ID J9HT37_AEDAE Unreviewed; 461 AA. AC J9HT37; DT 31-OCT-2012, integrated into UniProtKB/TrEMBL. DT 31-OCT-2012, sequence version 1. DT 24-JAN-2024, entry version 70. DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007}; DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007}; GN Name=5571932 {ECO:0000313|EnsemblMetazoa:AAEL009387-PB}; OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; OC Culicinae; Aedini; Aedes; Stegomyia. OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL009387-PB, ECO:0000313|Proteomes:UP000008820}; RN [1] {ECO:0000313|EnsemblMetazoa:AAEL009387-PB, ECO:0000313|Proteomes:UP000008820} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL009387-PB, RC ECO:0000313|Proteomes:UP000008820}; RG Aedes aegypti Genome Working Group (AGWG); RA Matthews B.J.; RT "Aedes aegypti genome working group (AGWG) sequencing and assembly."; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EnsemblMetazoa:AAEL009387-PB} RP IDENTIFICATION. RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL009387-PB}; RG EnsemblMetazoa; RL Submitted (MAY-2020) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+); CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1; CC Evidence={ECO:0000256|ARBA:ARBA00001397}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126; CC Evidence={ECO:0000256|ARBA:ARBA00001397}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+); CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1; CC Evidence={ECO:0000256|ARBA:ARBA00000435}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826; CC Evidence={ECO:0000256|ARBA:ARBA00000435}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+); CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1; CC Evidence={ECO:0000256|ARBA:ARBA00000417}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741; CC Evidence={ECO:0000256|ARBA:ARBA00000417}; CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 1/4. CC {ECO:0000256|ARBA:ARBA00004888}. CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism. CC {ECO:0000256|ARBA:ARBA00005028}. CC -!- SIMILARITY: Belongs to the hexokinase family. CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_011493158.1; XM_011494856.1. DR AlphaFoldDB; J9HT37; -. DR STRING; 7159.J9HT37; -. DR PaxDb; 7159-AAEL009387-PB; -. DR EnsemblMetazoa; AAEL009387-RB; AAEL009387-PB; AAEL009387. DR GeneID; 5571932; -. DR VEuPathDB; VectorBase:AAEL009387; -. DR eggNOG; KOG1369; Eukaryota. DR OMA; ADCVQQF; -. DR OrthoDB; 5481886at2759; -. DR UniPathway; UPA00109; UER00180. DR UniPathway; UPA00242; -. DR Proteomes; UP000008820; Chromosome 3. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0005536; F:glucose binding; IEA:InterPro. DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway. DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway. DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro. DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1. DR Gene3D; 3.30.420.40; -; 1. DR Gene3D; 3.40.367.20; -; 1. DR InterPro; IPR043129; ATPase_NBD. DR InterPro; IPR001312; Hexokinase. DR InterPro; IPR019807; Hexokinase_BS. DR InterPro; IPR022673; Hexokinase_C. DR InterPro; IPR022672; Hexokinase_N. DR PANTHER; PTHR19443; HEXOKINASE; 1. DR PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1. DR Pfam; PF00349; Hexokinase_1; 1. DR Pfam; PF03727; Hexokinase_2; 1. DR PRINTS; PR00475; HEXOKINASE. DR SUPFAM; SSF53067; Actin-like ATPase domain; 2. DR PROSITE; PS00378; HEXOKINASE_1; 1. DR PROSITE; PS51748; HEXOKINASE_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007}; KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU362007}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU362007}; KW Reference proteome {ECO:0000313|Proteomes:UP000008820}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}. FT DOMAIN 19..214 FT /note="Hexokinase N-terminal" FT /evidence="ECO:0000259|Pfam:PF00349" FT DOMAIN 220..455 FT /note="Hexokinase C-terminal" FT /evidence="ECO:0000259|Pfam:PF03727" SQ SEQUENCE 461 AA; 51552 MW; F2ECF87D9F34F858 CRC64; MDLVKPFMDL HVDRVSKEIR EQCQELILSD KQIEEIMRRL LKEINRGLGK ATQPEADIKC FITYVQDLPN GKEKGKFLAL DLGGTNFRVL LIHLKDENDF EMLSKIYAIP QSIMLGSGTQ LFDHIAECLA NFMKEHSVYE EKLPLGFTFS FPLTQLGLTK GILARWTKGF NCSGVVGEDV VQLLKDAIAR RGDVQIEICA ILNDTTGTLM SCAWKNHNCR IGLIVGTGSN ACYVEKVENC EMFDGPKDPK KEHVLINTEW GAFGDNGALD FVRTEYDREI DHFSINPGRQ IQEKMISGMY MGELARLAIV KFTRAGLLFG GVGSDILFKR GQFFTKYVSE IESDKPGTYM YCRDVLDELG LEHATDEDCA NVRYICECVS SRAAHLVSAG IAALINKMDE KSVTVGVDGS VYRFHPKFHD LMKAKIRQFV KPDISFDLML SEDGSGRGAA LVAAVACREA H //