J7GBH1 (J7GBH1_ENTCL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446
EC=1.1.1.42 RuleBase RU004446

Gene names

ORF Names:

ECENHK_08795 EMBL AFP69636.1

Organism

Enterobacter cloacae subsp. cloacae ENHKU01 EMBL AFP69636.1

Taxonomic identifier

1211025 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Enterobacter › Enterobacter cloacae complex › Enterobacter cloacae › Enterobacter cloacae subsp. cloacae

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Ontologies

Keywords
Biological process	Glyoxylate bypass RuleBase RU004446 Tricarboxylic acid cycle RuleBase RU004446
Ligand	Manganese RuleBase RU004446 Metal-binding RuleBase RU004446 NADP RuleBase RU004446
Molecular function	Oxidoreductase RuleBase RU004444 EMBL AFP69636.1
Gene Ontology (GO)
Biological_process	glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	J7GBH1 [UniParc]. Last modified October 31, 2012. Version 1. Checksum: 1B65E7CEE5C2C372	FASTA	416	45,827
	10 20 30 40 50 60 MESKVVVPAE GKKITLQNGK INVPHNPIIP FIEGDGIGVD VTPAMLKVVD AAVEKAYKGE 70 80 90 100 110 120 RKISWMEIYT GEKSTQVYGQ DVWLPAETLD LIRDYRVAIK GPLTTPVGGG IRSLNVALRQ 130 140 150 160 170 180 ELDLYVCLRP VRYYQGTPSP VKHPELTDMV IFRENSEDIY AGIEWKADSA DAEKVIKFLR 190 200 210 220 230 240 EEMGVKKIRF PEHCGIGIKP CSEEGTKRLV RAAIEYAITN DRDSVTLVHK GNIMKFTEGA 250 260 270 280 290 300 FKDWGYQLAK EEFGGELIDG GPWQKIKNPN TGKEIIVKDV IADAFLQQIL LRPAEYDVIA 310 320 330 340 350 360 CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK VNPGSIILSA 370 380 390 400 410 EMMLRHMEWF EAADLIVKGM EGAINAKTVT YDFERLMEGA KLLKCSEFGD AIIANM

References

[1]	"Complete Genome Sequence of the Endophytic Enterobacter cloacae subsp. cloacae Strain ENHKU01." Liu W.Y., Chung K.M., Wong C.F., Jiang J.W., Hui R.K., Leung F.C. J. Bacteriol. 194:5965-5965(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ENHKU01 EMBL AFP69636.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP003737 Genomic DNA. Translation: AFP69636.1.
RefSeq	YP_006578260.1. NC_018405.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AFP69636; AFP69636; ECENHK_08795.
GeneID	13456500.
KEGG	eno:ECENHK_08795.
Phylogenomic databases
KO	K00031.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR004439. Isocitrate_DH_NADP_dimer_prok. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PANTHER	PTHR11835. PTHR11835. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR00183. prok_nadp_idh. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

J7GBH1_ENTCL

Accession

Primary (citable) accession number: J7GBH1

Entry history

Integrated into UniProtKB/TrEMBL:	October 31, 2012
Last sequence update:	October 31, 2012
Last modified:	April 3, 2013
This is version 6 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)