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Protein
Submitted name:

Nuclear factor erythroid 2-related factor 1

Gene

NFE2L1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor erythroid 2-related factor 1Imported
Gene namesi
Name:NFE2L1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7781. NFE2L1.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiJ9JIE5.

Expressioni

Gene expression databases

ExpressionAtlasiJ9JIE5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354855.

Structurei

3D structure databases

ProteinModelPortaliJ9JIE5.
SMRiJ9JIE5. Positions 601-669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini643 – 70664BZIP (basic-leucine zipper)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili661 – 70242Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3863. Eukaryota.
ENOG410ZGMS. LUCA.
GeneTreeiENSGT00830000128250.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR029847. Nrf1.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR24411:SF31. PTHR24411:SF31. 3 hits.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J9JIE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY
60 70 80 90 100
TQTQFHNLRN TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV
110 120 130 140 150
NAWLVHRDPE GSVSGSQPNS GLALESSSGL QDVTGPDNGV RESETEQGFG
160 170 180 190 200
EDLEDLGAVA PPVSGDLTKE DIDLGAGREV FDYSHRQKEQ DVEKELRDGG
210 220 230 240 250
EQDTWAGEGA EALARNLLVD GETGESFPAQ VPSGEDQTAL SLEECLRLLE
260 270 280 290 300
ATCPFGENAE FPADISSITE AVPSESEPPA LQNNLLSPLL TGTESPFDLE
310 320 330 340 350
QQWQDLMSIM EMQAMEVNTS ASEILYSAPP GDPLSTNYSL APNTPINQNV
360 370 380 390 400
SLHQASLGGC SQDFLLFSPE VESLPVASSS TLLPLAPSNS TSLNSTFGST
410 420 430 440 450
NLTGLFFPPQ LNGTANDTAG PELPDPLGGL LDEAMLDEIS LMDLAIEEGF
460 470 480 490 500
NPVQASQLEE EFDSDSGLSL DSSHSPSSLS SSEGSSSSSS SSSSSSSSAS
510 520 530 540 550
SSASSSFSEE GAVGYSSDSE TLDLEEAEGA VGYQPEYSKF CRMSYQDPAQ
560 570 580 590 600
LSCLPYLEHV GHNHTYNMAP SALDSADLPP PSALKKGSKE KQADFLDKQM
610 620 630 640 650
SRDEHRARAM KIPFTNDKII NLPVEEFNEL LSKYQLSEAQ LSLIRDIRRR
660 670 680 690 700
GKNKMAAQNC RKRKLDTILN LERDVEDLQR DKARLLREKV EFLRSLRQMK
710 720 730 740 750
QKVQSLYQEV FGRLRDENGR PYSPSQYALQ YAGDGSVLLI PRTMADQQAR
760
RQERKPKDRR K
Length:761
Mass (Da):83,322
Last modified:October 31, 2012 - v1
Checksum:i5F9483EA9CD012E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004477 Genomic DNA. No translation available.
RefSeqiXP_005257468.1. XM_005257411.2.
UniGeneiHs.514284.

Genome annotation databases

EnsembliENST00000361665; ENSP00000355190; ENSG00000082641.
GeneIDi4779.
UCSCiuc002inc.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004477 Genomic DNA. No translation available.
RefSeqiXP_005257468.1. XM_005257411.2.
UniGeneiHs.514284.

3D structure databases

ProteinModelPortaliJ9JIE5.
SMRiJ9JIE5. Positions 601-669.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354855.

Proteomic databases

PaxDbiJ9JIE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361665; ENSP00000355190; ENSG00000082641.
GeneIDi4779.
UCSCiuc002inc.2. human.

Organism-specific databases

CTDi4779.
HGNCiHGNC:7781. NFE2L1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3863. Eukaryota.
ENOG410ZGMS. LUCA.
GeneTreeiENSGT00830000128250.

Miscellaneous databases

ChiTaRSiNFE2L1. human.
GenomeRNAii4779.

Gene expression databases

ExpressionAtlasiJ9JIE5. baseline and differential.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR029847. Nrf1.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR24411:SF31. PTHR24411:SF31. 3 hits.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (SEP-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiJ9JIE5_HUMAN
AccessioniPrimary (citable) accession number: J9JIE5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: May 11, 2016
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.