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J9K5R3 (J9K5R3_ACYPI) Unreviewed, UniProtKB/TrEMBL

Last modified March 6, 2013. Version 5. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108
EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:XM_001952057.1 EnsemblMetazoa ACYPI008195-PA
OrganismAcyrthosiphon pisum (Pea aphid) [Complete proteome] EnsemblMetazoa ACYPI008195-PA
Taxonomic identifier7029 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Paraneoptera › Hemiptera › Sternorrhyncha › Aphidiformes › Aphidoidea › Aphididae › Macrosiphini › Acyrthosiphon

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding102 – 1043NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding335 – 3406NADP By similarity PIRSR PIRSR000108-4
Region121 – 1277Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2771Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding3001Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site1041Substrate By similarity PIRSR PIRSR000108-2
Binding site1091NADP By similarity PIRSR PIRSR000108-4
Binding site1361Substrate By similarity PIRSR PIRSR000108-2
Binding site1591Substrate By similarity PIRSR PIRSR000108-2
Binding site2851NADP By similarity PIRSR PIRSR000108-4
Binding site3531NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1661Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2371Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
J9K5R3 [UniParc].

Last modified October 31, 2012. Version 1.
Checksum: AA042AA3E7FB24D4

FASTA44850,176
        10         20         30         40         50         60 
MAKKLLGLTA GLAKSTALAR NRNYATASTR ILAKNPIVEM DGDEMTRIMW EKIKETLIFP 

        70         80         90        100        110        120 
YIKLDCLYYD LGLPNRDATD DQVTIDAAEA TLKYNVGIKC ATITPDEARV EEFKLKKMWL 

       130        140        150        160        170        180 
SPNGTIRNIL GGTVFREPII CKTIPRLVPG WTKPIVIGRH AHGDQYKATD YLVTRPGQLE 

       190        200        210        220        230        240 
LVFTDHKGQV EKLKVFDFKS PGVAMAMYNL DDSIASFAHS SFQVALLKKW PLYLSTKNTI 

       250        260        270        280        290        300 
LKKYDGRFKD IFQNIFEENY KSQFEAANIW YEHRLIDDMV AQALKGDGGF VWACKNYDGD 

       310        320        330        340        350        360 
VMSDIIAQGY GSLGLMTSVL VCPDGKTLES EAAHGTVTRH YRQHQEGKLT STNPIASIYA 

       370        380        390        400        410        420 
WTRGLKHRAK LDNTPELAKF CDTLEEACVG SVDAGHMTKD LAACIHGLKN VKEGMYLNTN 

       430        440 
EYLDSVKEHL DIKLKPDTKK LFASIGAV

« Hide

References

« Hide 'large scale' references
[1]Jiang H., Abraham K., Ali S., Alsbrooks S.L., Anim B.N., Anosike U.S., Attaway T., Bandaranaike D.P., Battles P.K., Bell S.N., Bell A.V., Beltran B., Bickham C., Bustamante Y., Caleb T., Canada A., Cardenas V., Carter K. expand/collapse author list , Chacko J., Chandrabose M.N., Chavez D., Chavez A., Chen L., Chu H.-S., Claassen K.J., Cockrell R., Collins M., Cooper J.A., Cree A., Curry S.M., Da Y., Dao M.D., Das B., Davila M.-L., Davy-Carroll L., Denson S., Dinh H., Ebong V.E., Edwards J.R., Egan A., El-Daye J., Escobedo L., Fernandez S., Fernando P.R., Flagg N., Forbes L.D., Fowler R.G., Fu Q., Gabisi R.A., Ganer J., Garbino Pronczuk A., Garcia R.M., Garner T., Garrett T.E., Gonzalez D.A., Hamid H., Hawkins E.S., Hirani K., Hogues M.E., Hollins B., Hsiao C.-H., Jabil R., James M.L., Jhangiani S.N., Johnson B., Johnson Q., Joshi V., Kalu J.B., Kam C., Kashfia A., Keebler J., Kisamo H., Kovar C.L., Lago L.A., Lai C.-Y., Laidlaw J., Lara F., Le T.-K., Lee S.L., Legall F.H., Lemon S.J., Lewis L.R., Li B., Liu Y., Liu Y.-S., Lopez J., Lozado R.J., Lu J., Madu R.C., Maheshwari M., Maheshwari R., Malloy K., Martinez E., Mathew T., Mercado I.C., Mercado C., Meyer B., Montgomery K., Morgan M.B., Munidasa M., Nazareth L.V., Nelson J., Ng B.M., Nguyen N.B., Nguyen P.Q., Nguyen T., Obregon M., Okwuonu G.O., Onwere C.G., Orozco G., Parra A., Patel S., Patil S., Perez A., Perez Y., Pham C., Primus E.L., Pu L.-L., Puazo M., Qin X., Quiroz J.B., Reese J., Richards S., Rives C.M., Robberts R., Ruiz S.J., Ruiz M.J., Santibanez J., Schneider B.W., Sisson I., Smith M., Sodergren E., Song X.-Z., Song B.B., Summersgill H., Thelus R., Thornton R.D., Trejos Z.Y., Usmani K., Vattathil S., Villasana D., Walker D.L., Wang S., Wang K., White C.S., Williams A.C., Williamson J., Wilson K., Woghiren I.O., Woodworth J.R., Worley K.C., Wright R.A., Wu W., Young L., Zhang L., Zhang J., Zhu Y., Muzny D.M., Weinstock G., Gibbs R.A.
Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]EnsemblMetazoa
Submitted (SEP-2012) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

RefSeqXP_001943698.1. XM_001943663.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaACYPI008195-RA; ACYPI008195-PA; ACYPI008195.
GeneID100167396.
KEGGapi:100167396.

Phylogenomic databases

KOK00031.
OMAQYKATDY.
PhylomeDBJ9K5R3.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJ9K5R3_ACYPI
AccessionPrimary (citable) accession number: J9K5R3
Entry history
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: March 6, 2013
This is version 5 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info