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J9K5R3

- J9K5R3_ACYPI

UniProt

J9K5R3 - J9K5R3_ACYPI

Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041SubstrateUniRule annotation
    Binding sitei109 – 1091NADPUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Binding sitei159 – 1591SubstrateUniRule annotation
    Sitei166 – 1661Critical for catalysis
    Sitei237 – 2371Critical for catalysisUniRule annotation
    Metal bindingi277 – 2771Magnesium or manganeseUniRule annotation
    Binding sitei285 – 2851NADPUniRule annotation
    Metal bindingi300 – 3001Magnesium or manganeseUniRule annotation
    Binding sitei353 – 3531NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi102 – 1043NADPUniRule annotation
    Nucleotide bindingi335 – 3406NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    OrganismiAcyrthosiphon pisum (Pea aphid)Imported
    Taxonomic identifieri7029 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidiformesAphidoideaAphididaeMacrosiphiniAcyrthosiphon
    ProteomesiUP000007819: Unplaced

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni121 – 1277Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiKNTIMKV.
    OrthoDBiEOG7QNVKS.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    J9K5R3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKKLLGLTA GLAKSTALAR NRNYATASTR ILAKNPIVEM DGDEMTRIMW    50
    EKIKETLIFP YIKLDCLYYD LGLPNRDATD DQVTIDAAEA TLKYNVGIKC 100
    ATITPDEARV EEFKLKKMWL SPNGTIRNIL GGTVFREPII CKTIPRLVPG 150
    WTKPIVIGRH AHGDQYKATD YLVTRPGQLE LVFTDHKGQV EKLKVFDFKS 200
    PGVAMAMYNL DDSIASFAHS SFQVALLKKW PLYLSTKNTI LKKYDGRFKD 250
    IFQNIFEENY KSQFEAANIW YEHRLIDDMV AQALKGDGGF VWACKNYDGD 300
    VMSDIIAQGY GSLGLMTSVL VCPDGKTLES EAAHGTVTRH YRQHQEGKLT 350
    STNPIASIYA WTRGLKHRAK LDNTPELAKF CDTLEEACVG SVDAGHMTKD 400
    LAACIHGLKN VKEGMYLNTN EYLDSVKEHL DIKLKPDTKK LFASIGAV 448
    Length:448
    Mass (Da):50,176
    Last modified:October 31, 2012 - v1
    Checksum:iAA042AA3E7FB24D4
    GO

    Sequence databases

    RefSeqiXP_001943698.1. XM_001943663.3.

    Genome annotation databases

    EnsemblMetazoaiACYPI008195-RA; ACYPI008195-PA; ACYPI008195.
    GeneIDi100167396.
    KEGGiapi:100167396.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_001943698.1. XM_001943663.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ACYPI008195-RA ; ACYPI008195-PA ; ACYPI008195 .
    GeneIDi 100167396.
    KEGGi api:100167396.

    Phylogenomic databases

    KOi K00031.
    OMAi KNTIMKV.
    OrthoDBi EOG7QNVKS.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jiang H., Abraham K., Ali S., Alsbrooks S.L., Anim B.N., Anosike U.S., Attaway T., Bandaranaike D.P., Battles P.K., Bell S.N., Bell A.V., Beltran B., Bickham C., Bustamante Y., Caleb T., Canada A., Cardenas V., Carter K.
      , Chacko J., Chandrabose M.N., Chavez D., Chavez A., Chen L., Chu H.-S., Claassen K.J., Cockrell R., Collins M., Cooper J.A., Cree A., Curry S.M., Da Y., Dao M.D., Das B., Davila M.-L., Davy-Carroll L., Denson S., Dinh H., Ebong V.E., Edwards J.R., Egan A., El-Daye J., Escobedo L., Fernandez S., Fernando P.R., Flagg N., Forbes L.D., Fowler R.G., Fu Q., Gabisi R.A., Ganer J., Garbino Pronczuk A., Garcia R.M., Garner T., Garrett T.E., Gonzalez D.A., Hamid H., Hawkins E.S., Hirani K., Hogues M.E., Hollins B., Hsiao C.-H., Jabil R., James M.L., Jhangiani S.N., Johnson B., Johnson Q., Joshi V., Kalu J.B., Kam C., Kashfia A., Keebler J., Kisamo H., Kovar C.L., Lago L.A., Lai C.-Y., Laidlaw J., Lara F., Le T.-K., Lee S.L., Legall F.H., Lemon S.J., Lewis L.R., Li B., Liu Y., Liu Y.-S., Lopez J., Lozado R.J., Lu J., Madu R.C., Maheshwari M., Maheshwari R., Malloy K., Martinez E., Mathew T., Mercado I.C., Mercado C., Meyer B., Montgomery K., Morgan M.B., Munidasa M., Nazareth L.V., Nelson J., Ng B.M., Nguyen N.B., Nguyen P.Q., Nguyen T., Obregon M., Okwuonu G.O., Onwere C.G., Orozco G., Parra A., Patel S., Patil S., Perez A., Perez Y., Pham C., Primus E.L., Pu L.-L., Puazo M., Qin X., Quiroz J.B., Reese J., Richards S., Rives C.M., Robberts R., Ruiz S.J., Ruiz M.J., Santibanez J., Schneider B.W., Sisson I., Smith M., Sodergren E., Song X.-Z., Song B.B., Summersgill H., Thelus R., Thornton R.D., Trejos Z.Y., Usmani K., Vattathil S., Villasana D., Walker D.L., Wang S., Wang K., White C.S., Williams A.C., Williamson J., Wilson K., Woghiren I.O., Woodworth J.R., Worley K.C., Wright R.A., Wu W., Young L., Zhang L., Zhang J., Zhu Y., Muzny D.M., Weinstock G., Gibbs R.A.
      Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. EnsemblMetazoa
      Submitted (MAR-2014) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiJ9K5R3_ACYPI
    AccessioniPrimary (citable) accession number: J9K5R3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2012
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3