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J7PUI3 (J7PUI3_LISMN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 6. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL CBY72636.1
Synonyms:ddl HAMAP-Rule MF_00047
ORF Names:LMOSLCC2378_0869 EMBL CBY72636.1
OrganismListeria monocytogenes SLCC2378 EMBL CBY72636.1
Taxonomic identifier879088 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria ›

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. SAAS SAAS005905 HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. SAAS SAAS005905 HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905 HAMAP-Rule MF_00047

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS005905 HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity SAAS SAAS005905 HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. SAAS SAAS005905 HAMAP-Rule MF_00047

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain144 – 352209ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding177 – 23256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3061Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3191Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3191Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3211Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
J7PUI3 [UniParc].

Last modified October 31, 2012. Version 1.
Checksum: FC5A5951BA851BDA

FASTA37040,569
        10         20         30         40         50         60 
MKTKLILLYG GKSAEHEVSL QTAFSVINAL DLEKFEAAPI YITNEGEWIQ GPLLSGKLDF 

        70         80         90        100        110        120 
VEQLRFSATD TIKLATTESE KSEGEAISPA VLEADGQETV VFPLLHGPNG EDGTVQGLFE 

       130        140        150        160        170        180 
VLNIPYVGNG VLASSAAMDK IVMKKIFADA GIPQVPAVAV RLIDWKNYQA EMVAEMEEVL 

       190        200        210        220        230        240 
TYPVFVKPAN LGSSVGISKA TNKKELADAM TEAFLYDRRV VVEQGVVARE IEMGVLGNDT 

       250        260        270        280        290        300 
PVCSVPGEIL PEGAVATFYD YKAKYQDNNT ALIIPTEVDP EILEQMKEYA VQAFLGLDAS 

       310        320        330        340        350        360 
GLVRADFFLT EDNQLFLNEV NTMPGFTPYS MYPLLWQETG LPYGALIERL VDLAKERHAA 

       370 
KNALKYKLED

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References

[1]"The genome sequences of 11 strains of Listeria monocytogenes covering all known serotypes."
Kuenne C., Billion A., Pischimarov J., Oehm S., Voget S., Goesmann A., Daniel R., Hain T., Chakraborty T.
Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: SLCC2378 EMBL CBY72636.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FR733644 Genomic DNA. Translation: CBY72636.1.
RefSeqYP_006675538.1. NC_018585.1.

3D structure databases

ProteinModelPortalJ7PUI3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBY72636; CBY72636; LMOSLCC2378_0869.
GeneID13645081.
KEGGlmoo:LMOSLCC2378_0869.

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJ7PUI3_LISMN
AccessionPrimary (citable) accession number: J7PUI3
Entry history
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: April 3, 2013
This is version 6 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info