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J3WW19 (J3WW19_BACTU) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFQ14822.1
ORF Names:BTG_06680 EMBL AFQ14822.1
OrganismBacillus thuringiensis HD-771 [Complete proteome] EMBL AFQ14822.1
Taxonomic identifier1218175 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain99 – 293195ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding126 – 18156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2481Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2601Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2601Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2621Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
J3WW19 [UniParc].

Last modified October 31, 2012. Version 1.
Checksum: 73238A408371F731

FASTA30433,761
        10         20         30         40         50         60 
MKIGVIMGGV SSEKQVSIMT GNEMIAHLDK NKYEIVPITL NEKMDLIEKA KDIDFALLAL 

        70         80         90        100        110        120 
HGKYGEDGTV QGTLESLGIP YSGSNMLSSS ICMDKNISKK ILRYEGVETP DWIELTKMED 

       130        140        150        160        170        180 
LKLDELDKLG FPLVVKPNSG GSSVGVKIVY NKNELISMLE TVFEWDSEVV IEKYVKGDEI 

       190        200        210        220        230        240 
TCSILDGKQL PIVSIRHAAE FFDYNAKYDD TSTVEEVIEL PAEINERVNK ASLACYKVLK 

       250        260        270        280        290        300 
CSVYARVDMM VKDGIPYVME INTLPGMTQS SLLPKSAEAA GISYSKLLDM IIETSLKVRK 


EEGF 

« Hide

References

[1]Doggett N., Teshima H., Bruce D., Detter J.C., Johnson S.L., Han C.
Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HD-771 EMBL AFQ14822.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003752 Genomic DNA. Translation: AFQ14822.1.
RefSeqYP_006602855.1. NC_018500.1.

3D structure databases

ProteinModelPortalJ3WW19.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFQ14822; AFQ14822; BTG_06680.
GeneID13497513.
KEGGbti:BTG_06680.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJ3WW19_BACTU
AccessionPrimary (citable) accession number: J3WW19
Entry history
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: June 11, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)