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Protein
Submitted name:

Hexokinase domain containing 1

Gene

HKDC1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseSAAS annotation, Transferase
Biological processGlycolysisSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Hexokinase domain containing 1Imported
Gene namesi
Name:HKDC1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiJ9JHN0.
PRIDEiJ9JHN0.

Expressioni

Gene expression databases

BgeeiENSCAFG00000032754.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035961.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 219Hexokinase_1InterPro annotationAdd BLAST198
Domaini225 – 459Hexokinase_2InterPro annotationAdd BLAST235
Domaini470 – 665Hexokinase_1InterPro annotationAdd BLAST196
Domaini672 – 906Hexokinase_2InterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the hexokinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.
InParanoidiJ9JHN0.
KOiK00844.
OMAiKIETRHV.
OrthoDBiEOG091G08MD.
TreeFamiTF314238.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
PROSITEiView protein in PROSITE
PS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 2 hits.

Sequencei

Sequence statusi: Complete.

J9JHN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAIHLMAFY FSKLKEDQIK KVDRFLYHMR LSDETLLDIM ARFQAEMQKG
60 70 80 90 100
LGKDTNPTAS VKMLPTFVRA IPDGSENGEF LSLDLGGSKF RVLKVQVSEE
110 120 130 140 150
GKRNVQMESQ FYPTPNEIIR GNGSELFDYI ADCLADFMKT RGLKHKKFPL
160 170 180 190 200
GLTFSFPCRQ TKLEEGILLS WTKKFKARGV QDTDVVSCLT KAVKKHKDID
210 220 230 240 250
VDILTLVNDT VGTMMTCAYD DPYCEVGVII GTGTNACYME DMSNIDLVEG
260 270 280 290 300
DEGRMCINTE WGAFGDDGTL EDIRTEFDRE LDLGSLNPGK QLFEKMISGL
310 320 330 340 350
YLGELVRIIL LKMAKAGLLF GGKKSSALHT KGKIETRHVA AMEKYKEGLA
360 370 380 390 400
NTREILTDLG LEPSEADCIA VQHVCTIVSF RSANLCAAAL AAILTRLREN
410 420 430 440 450
KKLERLRTTV GMDGTLYKIH PQYPKRLHKV VRRLVPNCDV RFLLSESGST
460 470 480 490 500
KGAAMVTAVA SRVQAQRKQI DKVLALFQLT REQLMDVQGK MRREFEYGLK
510 520 530 540 550
RDTHLMATVK MLPTYVCGMP DGTEKGKFLA LDLGGTNFRV LLVKIRSGRR
560 570 580 590 600
SVRMYNKIFA IPLEIMQGTG EELFDHIVQC IADFLDYMGL KGVQLPLGFT
610 620 630 640 650
FSFPCRQTSI DKGTLIEWTK GFKATDCEGE DVVDMLREAI KRRNEFDLDI
660 670 680 690 700
VAVVNDTVGT MMTCGHEDPN CEIGLIAGTG SNMCYMEEMR NIELVEGDEG
710 720 730 740 750
KMCINTEWGG FGDNGCIDDI RTQYDEKVDE GSLNPGKQRY EKMTSGMYLG
760 770 780 790 800
EIVRQILIDL TKQGLLFRGQ ISERLRTRGI FETKFLSQIE SDRLALLQVR
810 820 830 840 850
SILQQLGLDS TCEDSIVVKE VCGAVSRRAA QLYGAGLAAV VEKKREDQGL
860 870 880 890 900
EYLKITVGVD GTLYKLHPHF SRILQETVKE LAPRCDVTLM LSEDGSGKGA
910
ALITAVAKRL QQAQKEN
Length:917
Mass (Da):102,652
Last modified:October 31, 2012 - v1
Checksum:i89B888DF7AFF3436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03002786 Genomic DNA. No translation available.
RefSeqiXP_546137.2. XM_546137.4.

Genome annotation databases

EnsembliENSCAFT00000046047; ENSCAFP00000035961; ENSCAFG00000032754.
GeneIDi489019.
KEGGicfa:489019.

Similar proteinsi

Entry informationi

Entry nameiJ9JHN0_CANLF
AccessioniPrimary (citable) accession number: J9JHN0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: August 30, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported