Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 3 subunit H

Gene

EIF3H

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotation
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-CFA-72649 Translation initiation complex formation
R-CFA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-CFA-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit HUniRule annotation
Short name:
eIF3hUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 3UniRule annotation
eIF-3 gammaUniRule annotation
eIF3 p40 subunitUniRule annotation
Gene namesi
Name:EIF3HUniRule annotationImported
Synonyms:EIF3S3UniRule annotation
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:40274 EIF3H

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208PhosphoserineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

PaxDbiJ9NTR8
PRIDEiJ9NTR8

Expressioni

Gene expression databases

BgeeiENSCAFG00000000816

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.UniRule annotation

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000036553

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 198MPNInterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the eIF-3 subunit H family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1560 Eukaryota
ENOG410XSR9 LUCA
GeneTreeiENSGT00730000111042
InParanoidiJ9NTR8
OMAiKFNRYQQ
OrthoDBiEOG091G0E5O

Family and domain databases

CDDicd08065 MPN_eIF3h, 1 hit
HAMAPiMF_03007 eIF3h, 1 hit
InterProiView protein in InterPro
IPR027524 eIF3h
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
PANTHERiPTHR10410:SF3 PTHR10410:SF3, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

J9NTR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEMELNRTL IRAQRKESIF QTSVQMASRK EGAGSAATSS SSTTGPAGKG
60 70 80 90 100
KGKGGSGDSA VKQVQIDGLV VLKIIKHYQE EGQGTEVVQG VLLGLVVEDR
110 120 130 140 150
LEITNCFPFP QHTEDDADFD EVQYQMEMMR SLRHVNIDHL HVGWYQSTYY
160 170 180 190 200
GSFVTRALLD SQFSYQHAIE ESVVLIYDPI KTAQGSLSLK AYRLTPKLME
210 220 230 240 250
VCKEKDFSPE ALKKGNITFE HMFEEVPIVI KNSHLINVLM WELEKKSAVA
260 270 280 290 300
DKHELLSLAS SNHLGKNLQL LMDRVDEMSQ DIVKYNTYMR NTSKQQQQKH
310 320 330 340 350
QYQQRRQQEN MQRQSRGEPP LPEEDLSKLF KPPQPPARMD SLLIAGQINT
360 370
YCQNIKEFTA QNLGKLFMAQ ALQEYNN
Length:377
Mass (Da):42,849
Last modified:October 31, 2012 - v1
Checksum:i321D8A7CD0B60681
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03008759 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSCAFT00000047451; ENSCAFP00000036553; ENSCAFG00000000816

Similar proteinsi

Entry informationi

Entry nameiJ9NTR8_CANLF
AccessioniPrimary (citable) accession number: J9NTR8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health