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J7LQ38 (J7LQ38_9MICC) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFR29530.1
ORF Names:ARUE_c26360 EMBL AFR29530.1
OrganismArthrobacter sp. Rue61a [Complete proteome] EMBL AFR29530.1
Taxonomic identifier1118963 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain157 – 368212ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding189 – 24456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3221Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3351Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3351Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3371Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
J7LQ38 [UniParc].

Last modified October 31, 2012. Version 1.
Checksum: 912B80574B38828F

FASTA37839,981
        10         20         30         40         50         60 
MVTDHSTPVT GRPRVAILFG GRSSEHAVSC VTAAGVMGAI DKNKYEVIPI GIAKSGQWVL 

        70         80         90        100        110        120 
ASGDTSEWSL SSAALPEVAP SGRTVTLAEV GGEHQLIVTE PNAVPQELGS VDVVFPLLHG 

       130        140        150        160        170        180 
PWGEDGTIQG LLELSDTRYV GAGVLASAVG MDKHFMKVVF ESAGLSVGPY VAVTDREWST 

       190        200        210        220        230        240 
DAEAVRKRVD KLGFPVFVKP ARAGSSMGIS KVDSMEGLDA AIDEARRHDL KLVIEAGIVG 

       250        260        270        280        290        300 
REIECAVLQG RGTDAPRTSM PGEIAVAVGE HQFYDFAAKY VEDGAAALSC PADMPDEAIA 

       310        320        330        340        350        360 
RVRELAAVAF DAVGAEGLSR VDFFYTPAGE LIINEINTMP GFTPKSMYPQ MWAASGLAYG 

       370 
DLIDELIHLA LTRKTGLR 

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References

[1]"Complete genome sequence and metabolic potential of the quinaldine-degrading bacterium Arthrobacter sp. Rue61a."
Niewerth H., Schuldes J., Parschat K., Kiefer P., Vorholt J.A., Daniel R., Fetzner S.
BMC Genomics 13:534-534(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Rue61a EMBL AFR29530.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003203 Genomic DNA. Translation: AFR29530.1.
RefSeqYP_006662568.1. NC_018531.1.

3D structure databases

ProteinModelPortalJ7LQ38.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFR29530; AFR29530; ARUE_c26360.
GeneID13561925.
KEGGarr:ARUE_c26360.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJ7LQ38_9MICC
AccessionPrimary (citable) accession number: J7LQ38
Entry history
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: February 19, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)