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Protein
Submitted name:

Integrin subunit alpha 6

Gene

ITGA6

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CFA-2022090. Assembly of collagen fibrils and other multimeric structures.
R-CFA-210991. Basigin interactions.
R-CFA-216083. Integrin cell surface interactions.
R-CFA-3000157. Laminin interactions.
R-CFA-446107. Type I hemidesmosome assembly.

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin subunit alpha 6Imported
Gene namesi
Name:ITGA6Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1013 – 1037HelicalUniRule annotationAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_500142514224 – 1073UniRule annotationAdd BLAST1050

Proteomic databases

PaxDbiJ9NVU0.

Expressioni

Gene expression databases

BgeeiENSCAFG00000013006.

Structurei

3D structure databases

ProteinModelPortaliJ9NVU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 95FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati101 – 166FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati176 – 229FG-GAPPROSITE-ProRule annotationAdd BLAST54
Repeati244 – 300FG-GAPPROSITE-ProRule annotationAdd BLAST57
Repeati301 – 363FG-GAPPROSITE-ProRule annotationAdd BLAST63
Repeati364 – 419FG-GAPPROSITE-ProRule annotationAdd BLAST56
Repeati420 – 479FG-GAPPROSITE-ProRule annotationAdd BLAST60
Domaini464 – 939Integrin_alpha2InterPro annotationAdd BLAST476

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPBB. Eukaryota.
ENOG410XVGZ. LUCA.
GeneTreeiENSGT00760000118782.

Family and domain databases

InterProiView protein in InterPro
IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom_sf.
PfamiView protein in Pfam
PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PRINTSiPR01185. INTEGRINA.
SMARTiView protein in SMART
SM00191. Int_alpha. 5 hits.
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiView protein in PROSITE
PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.

Sequencei

Sequence statusi: Complete.

J9NVU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGRLWLL YLSAGLLPRL GAAFNLDTRE DHVIRKAGEP GSLFGFSLAM
60 70 80 90 100
HRQLQPEDRR LLLVGAPRAV ALPLQRANRT GGLYSCDITS PGPCTRIEFD
110 120 130 140 150
NDADPSSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI
160 170 180 190 200
FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF
210 220 230 240 250
HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETDHDESLV
260 270 280 290 300
PVPANSYLGF SLDSGKGIVS KDEITFVSGA PRANHSGAVV LLKRDMKSAH
310 320 330 340 350
LLPEYIFDGE GLASSFGYDV AVADLNKDGW QDIVIGAPQY FDRDGEVGGA
360 370 380 390 400
VYVYINQQGR WNNVKPIRLN GTKDSMFGIA VKNIGDINQD GYPDIAVGAP
410 420 430 440 450
YDDMGKVFIY HGSPNGINTK PTQILEGKSP YFGYSIAGNM DLDRNSYPDV
460 470 480 490 500
AVGSLSDSVT VFRSRPVINI QKTVTITPDT IDLRQKTLCG APSGICLKVK
510 520 530 540 550
ACFEYTAKPT GYNPSISILG TLEAEKERRK SGLSSRVQFR NQGSEPRYTQ
560 570 580 590 600
ELTLNRQKQK ACMEETLWLQ ENIRDKLRPI PITASVEIQE PNTRRRVNSL
610 620 630 640 650
PEILPILNSN EPKTVHRDVH FLKEGCGDDN ICNSNLKLEY KFCTREGSQD
660 670 680 690 700
KFSYLPIQKG VPELVLKDQK DIALEITVTN SPSNPRDPTK DGDDAHEAKL
710 720 730 740 750
VATFPDTLTY SAYRELRAFP EKQLSCVANQ NGSQVDCELG NPFKRNSSVT
760 770 780 790 800
FYLILSTTEV TFDTTDLDIN LKLETTSNQD NLASITATAK VVIELLLSVS
810 820 830 840 850
GVAKPSQVYF GGTVVGEQAM KSEDEVGSLI EYEFRVINLG KPLKNLGTAT
860 870 880 890 900
LNIQWPKEIS NGKWLLYLVK VESKGLEKIA CEPRGEINFL KLKESHNSRR
910 920 930 940 950
KREIAEKQIE DSRKFSLFAE RKYQTLNCST NVRCVNISCP LRGLDSKASV
960 970 980 990 1000
VLRSRLWNST FLEEYSKMNY LDILVRASID VAATAENIKL PNAGTQIRVT
1010 1020 1030 1040 1050
VFPSKTVAQY SGVPWWIILV AILAGILMLA LLVFILWKCG FFKRNKKDHY
1060 1070
DATYHKAEIH AQPSDKERLT SDA
Length:1,073
Mass (Da):119,504
Last modified:October 31, 2012 - v1
Checksum:i1ED7355AAE0AEB3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03017761 Genomic DNA. No translation available.
RefSeqiXP_005640381.1. XM_005640324.2.

Genome annotation databases

EnsembliENSCAFT00000046049; ENSCAFP00000037282; ENSCAFG00000013006.
GeneIDi100856563.

Similar proteinsi

Entry informationi

Entry nameiJ9NVU0_CANLF
AccessioniPrimary (citable) accession number: J9NVU0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported