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J7KMQ4

- J7KMQ4_STRSU

UniProt

J7KMQ4 - J7KMQ4_STRSU

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Protein

Isocitrate dehydrogenase [NADP]

Gene

YYK_04955

Organism
Streptococcus suis S735
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:YYK_04955Imported
OrganismiStreptococcus suis S735Imported
Taxonomic identifieri1184252 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000003785: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J7KMQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEKILMREG RLIVPDCPVI PYIEGDGIGR DIWSVSQKVI DAAVKKAYAG
60 70 80 90 100
QRSIQWREVF AGEKAYELMG TSLPNETLEI IREHLVAIKG PLGTPIGKGH
110 120 130 140 150
RSLNVALRQE LDLYACVRPI RYFKGVPSPL KEPEKTDITI FRENTEDIYA
160 170 180 190 200
GIEWEAGSDE VAKVISFLQE EMGVVNIRFP ESSSIGIKPI SEEGSKRLIR
210 220 230 240 250
SAIEYALEHQ LKMVTLVHKG NIQKFTEGGF RKWGYELAKE EFATELAEGT
260 270 280 290 300
LVVNDIIADN FLQQILLAPE NFQVVALTNL NGDYASDALA AQVGGIGISP
310 320 330 340 350
GANINYQTGH AIFEATHGTA PDIAGKDLAN PCSLLLSACM MLEYIGWKEA
360 370 380 390
AVLIIQALED AFINKNVTLD FAKILDVAHQ STSQFSEVLI DSI
Length:393
Mass (Da):43,247
Last modified:October 31, 2012 - v1
Checksum:i60138A369089D381
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003736 Genomic DNA. Translation: AFR00510.1.
RefSeqiYP_006649908.1. NC_018526.1.

Genome annotation databases

EnsemblBacteriaiAFR00510; AFR00510; YYK_04955.
GeneIDi13537949.
KEGGisup:YYK_04955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003736 Genomic DNA. Translation: AFR00510.1 .
RefSeqi YP_006649908.1. NC_018526.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFR00510 ; AFR00510 ; YYK_04955 .
GeneIDi 13537949.
KEGGi sup:YYK_04955.

Phylogenomic databases

KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome Sequence of the Swine Pathogen Streptococcus suis Serotype 2 Strain S735."
    Boyle B., Vaillancourt K., Bonifait L., Charette S.J., Gottschalk M., Grenier D.
    J. Bacteriol. 194:6343-6344(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S735Imported.

Entry informationi

Entry nameiJ7KMQ4_STRSU
AccessioniPrimary (citable) accession number: J7KMQ4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 26, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3