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Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104SubstrateUniRule annotation1
Binding sitei109NADPUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Binding sitei159SubstrateUniRule annotation1
Sitei166Critical for catalysisUniRule annotation1
Sitei237Critical for catalysisUniRule annotation1
Metal bindingi277Magnesium or manganeseUniRule annotation1
Binding sitei285NADPUniRule annotation1
Metal bindingi300Magnesium or manganeseUniRule annotation1
Binding sitei353NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 104NADPUniRule annotation3
Nucleotide bindingi335 – 340NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
OrganismiAcyrthosiphon pisum (Pea aphid)Imported
Taxonomic identifieri7029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidiformesAphidoideaAphididaeMacrosiphiniAcyrthosiphon
Proteomesi
  • UP000007819 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi7029.ACYPI008195-PA.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 426Iso_dhInterPro annotationAdd BLAST391

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 127Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
InParanoidiJ9K5R3.
KOiK00031.
OMAiDTQFKFD.
PhylomeDBiJ9K5R3.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J9K5R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKLLGLTA GLAKSTALAR NRNYATASTR ILAKNPIVEM DGDEMTRIMW
60 70 80 90 100
EKIKETLIFP YIKLDCLYYD LGLPNRDATD DQVTIDAAEA TLKYNVGIKC
110 120 130 140 150
ATITPDEARV EEFKLKKMWL SPNGTIRNIL GGTVFREPII CKTIPRLVPG
160 170 180 190 200
WTKPIVIGRH AHGDQYKATD YLVTRPGQLE LVFTDHKGQV EKLKVFDFKS
210 220 230 240 250
PGVAMAMYNL DDSIASFAHS SFQVALLKKW PLYLSTKNTI LKKYDGRFKD
260 270 280 290 300
IFQNIFEENY KSQFEAANIW YEHRLIDDMV AQALKGDGGF VWACKNYDGD
310 320 330 340 350
VMSDIIAQGY GSLGLMTSVL VCPDGKTLES EAAHGTVTRH YRQHQEGKLT
360 370 380 390 400
STNPIASIYA WTRGLKHRAK LDNTPELAKF CDTLEEACVG SVDAGHMTKD
410 420 430 440
LAACIHGLKN VKEGMYLNTN EYLDSVKEHL DIKLKPDTKK LFASIGAV
Length:448
Mass (Da):50,176
Last modified:October 31, 2012 - v1
Checksum:iAA042AA3E7FB24D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02033188 Genomic DNA. No translation available.
RefSeqiXP_001943698.1. XM_001943663.4.
UniGeneiAps.52014.
Aps.91927.

Genome annotation databases

EnsemblMetazoaiACYPI008195-RA; ACYPI008195-PA; ACYPI008195.
GeneIDi100167396.
KEGGiapi:100167396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02033188 Genomic DNA. No translation available.
RefSeqiXP_001943698.1. XM_001943663.4.
UniGeneiAps.52014.
Aps.91927.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7029.ACYPI008195-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiACYPI008195-RA; ACYPI008195-PA; ACYPI008195.
GeneIDi100167396.
KEGGiapi:100167396.

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
InParanoidiJ9K5R3.
KOiK00031.
OMAiDTQFKFD.
PhylomeDBiJ9K5R3.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJ9K5R3_ACYPI
AccessioniPrimary (citable) accession number: J9K5R3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 7, 2016
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.