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J7QH41

- J7QH41_BORP1

UniProt

J7QH41 - J7QH41_BORP1

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Protein
Kynureninase
Gene
kynU, BN118_3515
Organism
Bordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei98 – 981Pyridoxal phosphate By similarityUniRule annotation
Binding sitei201 – 2011Pyridoxal phosphate By similarityUniRule annotation
Binding sitei204 – 2041Pyridoxal phosphate By similarityUniRule annotation
Binding sitei226 – 2261Pyridoxal phosphate By similarityUniRule annotation
Binding sitei256 – 2561Pyridoxal phosphate By similarityUniRule annotation
Binding sitei282 – 2821Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:BN118_3515Imported
OrganismiBordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323)Imported
Taxonomic identifieri568706 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000005250: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliJ7QH41.
SMRiJ7QH41. Positions 2-404.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1324Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

J7QH41-1 [UniParc]FASTAAdd to Basket

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MTTRQACLEA DRRDPLAAFK DEFELPAGLI YLDGNSLGAL PRGAAARAAQ    50
VIGQEWGQGL IRSWNTAGWF ELPARLGNKL AGLIGAGQDE VVMTDSTSLN 100
IFKALAAALR LAQRAAPQRK VIVSERDNFP TDLYMIQGMI DLLRQGYELR 150
LVDAGLSLEQ ALDDDVAVVL LSHVNYRTGA MHDMAAVSRR AHARGALIIW 200
DLAHAAGAVP VALDADGADF AVGCTYKYLN GGPGSPAFIW VAPRHRDDFW 250
QPLSGWWGHR QPFEMADTYV PAQGIRRYLC GTQPIVSLAT AECGLDIALR 300
ADIAQVRAKS LALGDRFIAL VESRCADHPL TLATPREHAR RGSHVSFLHP 350
QGYAVMQALI ARGVIGDYRE PELLRFGLTP LYLSHADIWD AVEILREVLD 400
TRAWDRPQYR ERAAVT 416
Length:416
Mass (Da):45,694
Last modified:October 31, 2012 - v1
Checksum:i7DCA08DCDD5AA37B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE965805 Genomic DNA. Translation: CCJ64940.1.
RefSeqiYP_006627955.1. NC_018518.1.

Genome annotation databases

EnsemblBacteriaiCCJ64940; CCJ64940; BN118_3515.
GeneIDi13803207.
KEGGibper:BN118_3515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE965805 Genomic DNA. Translation: CCJ64940.1 .
RefSeqi YP_006627955.1. NC_018518.1.

3D structure databases

ProteinModelPortali J7QH41.
SMRi J7QH41. Positions 2-404.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCJ64940 ; CCJ64940 ; BN118_3515 .
GeneIDi 13803207.
KEGGi bper:BN118_3515.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens."
    Park J., Zhang Y., Buboltz A.M., Zhang X., Schuster S.C., Ahuja U., Liu M., Miller J.F., Sebaihia M., Bentley S.D., Parkhill J., Harvill E.T.
    BMC Genomics 13:545-545(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9797 / DSM 5571 / NCTC 10739 / 18323.

Entry informationi

Entry nameiJ7QH41_BORP1
AccessioniPrimary (citable) accession number: J7QH41
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: July 9, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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