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J7GBH1

- J7GBH1_ENTCL

UniProt

J7GBH1 - J7GBH1_ENTCL

Protein

Isocitrate dehydrogenase [NADP]

Gene

ECENHK_08795

Organism
Enterobacter cloacae subsp. cloacae ENHKU01
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:ECENHK_08795Imported
    OrganismiEnterobacter cloacae subsp. cloacae ENHKU01Imported
    Taxonomic identifieri1211025 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
    ProteomesiUP000003928: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    J7GBH1-1 [UniParc]FASTAAdd to Basket

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    MESKVVVPAE GKKITLQNGK INVPHNPIIP FIEGDGIGVD VTPAMLKVVD    50
    AAVEKAYKGE RKISWMEIYT GEKSTQVYGQ DVWLPAETLD LIRDYRVAIK 100
    GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV 150
    IFRENSEDIY AGIEWKADSA DAEKVIKFLR EEMGVKKIRF PEHCGIGIKP 200
    CSEEGTKRLV RAAIEYAITN DRDSVTLVHK GNIMKFTEGA FKDWGYQLAK 250
    EEFGGELIDG GPWQKIKNPN TGKEIIVKDV IADAFLQQIL LRPAEYDVIA 300
    CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK 350
    VNPGSIILSA EMMLRHMEWF EAADLIVKGM EGAINAKTVT YDFERLMEGA 400
    KLLKCSEFGD AIIANM 416
    Length:416
    Mass (Da):45,827
    Last modified:October 31, 2012 - v1
    Checksum:i1B65E7CEE5C2C372
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003737 Genomic DNA. Translation: AFP69636.1.
    RefSeqiYP_006578260.1. NC_018405.1.

    Genome annotation databases

    EnsemblBacteriaiAFP69636; AFP69636; ECENHK_08795.
    GeneIDi13456500.
    KEGGieno:ECENHK_08795.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003737 Genomic DNA. Translation: AFP69636.1 .
    RefSeqi YP_006578260.1. NC_018405.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFP69636 ; AFP69636 ; ECENHK_08795 .
    GeneIDi 13456500.
    KEGGi eno:ECENHK_08795.

    Phylogenomic databases

    KOi K00031.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of the Endophytic Enterobacter cloacae subsp. cloacae Strain ENHKU01."
      Liu W.Y., Chung K.M., Wong C.F., Jiang J.W., Hui R.K., Leung F.C.
      J. Bacteriol. 194:5965-5965(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ENHKU01Imported.

    Entry informationi

    Entry nameiJ7GBH1_ENTCL
    AccessioniPrimary (citable) accession number: J7GBH1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2012
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3