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J7LSH9

- J7LSH9_9MICC

UniProt

J7LSH9 - J7LSH9_9MICC

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Protein

Malate dehydrogenase

Gene
mdh, ARUE_c05390
Organism
Arthrobacter sp. Rue61a
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate By similarityUniRule annotation
Binding sitei98 – 981Substrate By similarityUniRule annotation
Binding sitei105 – 1051NAD By similarityUniRule annotation
Binding sitei112 – 1121NAD By similarityUniRule annotation
Binding sitei131 – 1311Substrate By similarityUniRule annotation
Binding sitei162 – 1621Substrate By similarityUniRule annotation
Active sitei187 – 1871Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 177NAD By similarityUniRule annotation
Nucleotide bindingi129 – 1313NAD By similarityUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotationSAAS annotations

Keywords - Ligandi

NADUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotationImported
ORF Names:ARUE_c05390Imported
OrganismiArthrobacter sp. Rue61aImported
Taxonomic identifieri1118963 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000003736: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00024.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J7LSH9-1 [UniParc]FASTAAdd to Basket

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MSSPIKIAVT GAAGQIGYSL LFRIASGALF GGDSPVQLRL LEITPALKAL    50
EGVVMELDDC AFPALDSVEI GDDADHIFDG VNLALLVGAR PRSKGMERGD 100
LLSANGDIFT AQGKALNRVA ADDVRIGVTG NPANTNALIA MSNAPDIPAS 150
RFSALTRLDH NRAIGQLAAK THARVGDIRK MTVWGNHSAT QYPDIFHAEV 200
AGRNAAEVVN DQDWIENEFI PTVAGRGAAI IEARGASSAA SAASATIDAA 250
RDWLLGTPEG DWVSMAVASD GSYGVPEGLM YSYPVTTSGG NWEIVEGLEV 300
NDFSRRKMDA TAAELFDERA AVAELGLI 328
Length:328
Mass (Da):34,436
Last modified:October 31, 2012 - v1
Checksum:i6FF01CBDA7D3F9F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003203 Genomic DNA. Translation: AFR27474.1.
RefSeqiWP_014920645.1. NC_018531.1.
YP_006660512.1. NC_018531.1.

Genome annotation databases

EnsemblBacteriaiAFR27474; AFR27474; ARUE_c05390.
GeneIDi13561512.
KEGGiarr:ARUE_c05390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003203 Genomic DNA. Translation: AFR27474.1 .
RefSeqi WP_014920645.1. NC_018531.1.
YP_006660512.1. NC_018531.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFR27474 ; AFR27474 ; ARUE_c05390 .
GeneIDi 13561512.
KEGGi arr:ARUE_c05390.

Phylogenomic databases

KOi K00024.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and metabolic potential of the quinaldine-degrading bacterium Arthrobacter sp. Rue61a."
    Niewerth H., Schuldes J., Parschat K., Kiefer P., Vorholt J.A., Daniel R., Fetzner S.
    BMC Genomics 13:534-534(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rue61aImported.

Entry informationi

Entry nameiJ7LSH9_9MICC
AccessioniPrimary (citable) accession number: J7LSH9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 3, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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