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J7KMQ4

- J7KMQ4_STRSU

UniProt

J7KMQ4 - J7KMQ4_STRSU

Protein

Isocitrate dehydrogenase [NADP]

Gene

YYK_04955

Organism
Streptococcus suis S735
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:YYK_04955Imported
    OrganismiStreptococcus suis S735Imported
    Taxonomic identifieri1184252 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000003785: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    J7KMQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKILMREG RLIVPDCPVI PYIEGDGIGR DIWSVSQKVI DAAVKKAYAG    50
    QRSIQWREVF AGEKAYELMG TSLPNETLEI IREHLVAIKG PLGTPIGKGH 100
    RSLNVALRQE LDLYACVRPI RYFKGVPSPL KEPEKTDITI FRENTEDIYA 150
    GIEWEAGSDE VAKVISFLQE EMGVVNIRFP ESSSIGIKPI SEEGSKRLIR 200
    SAIEYALEHQ LKMVTLVHKG NIQKFTEGGF RKWGYELAKE EFATELAEGT 250
    LVVNDIIADN FLQQILLAPE NFQVVALTNL NGDYASDALA AQVGGIGISP 300
    GANINYQTGH AIFEATHGTA PDIAGKDLAN PCSLLLSACM MLEYIGWKEA 350
    AVLIIQALED AFINKNVTLD FAKILDVAHQ STSQFSEVLI DSI 393
    Length:393
    Mass (Da):43,247
    Last modified:October 31, 2012 - v1
    Checksum:i60138A369089D381
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003736 Genomic DNA. Translation: AFR00510.1.
    RefSeqiYP_006649908.1. NC_018526.1.

    Genome annotation databases

    EnsemblBacteriaiAFR00510; AFR00510; YYK_04955.
    GeneIDi13537949.
    KEGGisup:YYK_04955.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003736 Genomic DNA. Translation: AFR00510.1 .
    RefSeqi YP_006649908.1. NC_018526.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFR00510 ; AFR00510 ; YYK_04955 .
    GeneIDi 13537949.
    KEGGi sup:YYK_04955.

    Phylogenomic databases

    KOi K00031.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome Sequence of the Swine Pathogen Streptococcus suis Serotype 2 Strain S735."
      Boyle B., Vaillancourt K., Bonifait L., Charette S.J., Gottschalk M., Grenier D.
      J. Bacteriol. 194:6343-6344(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S735Imported.

    Entry informationi

    Entry nameiJ7KMQ4_STRSU
    AccessioniPrimary (citable) accession number: J7KMQ4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2012
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3