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J7QFI5 (J7QFI5_METSZ) Unreviewed, UniProtKB/TrEMBL

Last modified December 11, 2013. Version 8. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:BN69_0895 EMBL CCJ06346.1
OrganismMethylocystis sp. (strain SC2) [Complete proteome] [HAMAP] EMBL CCJ06346.1
Taxonomic identifier187303 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylocystaceaeMethylocystis

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding308 – 3136NADP By similarity
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
J7QFI5 [UniParc].

Last modified October 31, 2012. Version 1.
Checksum: E28F4A135E81B681

FASTA40345,252
        10         20         30         40         50         60 
MRKIKVASPV VELDGDEMTR IIWAAIKEKL IRPYLDVDLL YYDLSIQNRD ATNDQVTIDA 

        70         80         90        100        110        120 
AYAIKKHGVG VKCATITPDE ARVKEFNLKE MWKSPNGTIR NILGGVIFRE PIICRNVPRL 

       130        140        150        160        170        180 
VPGWTQPIIV GRHAFGDQYK ATDFKVPGKG RLTIKFEGVD GDVIEKEVFN FPGAGVALAM 

       190        200        210        220        230        240 
YNLDESISEF ARATFNYGLT RRYPVYLSTK NTILKAYDGR FKDLFQEIYD AEFKSKFEAL 

       250        260        270        280        290        300 
GLTYEHRLID DMVASALKWS GGYIWACKNY DGDVQSDTVA QGFGSLGLMT SVLMTPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYREHQKG HETSTNSIAS IFAWTRALAH RGKLDGNDEL TRFARTLEDV 

       370        380        390        400 
CVATVESGFM TKDLALLVGC NQKWLSTTGF LDKIDENLRR AME 

« Hide

References

[1]"Complete genome sequence of Methylocystis sp. strain SC2, an aerobic methanotroph with high-affinity methane oxidation potential."
Dam B., Dam S., Kube M., Reinhardt R., Liesack W.
J. Bacteriol. 194:6008-6009(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC2 EMBL CCJ06346.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE956757 Genomic DNA. Translation: CCJ06346.1.
RefSeqYP_006590997.1. NC_018485.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCJ06346; CCJ06346; BN69_0895.
GeneID13519097.
KEGGmsc:BN69_0895.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJ7QFI5_METSZ
AccessionPrimary (citable) accession number: J7QFI5
Entry history
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: December 11, 2013
This is version 8 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)