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J7PMU5

- J7PMU5_LISMN

UniProt

J7PMU5 - J7PMU5_LISMN

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Protein

Alanine racemase

Gene

alr

Organism
Listeria monocytogenes ATCC 19117
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:LMOATCC19117_0905Imported
OrganismiListeria monocytogenes ATCC 19117Imported
Taxonomic identifieri882095 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000004013: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliJ7PMU5.
SMRiJ7PMU5. Positions 4-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J7PMU5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTGWHRPTW IEIDRAAIRE NIKNEQNKLP ENVDLWAVVK ANAYGHGIIE
60 70 80 90 100
VARTAKEAGA KGFCVAILDE ALALREAGFQ DDFILVLGAT RKEDANLAAK
110 120 130 140 150
NHISLTVFRE DWLEDLTLEA PLRIHLKVDS GMGRLGIRTT DEARRIETTI
160 170 180 190 200
AKDNQLQLEG IYTHFATADQ LETSYFEQQL AKFQTILTSL KNRPTYVHTA
210 220 230 240 250
NSAASLLQPQ IGFDAIRFGI SMYGLTPSTE IKTSLPFELK PALALYTEMV
260 270 280 290 300
HVKELAPGDS VSYGATYTAT EREWVATLPI GYADGLIRHY SGFHVLVDGE
310 320 330 340 350
LAPIIGRVCM DQTIIKLPRE FQTGSKVTII GTDHGNTITA DDAAHYLDTI
360
NYEVTCLLNE RIPRKYIH
Length:368
Mass (Da):41,054
Last modified:October 31, 2012 - v1
Checksum:iFA192B48C2D9BC3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR733643 Genomic DNA. Translation: CBY69804.1.
RefSeqiYP_006672706.1. NC_018584.1.

Genome annotation databases

EnsemblBacteriaiCBY69804; CBY69804; LMOATCC19117_0905.
GeneIDi13641217.
KEGGilmoa:LMOATCC19117_0905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR733643 Genomic DNA. Translation: CBY69804.1 .
RefSeqi YP_006672706.1. NC_018584.1.

3D structure databases

ProteinModelPortali J7PMU5.
SMRi J7PMU5. Positions 4-367.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBY69804 ; CBY69804 ; LMOATCC19117_0905 .
GeneIDi 13641217.
KEGGi lmoa:LMOATCC19117_0905.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome."
    Kuenne C., Billion A., Mraheil M.A., Strittmatter A., Daniel R., Goesmann A., Barbuddhe S., Hain T., Chakraborty T.
    BMC Genomics 14:47-47(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19117Imported.

Entry informationi

Entry nameiJ7PMU5_LISMN
AccessioniPrimary (citable) accession number: J7PMU5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 26, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3