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J7N5W1

- J7N5W1_LISMN

UniProt

J7N5W1 - J7N5W1_LISMN

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Protein

Thymidine kinase

Gene

tdk

Organism
Listeria monocytogenes SLCC2755
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptorUniRule annotation
Metal bindingi143 – 1431ZincUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi85 – 884ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:LMOSLCC2755_2550Imported
OrganismiListeria monocytogenes SLCC2755Imported
Taxonomic identifieri932919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000004009: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliJ7N5W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J7N5W1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLFFRYGS MNSGKTIEIL KVAHNYEEQN KTVAIFTSGI DDRDQVGFIS
60 70 80 90 100
SRIGLKREAT PIFSDTNIFE IVANIKPKPN CVLLDESQFL EKEHVFQLAK
110 120 130 140 150
IVDELNIPVI AYGLKNDFRN ELFEGSKYLL LYADKLEEMK TICWFCAKKA
160 170 180 190
TMVLRVDDKG KPVYTGEQIM IGGNDHYYPV CRKCHANPPI K
Length:191
Mass (Da):21,849
Last modified:October 31, 2012 - v1
Checksum:i08E8DE9B0942A088
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR733646 Genomic DNA. Translation: CBY50142.1.
RefSeqiYP_006683000.1. NC_018587.1.

Genome annotation databases

EnsemblBacteriaiCBY50142; CBY50142; LMOSLCC2755_2550.
GeneIDi13599664.
KEGGilmw:LMOSLCC2755_2550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR733646 Genomic DNA. Translation: CBY50142.1 .
RefSeqi YP_006683000.1. NC_018587.1.

3D structure databases

ProteinModelPortali J7N5W1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBY50142 ; CBY50142 ; LMOSLCC2755_2550 .
GeneIDi 13599664.
KEGGi lmw:LMOSLCC2755_2550.

Phylogenomic databases

KOi K00857.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome."
    Kuenne C., Billion A., Mraheil M.A., Strittmatter A., Daniel R., Goesmann A., Barbuddhe S., Hain T., Chakraborty T.
    BMC Genomics 14:47-47(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SLCC2755Imported.

Entry informationi

Entry nameiJ7N5W1_LISMN
AccessioniPrimary (citable) accession number: J7N5W1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 26, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3