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J7LSH9 (J7LSH9_9MICC) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. RuleBase RU000422 HAMAP-Rule MF_01517 SAAS SAAS010945

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01517

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. RuleBase RU000421 HAMAP-Rule MF_01517

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 177NAD By similarity HAMAP-Rule MF_01517
Nucleotide binding129 – 1313NAD By similarity HAMAP-Rule MF_01517

Sites

Active site1871Proton acceptor By similarity HAMAP-Rule MF_01517
Binding site921Substrate By similarity HAMAP-Rule MF_01517
Binding site981Substrate By similarity HAMAP-Rule MF_01517
Binding site1051NAD By similarity HAMAP-Rule MF_01517
Binding site1121NAD By similarity HAMAP-Rule MF_01517
Binding site1311Substrate By similarity HAMAP-Rule MF_01517
Binding site1621Substrate By similarity HAMAP-Rule MF_01517

Sequences

Sequence LengthMass (Da)Tools
J7LSH9 [UniParc].

Last modified October 31, 2012. Version 1.
Checksum: 6FF01CBDA7D3F9F0

FASTA32834,436
        10         20         30         40         50         60 
MSSPIKIAVT GAAGQIGYSL LFRIASGALF GGDSPVQLRL LEITPALKAL EGVVMELDDC 

        70         80         90        100        110        120 
AFPALDSVEI GDDADHIFDG VNLALLVGAR PRSKGMERGD LLSANGDIFT AQGKALNRVA 

       130        140        150        160        170        180 
ADDVRIGVTG NPANTNALIA MSNAPDIPAS RFSALTRLDH NRAIGQLAAK THARVGDIRK 

       190        200        210        220        230        240 
MTVWGNHSAT QYPDIFHAEV AGRNAAEVVN DQDWIENEFI PTVAGRGAAI IEARGASSAA 

       250        260        270        280        290        300 
SAASATIDAA RDWLLGTPEG DWVSMAVASD GSYGVPEGLM YSYPVTTSGG NWEIVEGLEV 

       310        320 
NDFSRRKMDA TAAELFDERA AVAELGLI 

« Hide

References

[1]"Complete genome sequence and metabolic potential of the quinaldine-degrading bacterium Arthrobacter sp. Rue61a."
Niewerth H., Schuldes J., Parschat K., Kiefer P., Vorholt J.A., Daniel R., Fetzner S.
BMC Genomics 13:534-534(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Rue61a EMBL AFR27474.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003203 Genomic DNA. Translation: AFR27474.1.
RefSeqYP_006660512.1. NC_018531.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFR27474; AFR27474; ARUE_c05390.
GeneID13561512.
KEGGarr:ARUE_c05390.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00024.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_01517. Malate_dehydrog_2.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23382. PTHR23382. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJ7LSH9_9MICC
AccessionPrimary (citable) accession number: J7LSH9
Entry history
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: June 11, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)