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J9K5R3

- J9K5R3_ACYPI

UniProt

J9K5R3 - J9K5R3_ACYPI

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Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041SubstrateUniRule annotation
Binding sitei109 – 1091NADPUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Binding sitei159 – 1591SubstrateUniRule annotation
Sitei237 – 2371Critical for catalysisUniRule annotation
Metal bindingi277 – 2771Magnesium or manganeseUniRule annotation
Binding sitei285 – 2851NADPUniRule annotation
Metal bindingi300 – 3001Magnesium or manganeseUniRule annotation
Binding sitei353 – 3531NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1043NADPUniRule annotation
Nucleotide bindingi335 – 3406NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
OrganismiAcyrthosiphon pisum (Pea aphid)Imported
Taxonomic identifieri7029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidiformesAphidoideaAphididaeMacrosiphiniAcyrthosiphon
ProteomesiUP000007819: Unplaced

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni121 – 1277Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiJ9K5R3.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG7QNVKS.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J9K5R3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKKLLGLTA GLAKSTALAR NRNYATASTR ILAKNPIVEM DGDEMTRIMW
60 70 80 90 100
EKIKETLIFP YIKLDCLYYD LGLPNRDATD DQVTIDAAEA TLKYNVGIKC
110 120 130 140 150
ATITPDEARV EEFKLKKMWL SPNGTIRNIL GGTVFREPII CKTIPRLVPG
160 170 180 190 200
WTKPIVIGRH AHGDQYKATD YLVTRPGQLE LVFTDHKGQV EKLKVFDFKS
210 220 230 240 250
PGVAMAMYNL DDSIASFAHS SFQVALLKKW PLYLSTKNTI LKKYDGRFKD
260 270 280 290 300
IFQNIFEENY KSQFEAANIW YEHRLIDDMV AQALKGDGGF VWACKNYDGD
310 320 330 340 350
VMSDIIAQGY GSLGLMTSVL VCPDGKTLES EAAHGTVTRH YRQHQEGKLT
360 370 380 390 400
STNPIASIYA WTRGLKHRAK LDNTPELAKF CDTLEEACVG SVDAGHMTKD
410 420 430 440
LAACIHGLKN VKEGMYLNTN EYLDSVKEHL DIKLKPDTKK LFASIGAV
Length:448
Mass (Da):50,176
Last modified:October 31, 2012 - v1
Checksum:iAA042AA3E7FB24D4
GO

Sequence databases

RefSeqiXP_001943698.1. XM_001943663.3.
UniGeneiAps.91927.

Genome annotation databases

EnsemblMetazoaiACYPI008195-RA; ACYPI008195-PA; ACYPI008195.
GeneIDi100167396.
KEGGiapi:100167396.

Cross-referencesi

Sequence databases

RefSeqi XP_001943698.1. XM_001943663.3.
UniGenei Aps.91927.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ACYPI008195-RA ; ACYPI008195-PA ; ACYPI008195 .
GeneIDi 100167396.
KEGGi api:100167396.

Phylogenomic databases

InParanoidi J9K5R3.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG7QNVKS.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Jiang H., Abraham K., Ali S., Alsbrooks S.L., Anim B.N., Anosike U.S., Attaway T., Bandaranaike D.P., Battles P.K., Bell S.N., Bell A.V., Beltran B., Bickham C., Bustamante Y., Caleb T., Canada A., Cardenas V., Carter K.
    , Chacko J., Chandrabose M.N., Chavez D., Chavez A., Chen L., Chu H.-S., Claassen K.J., Cockrell R., Collins M., Cooper J.A., Cree A., Curry S.M., Da Y., Dao M.D., Das B., Davila M.-L., Davy-Carroll L., Denson S., Dinh H., Ebong V.E., Edwards J.R., Egan A., El-Daye J., Escobedo L., Fernandez S., Fernando P.R., Flagg N., Forbes L.D., Fowler R.G., Fu Q., Gabisi R.A., Ganer J., Garbino Pronczuk A., Garcia R.M., Garner T., Garrett T.E., Gonzalez D.A., Hamid H., Hawkins E.S., Hirani K., Hogues M.E., Hollins B., Hsiao C.-H., Jabil R., James M.L., Jhangiani S.N., Johnson B., Johnson Q., Joshi V., Kalu J.B., Kam C., Kashfia A., Keebler J., Kisamo H., Kovar C.L., Lago L.A., Lai C.-Y., Laidlaw J., Lara F., Le T.-K., Lee S.L., Legall F.H., Lemon S.J., Lewis L.R., Li B., Liu Y., Liu Y.-S., Lopez J., Lozado R.J., Lu J., Madu R.C., Maheshwari M., Maheshwari R., Malloy K., Martinez E., Mathew T., Mercado I.C., Mercado C., Meyer B., Montgomery K., Morgan M.B., Munidasa M., Nazareth L.V., Nelson J., Ng B.M., Nguyen N.B., Nguyen P.Q., Nguyen T., Obregon M., Okwuonu G.O., Onwere C.G., Orozco G., Parra A., Patel S., Patil S., Perez A., Perez Y., Pham C., Primus E.L., Pu L.-L., Puazo M., Qin X., Quiroz J.B., Reese J., Richards S., Rives C.M., Robberts R., Ruiz S.J., Ruiz M.J., Santibanez J., Schneider B.W., Sisson I., Smith M., Sodergren E., Song X.-Z., Song B.B., Summersgill H., Thelus R., Thornton R.D., Trejos Z.Y., Usmani K., Vattathil S., Villasana D., Walker D.L., Wang S., Wang K., White C.S., Williams A.C., Williamson J., Wilson K., Woghiren I.O., Woodworth J.R., Worley K.C., Wright R.A., Wu W., Young L., Zhang L., Zhang J., Zhu Y., Muzny D.M., Weinstock G., Gibbs R.A.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. EnsemblMetazoa
    Submitted (MAR-2014) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiJ9K5R3_ACYPI
AccessioniPrimary (citable) accession number: J9K5R3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 26, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3