH. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00384. AT_hook. 3 hits.
    SM00570. AWS. 1 hit.
    SM00439. BAH. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00249. PHD. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51215. AWS. 1 hit.
    PS51038. BAH. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    J9NZF7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPRNTAMLG LGSDSEGFSR KSPSALGTGT VVSKREGELE SNTKEEEDLR     50
    KRNWDRNSEA GKEDGLTDAQ QQFSVKETNF SEGNLKLKIG LQAKRTKKPP 100
    KNLENYVCRP AIKTTIKHPR KALKGGKMTE EKDEHCPSRR DPSKLYKKTG 150
    DVAAVECQSE ESIHLHSQGE NSPLSKKLSP GHSEMTDYMN AASSTLVGSR 200
    DPDLKDRALL NGGTSVTEKL AQLIATCPPS KSSKTKPKKL GSGTSAGLVS 250
    KDLIRKAGVG SVAGIIHKDL IKKPAISTAV GLVTKDPGKK PVFNATVGLV 300
    NKDSVKKLGA GTTAVFINKD LGRKPGTVTT VGLLSKDSGK KLGIGIVPGL 350
    VNKESGKKLG LGTVVGLVNK DLGKKLSSTV GLVAKDCAKK IVANSTMGLV 400
    TKDMGKKLVS CSMAGLVNKD AINLKAEALL PTQEPLKASC STNISSHENQ 450
    ELSESLKDST TSKTFEKNVI RQSKESILEK FSVRKEIINL EKEMFNEGTC 500
    IQQDSFSSND RGPYETSKHE KQPPVYCTSP DFQMGAASDA SMAKSPFSAV 550
    GESNLPSPSP TVSVNPLTRS PPETSSQLAP NPLLLSPTTE LMEDISESVG 600
    KNQFTSESTH LNIGHRSVGH SMNIECKGID KELTDSKTAH IDIPRISSSL 650
    GKKPSLTSES SIHTITPSVV NFTSLFSNKP FLKLGAVSAS DKHCQVAESL 700
    SSSLQSKPLK KRKGRKARWT KVVARSTCRS PKGLDLERSE LFKSVSCSSL 750
    SNSNSEPAKF MKNIGPSSFV DHDFLKRRLP KLSKSTTPSL ALLTDSEKPS 800
    HKAFATHKLS SSMCVSSDLL SDIYKPKRGR PKAKEMPQLE GPPKRTLKIP 850
    ASKVFSLQSK EEQEPPILQP EIEIPSFKQS LSVSPFPKKR GRPKRQLRSP 900
    VKMKPPVLSV APFVATESPS KLESESDNHR SSSDFFESED QLQDPDDLDD 950
    SHRPAVCSMS DLEMEPDKKI TKRNNGQLMK TIIRKINKMK TLKRKKLLNQ 1000
    ILSSSVESSN KGKVQSKLHN TVSSLAATFG SKLGQQINVS KKGTIYIGKR 1050
    RGRKPKTVLN GILSGSPTSL AVLEQTAQQA AGSALGQILP PLLPSSASSS 1100
    EILPSPVCSQ SSGTSGGQSP VSSDAGFVEP SSVPYLHLHS RQGSMIQTLA 1150
    MKKASKGRRR LSPPTLLPNS PSHLSELTSL KEATPSPISE SHSDETIPSD 1200
    SGIGTDNNST SDRAEKFCGQ KKRRHSFEHV SLIPPETSTV LSSLKEKHKH 1250
    KCKRRNHDYL SYDKMKRQKR KRKKKYPQLR SRQDPDFIAD LEELISRLSE 1300
    IRITHRSHHF IPRDLLPTIF RINFNSFYTH PSFPLDPLHY IRKPDLKKKR 1350
    GRPPKMREAM AEMPFMHSLS FPLSSTGFYP SYGMPYSPSP LTATPLGLGY 1400
    YGRYPPTLYP PPPSPSFTPP LPPPSYMHAG HLLLNPTKYH KKKHKLLRQE 1450
    AFLTTSRTPL LSMSTYPSVP PEMAYGWMVE HKHRHRHKHR EHRSSEQPQV 1500
    SMDAGSSRSV LESLKRYRFG KETVGERYKH KEKHRCHMSC PHLSPSKSLI 1550
    NREEQWVHRE PSESSPLALG LQTPLQIDCS ESSPSLSLGG FTPNSDPASS 1600
    DEHTNLFTSA IVQGSCRVSN PNSSGRKKLT DSPGLFSAQD TSLIRPHRKE 1650
    PLPSSERAVQ TMTGSQPTSD KSSQRPSEST NCSPTRKRSS SESTSSTVNG 1700
    LPSRSPRLLA PGDDSVDSLL QRMVQHEDQE PLEKNLDAVI ASASGPPSSS 1750
    PGHSHSKERA LGKPDSLLVP AAPSDSCSSS ISLLSEKLPS SCSPHHIKRS 1800
    VVEAMQRQAR KMCNYDKILA TKKNLDHVNK ILKAKKLQRQ ARTGNNFVKR 1850
    RPGRPRKCPL QAVVSMQAFQ AARFVSPDAN EGEERAALPL RPDTVTDVIE 1900
    AVVQSVNLSP EHKKGLKRKS WLLEEQTKKK QKPFPEEEQE HPKSFTEAAV 1950
    EIPSPPETPA KPSEPESTLQ PVLSLIPREK KAPRPPKKKY QKAGLYSDVY 2000
    KTTDPKSRLI QLKKEKLEYT PGEHEYGLFP APIHVGKYLR QKRIDFQLPY 2050
    DILWQWKHNQ LYKKPDVPLY KKIRSNVYVD VKPLSGYEAT TCNCKKPEDD 2100
    TGKGCVDDCL NRMIFAECSP NTCPCGEQCC NQRIQRHEWV QCLERFRAEE 2150
    KGWGIRTKEP LKAGQFIIEY LGEVVSEQEF RNRMIEQYHN HSDHYCLNLD 2200
    SGMVIDSYRM GNEARFINHS CDPNCEMQKW SVNGVYRIGL YALKDMPAGT 2250
    ELTYDYNFHS FNVEKQQLCK CGFEKCRGII GGKSQRVNGL ASSKSSQPVA 2300
    THKKSGRSKE KRKSKHKLKK RRGHLSEEPS ENINTPTRLT PQLQMKPMSN 2350
    RERNFVLKHH VFLVRNWEKI RQKQEEVKHT SDNLHSASLY TRWNGICRDD 2400
    GNIKSDVFMT QFSALQTARS VRTRRLAAAE ENIEVARAAR LAQIFKEICD 2450
    GIISYKDSSR QALAAPLLNL PPKKKNADYY EKISEPLDLA TIERQILTGH 2500
    YKTVEAFDAD MLKVFRNAEK YYGRKSPIGR DVCRLRKTYY NARHEASAQI 2550
    DEIVGETASE ADSSETSVSE KENVHEKDDD VIRCVCGLHK DEGLMIQCDK 2600
    CMVWQHCDCM GVNSDVEHYL CEQCDPRPVD REVPMIPRPH YAQPGCVYFI 2650
    CLLRDDLLLR QGDCVYLMRD SRRTPDGHPV RQSYRLLSHI NRDKLDIFRI 2700
    EKLWKNEKEE RFAFGHHYFR PHETHHSPSR RFYHNELFRV PLYEIIPLEA 2750
    VVGTCCVLDL YTYCKGRPKG VKEQDVYICD YRLDKSAHLF YKIHRNRYPV 2800
    CTKPYAFDHF PKKLTPKRDF SPHYVPDNYK RNGGRSSWKS ERPKPPLKDL 2850
    GQEDDALPLI EEVLASQEQA TNELPSLEEP EREVAPVEVS EGEKKAEEGG 2900
    PESQAACTPE ERRHSQRERL NQILLGLLEK IPGKNAIDVT YLLEEGSGRK 2950
    LRRRTLFIPE NSFRK 2965
    Length:2,965
    Mass (Da):331,712
    Last modified:October 31, 2012 - v1
    Checksum:i0EDFB35848AC29FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03005337 Genomic DNA. No translation available.
    RefSeqiXP_537251.2. XM_537251.4.

    Genome annotation databases

    EnsembliENSCAFT00000048670; ENSCAFP00000038677; ENSCAFG00000016944.
    GeneIDi480128.
    KEGGicfa:480128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEX03005337 Genomic DNA. No translation available.
    RefSeqi XP_537251.2. XM_537251.4.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000048670 ; ENSCAFP00000038677 ; ENSCAFG00000016944 .
    GeneIDi 480128.
    KEGGi cfa:480128.

    Organism-specific databases

    CTDi 55870.

    Phylogenomic databases

    GeneTreei ENSGT00740000114921.
    KOi K06101.
    OrthoDBi EOG7ZPNJ4.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR017956. AT_hook_DNA-bd_motif.
    IPR006560. AWS.
    IPR001025. BAH_dom.
    IPR001487. Bromodomain.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01426. BAH. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00384. AT_hook. 3 hits.
    SM00570. AWS. 1 hit.
    SM00439. BAH. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00249. PHD. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51215. AWS. 1 hit.
    PS51038. BAH. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence, comparative analysis and haplotype structure of the domestic dog."
      Broad Sequencing Platform
      Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., Smith D.R.
      , deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.
      Nature 438:803-819(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BoxerImported.
    2. Ensembl
      Submitted (SEP-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: BoxerImported.

    Entry informationi

    Entry nameiJ9NZF7_CANFA
    AccessioniPrimary (citable) accession number: J9NZF7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2012
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3