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J7M5B0

- J7M5B0_STRP1

UniProt

J7M5B0 - J7M5B0_STRP1

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, M1GAS476_0559
Organism
Streptococcus pyogenes M1 476
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei155 – 1551 By similarityUniRule annotation
Active sitei600 – 6001 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotations

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
ORF Names:M1GAS476_0559Imported
OrganismiStreptococcus pyogenes M1 476Imported
Taxonomic identifieri1207470 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000005248: Chromosome 1

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J7M5B0-1 [UniParc]FASTAAdd to Basket

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MVKSGMIEET SKEGDGHLPL KKLESSNNQD IIAEEVALLK EMLENITRRM    50
IGDDAFTVIE SIMVLSEKQD YIELEKVVAN ISNQEMEVIS RYFSILPLLI 100
NISEDVDLAY EINYQNNTDT DYLGKLALTI KDLAGKDNGK DILEQVNVVP 150
VLTAHPTQVQ RKTILELTTH IHKLLRKYRD AKAGVINLEK WRQELYRYIE 200
MIMQTDIIRE KKLQVKNEIK NVMQYYDGSL IQAVTKLTTE YKNLAQKHGL 250
ELDNPKPITM GMWIGGDRDG NPFVTAETLC LSATVQSEVI LNYYIDELAA 300
LYRTFSLSST LVQPNSEVER LASLSQDQSI YRGNEPYRRA FHYIQSRLKQ 350
TQIQLTNQPA ARMSSSVGLN TSAWSSPASL ENPILAYDSP VDFKADLKAI 400
EQSLLDNGNS ALIEGDLREV MQAVDIFGFF LASIDMRQDS SVQEACVAEL 450
LKGANIVDDY SSLSETEKCD VLLQQLMEEP RTLSSAAVAK SDLLEKELAI 500
YTTARELKDK LGEEVIKQHI ISHTESVSDM FELAIMLKEV GLVDQQRARV 550
QIVPLFETIE DLDNARDIMA AYLSHDIVKS WIATNRNYQE IMLGYSDSNK 600
DGGYLASGWT LYKAQNELTA IGEEHGVKIT FFHGRGGTVG RGGGPSYDAI 650
TSQPFGSIKD RIRLTEQGEI IENKYGNKDV AYYHLEMLIS ASINRMVTQM 700
ITDPNEIDSF REIMDSIVAD SNIIYRKLVF DNPHFYDYFF EASPIKEVSS 750
LNIGSRPAAR KTITEITGLR AIPWVFSWSQ NRIMFPGWYG VGSAFKRYID 800
RAQGNLERLQ HMYQTWPFFH SLLSNVDMVL SKSNMNIAFQ YAQLAERQDV 850
RDVFYEILDE WQLTKNVILA IQDHDALLED NPSLKHSLKS RLPYFNVLNY 900
IQIELIKRWR NNQLDENDEK LIHTTINGIA TGLRNSG 937
Length:937
Mass (Da):106,576
Last modified:October 16, 2013 - v2
Checksum:i050CA83A2CC3D19F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012491 Genomic DNA. Translation: BAM29893.2.
RefSeqiWP_011285453.1. NC_020540.2.
YP_007587089.2. NC_020540.2.

Genome annotation databases

GeneIDi14820315.
KEGGispym:M1GAS476_0559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012491 Genomic DNA. Translation: BAM29893.2 .
RefSeqi WP_011285453.1. NC_020540.2.
YP_007587089.2. NC_020540.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 14820315.
KEGGi spym:M1GAS476_0559.

Phylogenomic databases

KOi K01595.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Streptococcus pyogenes M1 476, Isolated from a Patient with Streptococcal Toxic Shock Syndrome."
    Miyoshi-Akiyama T., Watanabe S., Kirikae T.
    J. Bacteriol. 194:5466-5466(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M1 476Imported.

Entry informationi

Entry nameiJ7M5B0_STRP1
AccessioniPrimary (citable) accession number: J7M5B0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 16, 2013
Last modified: September 3, 2014
This is version 13 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi