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J7QFI5

- J7QFI5_METSZ

UniProt

J7QFI5 - J7QFI5_METSZ

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Protein

Isocitrate dehydrogenase [NADP]

Gene
BN69_0895
Organism
Methylocystis sp. (strain SC2)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarity
Binding sitei258 – 2581NADP By similarityUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese By similarity
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi308 – 3136NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:BN69_0895Imported
OrganismiMethylocystis sp. (strain SC2)Imported
Taxonomic identifieri187303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylocystaceaeMethylocystis
ProteomesiUP000005263: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J7QFI5-1 [UniParc]FASTAAdd to Basket

« Hide

MRKIKVASPV VELDGDEMTR IIWAAIKEKL IRPYLDVDLL YYDLSIQNRD    50
ATNDQVTIDA AYAIKKHGVG VKCATITPDE ARVKEFNLKE MWKSPNGTIR 100
NILGGVIFRE PIICRNVPRL VPGWTQPIIV GRHAFGDQYK ATDFKVPGKG 150
RLTIKFEGVD GDVIEKEVFN FPGAGVALAM YNLDESISEF ARATFNYGLT 200
RRYPVYLSTK NTILKAYDGR FKDLFQEIYD AEFKSKFEAL GLTYEHRLID 250
DMVASALKWS GGYIWACKNY DGDVQSDTVA QGFGSLGLMT SVLMTPDGKT 300
VEAEAAHGTV TRHYREHQKG HETSTNSIAS IFAWTRALAH RGKLDGNDEL 350
TRFARTLEDV CVATVESGFM TKDLALLVGC NQKWLSTTGF LDKIDENLRR 400
AME 403
Length:403
Mass (Da):45,252
Last modified:October 31, 2012 - v1
Checksum:iE28F4A135E81B681
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE956757 Genomic DNA. Translation: CCJ06346.1.
RefSeqiWP_014890380.1. NC_018485.1.
YP_006590997.1. NC_018485.1.

Genome annotation databases

EnsemblBacteriaiCCJ06346; CCJ06346; BN69_0895.
GeneIDi13519097.
KEGGimsc:BN69_0895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE956757 Genomic DNA. Translation: CCJ06346.1 .
RefSeqi WP_014890380.1. NC_018485.1.
YP_006590997.1. NC_018485.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCJ06346 ; CCJ06346 ; BN69_0895 .
GeneIDi 13519097.
KEGGi msc:BN69_0895.

Phylogenomic databases

KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Methylocystis sp. strain SC2, an aerobic methanotroph with high-affinity methane oxidation potential."
    Dam B., Dam S., Kube M., Reinhardt R., Liesack W.
    J. Bacteriol. 194:6008-6009(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC2Imported.

Entry informationi

Entry nameiJ7QFI5_METSZ
AccessioniPrimary (citable) accession number: J7QFI5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 3, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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