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J7LCN6 (J7LCN6_NOCAA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFR08262.1
Ordered Locus Names:B005_3035 EMBL AFR08262.1
OrganismNocardiopsis alba (strain ATCC BAA-2165 / BE74) [Complete proteome] [HAMAP] EMBL AFR08262.1
Taxonomic identifier1205910 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeNocardiopsis

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain153 – 364212ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding185 – 24359ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3181Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3311Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3311Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3331Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
J7LCN6 [UniParc].

Last modified October 31, 2012. Version 1.
Checksum: A8E75C9AF102E10F

FASTA37439,944
        10         20         30         40         50         60 
MSSEQRKIRI AVVFGGRSSE HEISCVTAGS VLSVIDPDRY EVVPVGITRT GNWVLASGDP 

        70         80         90        100        110        120 
ENLRIDPATK ALPSVSEDGL ELALPFDTAG QLMTVSPSRG TERLAEVDVV LPLLHGPFGE 

       130        140        150        160        170        180 
DGTIQGLFEM MGVRYAGAGV FSSAAAMDKV FMKAMLVGNG IPTSPYVAIT ARAWETERKK 

       190        200        210        220        230        240 
VLDDIAELGT TVFVKPARAG SSVGISKVRD SGDADAVVAA VEAAREHDPK VLVEAQVVGR 

       250        260        270        280        290        300 
EIECGVLESE DGGTPDVSFP AEVHVAEGFD FYDFEAKYLS TSGLTIPAEI PEEATARLRA 

       310        320        330        340        350        360 
MAADVFEAMG CEGLARVDFF YTEDGEVLVN ELNTMPGFTP SSAFPQMWEA TGVDYATLVE 

       370 
RMITTALRRS PGLR 

« Hide

References

[1]"Whole-genome sequence of Nocardiopsis alba strain ATCC BAA-2165 associated with honeybees."
Qiao J., Chen L., Li Y., Wang J., Zhang W., Chen S.
Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-2165 / BE74.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003788 Genomic DNA. Translation: AFR08262.1.
RefSeqYP_006642113.1. NC_018524.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFR08262; AFR08262; B005_3035.
GeneID13546416.
KEGGnal:B005_3035.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJ7LCN6_NOCAA
AccessionPrimary (citable) accession number: J7LCN6
Entry history
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: February 19, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)