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J7QH41

- J7QH41_BORP1

UniProt

J7QH41 - J7QH41_BORP1

Protein

Kynureninase

Gene

kynU

Organism
Bordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei97 – 971Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei98 – 981Pyridoxal phosphateUniRule annotation
    Binding sitei201 – 2011Pyridoxal phosphateUniRule annotation
    Binding sitei204 – 2041Pyridoxal phosphateUniRule annotation
    Binding sitei226 – 2261Pyridoxal phosphateUniRule annotation
    Binding sitei256 – 2561Pyridoxal phosphateUniRule annotation
    Binding sitei282 – 2821Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:BN118_3515Imported
    OrganismiBordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323)Imported
    Taxonomic identifieri568706 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000005250: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei227 – 2271N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliJ7QH41.
    SMRiJ7QH41. Positions 2-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1324Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    J7QH41-1 [UniParc]FASTAAdd to Basket

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    MTTRQACLEA DRRDPLAAFK DEFELPAGLI YLDGNSLGAL PRGAAARAAQ    50
    VIGQEWGQGL IRSWNTAGWF ELPARLGNKL AGLIGAGQDE VVMTDSTSLN 100
    IFKALAAALR LAQRAAPQRK VIVSERDNFP TDLYMIQGMI DLLRQGYELR 150
    LVDAGLSLEQ ALDDDVAVVL LSHVNYRTGA MHDMAAVSRR AHARGALIIW 200
    DLAHAAGAVP VALDADGADF AVGCTYKYLN GGPGSPAFIW VAPRHRDDFW 250
    QPLSGWWGHR QPFEMADTYV PAQGIRRYLC GTQPIVSLAT AECGLDIALR 300
    ADIAQVRAKS LALGDRFIAL VESRCADHPL TLATPREHAR RGSHVSFLHP 350
    QGYAVMQALI ARGVIGDYRE PELLRFGLTP LYLSHADIWD AVEILREVLD 400
    TRAWDRPQYR ERAAVT 416
    Length:416
    Mass (Da):45,694
    Last modified:October 31, 2012 - v1
    Checksum:i7DCA08DCDD5AA37B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE965805 Genomic DNA. Translation: CCJ64940.1.
    RefSeqiYP_006627955.1. NC_018518.1.

    Genome annotation databases

    EnsemblBacteriaiCCJ64940; CCJ64940; BN118_3515.
    GeneIDi13803207.
    KEGGibper:BN118_3515.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE965805 Genomic DNA. Translation: CCJ64940.1 .
    RefSeqi YP_006627955.1. NC_018518.1.

    3D structure databases

    ProteinModelPortali J7QH41.
    SMRi J7QH41. Positions 2-404.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCJ64940 ; CCJ64940 ; BN118_3515 .
    GeneIDi 13803207.
    KEGGi bper:BN118_3515.

    Phylogenomic databases

    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens."
      Park J., Zhang Y., Buboltz A.M., Zhang X., Schuster S.C., Ahuja U., Liu M., Miller J.F., Sebaihia M., Bentley S.D., Parkhill J., Harvill E.T.
      BMC Genomics 13:545-545(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 9797 / DSM 5571 / NCTC 10739 / 18323Imported.

    Entry informationi

    Entry nameiJ7QH41_BORP1
    AccessioniPrimary (citable) accession number: J7QH41
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2012
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3