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Protein

Alpha-conotoxin VxXXIVA

Gene
N/A
Organism
Conus vexillum (Flag cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. The toxin with a disulfide connectivity C1-C2, C3-C4 (shown in the sequence annotation) block the rat nicotinic acetylcholine receptor (AChR) alpha-9-alpha-10/CHRNA9-CHRNA10 with an IC50 of 1.2 µM, whereas the one with C1-C3, C2-C4 shows a lower activity with an IC50 of 3.9 µM.1 Publication

Miscellaneous

The 3 disulfide isomers are poorly structured in aqueous solution.1 Publication
The toxin (with connectivity C1-C2, C3-C4) does not have inhibitory effect on alpha-2-beta-4/CHRNA2-CHRNB4, alpha-3-beta-2/CHRNA3-CHRNB2, alpha-3-beta-4/CHRNA3-CHRNB4, alpha-4-beta-2/CHRNA4-CHRNB2, alpha-4-beta-4/CHRNA4-CHRNB4 and alpha-7/CHRNA7. The toxin (with connectivity C1-C4, C2-C3) does not have inhibitory effect on alpha-9-alpha-10/CHRNA9-CHRNA10 (PubMed:23382933).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin VxXXIVA
Alternative name(s):
AlphaB-conotoxin VxXXIVA
OrganismiConus vexillum (Flag cone)
Taxonomic identifieri89431 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri5525. VxXXIVA precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000042288229 – 68Alpha-conotoxin VxXXIVAAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 47Curated
Disulfide bondi48 ↔ 60Curated

Post-translational modificationi

The 3 possibles disulfide-bond connectivities isomers have been synthesized: (C1-C2, C3-C4), (C1-C3, C2-C4), and (C1-C4, C2-C3).1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is XXIV (C-CC-C).

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

J7JU64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLTLLWRA SSSCLLVVLS HSLLRLLGVR CLEKSGAQPN KLFRPPCCQK
60
GPSFARHSRC VYYTQSRE
Length:68
Mass (Da):7,724
Last modified:October 31, 2012 - v1
Checksum:iBD9221F8BF7BA01A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX297421 mRNA. Translation: AFQ60002.1.

Entry informationi

Entry nameiCBOA_CONVX
AccessioniPrimary (citable) accession number: J7JU64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families