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J7M5B0

- J7M5B0_STRP1

UniProt

J7M5B0 - J7M5B0_STRP1

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptococcus pyogenes M1 476
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 2 (16 Oct 2013)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei155 – 1551UniRule annotation
    Active sitei600 – 6001UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, PyruvateImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcUniRule annotationImported
    ORF Names:M1GAS476_0559Imported
    OrganismiStreptococcus pyogenes M1 476Imported
    Taxonomic identifieri1207470 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000005248: Chromosome 1

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.UniRule annotation

    Phylogenomic databases

    KOiK01595.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    J7M5B0-1 [UniParc]FASTAAdd to Basket

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    MVKSGMIEET SKEGDGHLPL KKLESSNNQD IIAEEVALLK EMLENITRRM    50
    IGDDAFTVIE SIMVLSEKQD YIELEKVVAN ISNQEMEVIS RYFSILPLLI 100
    NISEDVDLAY EINYQNNTDT DYLGKLALTI KDLAGKDNGK DILEQVNVVP 150
    VLTAHPTQVQ RKTILELTTH IHKLLRKYRD AKAGVINLEK WRQELYRYIE 200
    MIMQTDIIRE KKLQVKNEIK NVMQYYDGSL IQAVTKLTTE YKNLAQKHGL 250
    ELDNPKPITM GMWIGGDRDG NPFVTAETLC LSATVQSEVI LNYYIDELAA 300
    LYRTFSLSST LVQPNSEVER LASLSQDQSI YRGNEPYRRA FHYIQSRLKQ 350
    TQIQLTNQPA ARMSSSVGLN TSAWSSPASL ENPILAYDSP VDFKADLKAI 400
    EQSLLDNGNS ALIEGDLREV MQAVDIFGFF LASIDMRQDS SVQEACVAEL 450
    LKGANIVDDY SSLSETEKCD VLLQQLMEEP RTLSSAAVAK SDLLEKELAI 500
    YTTARELKDK LGEEVIKQHI ISHTESVSDM FELAIMLKEV GLVDQQRARV 550
    QIVPLFETIE DLDNARDIMA AYLSHDIVKS WIATNRNYQE IMLGYSDSNK 600
    DGGYLASGWT LYKAQNELTA IGEEHGVKIT FFHGRGGTVG RGGGPSYDAI 650
    TSQPFGSIKD RIRLTEQGEI IENKYGNKDV AYYHLEMLIS ASINRMVTQM 700
    ITDPNEIDSF REIMDSIVAD SNIIYRKLVF DNPHFYDYFF EASPIKEVSS 750
    LNIGSRPAAR KTITEITGLR AIPWVFSWSQ NRIMFPGWYG VGSAFKRYID 800
    RAQGNLERLQ HMYQTWPFFH SLLSNVDMVL SKSNMNIAFQ YAQLAERQDV 850
    RDVFYEILDE WQLTKNVILA IQDHDALLED NPSLKHSLKS RLPYFNVLNY 900
    IQIELIKRWR NNQLDENDEK LIHTTINGIA TGLRNSG 937
    Length:937
    Mass (Da):106,576
    Last modified:October 16, 2013 - v2
    Checksum:i050CA83A2CC3D19F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012491 Genomic DNA. Translation: BAM29893.2.
    RefSeqiWP_011285453.1. NC_020540.2.
    YP_007587089.2. NC_020540.2.

    Genome annotation databases

    GeneIDi14820315.
    KEGGispym:M1GAS476_0559.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012491 Genomic DNA. Translation: BAM29893.2 .
    RefSeqi WP_011285453.1. NC_020540.2.
    YP_007587089.2. NC_020540.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 14820315.
    KEGGi spym:M1GAS476_0559.

    Phylogenomic databases

    KOi K01595.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of Streptococcus pyogenes M1 476, Isolated from a Patient with Streptococcal Toxic Shock Syndrome."
      Miyoshi-Akiyama T., Watanabe S., Kirikae T.
      J. Bacteriol. 194:5466-5466(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M1 476Imported.

    Entry informationi

    Entry nameiJ7M5B0_STRP1
    AccessioniPrimary (citable) accession number: J7M5B0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2012
    Last sequence update: October 16, 2013
    Last modified: October 1, 2014
    This is version 14 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3