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J7J9L0

- J7J9L0_BURCE

UniProt

J7J9L0 - J7J9L0_BURCE

Protein

Alanine racemase

Gene

GEM_4542

Organism
Burkholderia cepacia GG4
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (31 Oct 2012)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei130 – 1301SubstrateUniRule annotation
    Active sitei252 – 2521Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei300 – 3001Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    ORF Names:GEM_4542Imported
    OrganismiBurkholderia cepacia GG4Imported
    Taxonomic identifieri1009846 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliJ7J9L0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    J7J9L0-1 [UniParc]FASTAAdd to Basket

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    MPRPIVAHIR PDAVRHNLDF IRRTAAQSRV WAVIKANAYG HGVERIYPGL    50
    AAADGIALLD LDEAVRVREL GWDKPVLLLE GIFEPADVEL ADRHRLTVAV 100
    HCDQQLDLLI AAKPQQPIDI QLKMNSGMNR LGYRPDAFRA AWERAAAAPS 150
    IGKITLMMHF ANADEGEVDW QLEQFDATTA GIPGERSASN SAAVLWHPRA 200
    HRDWVRPGTI LYGASPTGAA RHIADTPLMA AMTLTSKIIG VQTLAPEETV 250
    GYGRRFTVDR PMRIGVVACG YADGYPRHAP TGTPIAVDGV MTRVVGRVSM 300
    DMLTVDLTPC PNAGIGSSVE LWGDQVKVDD VAEASGTIGY ELMCALARRV 350
    PVVIEPPGAS TLQPALRTGS YGR 373
    Length:373
    Mass (Da):40,354
    Last modified:October 31, 2012 - v1
    Checksum:iCB1342090FFC6DBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003775 Genomic DNA. Translation: AFQ50932.1.
    RefSeqiWP_014899697.1. NC_018514.1.
    YP_006618626.1. NC_018514.1.

    Genome annotation databases

    EnsemblBacteriaiAFQ50932; AFQ50932; GEM_4542.
    GeneIDi13509567.
    KEGGibct:GEM_4542.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003775 Genomic DNA. Translation: AFQ50932.1 .
    RefSeqi WP_014899697.1. NC_018514.1.
    YP_006618626.1. NC_018514.1.

    3D structure databases

    ProteinModelPortali J7J9L0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFQ50932 ; AFQ50932 ; GEM_4542 .
    GeneIDi 13509567.
    KEGGi bct:GEM_4542.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of Burkholderia sp. Strain GG4, a Betaproteobacterium That Reduces 3-Oxo-N-Acylhomoserine Lactones and Produces Different N-Acylhomoserine Lactones."
      Hong K.W., Koh C.L., Sam C.K., Yin W.F., Chan K.G.
      J. Bacteriol. 194:6317-6317(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GG4Imported.

    Entry informationi

    Entry nameiJ7J9L0_BURCE
    AccessioniPrimary (citable) accession number: J7J9L0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2012
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)