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J3VJ07

- J3VJ07_MYCGL

UniProt

J3VJ07 - J3VJ07_MYCGL

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Protein

Thymidine kinase

Gene
tdk, HFMG06NCA_5020
Organism
Mycoplasma gallisepticum NC06_2006.080-5-2P
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptor By similarityUniRule annotation
Metal bindingi150 – 1501Zinc By similarityUniRule annotation
Metal bindingi153 – 1531Zinc By similarityUniRule annotation
Metal bindingi188 – 1881Zinc By similarityUniRule annotation
Metal bindingi191 – 1911Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268ATP By similarityUniRule annotation
Nucleotide bindingi93 – 964ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:HFMG06NCA_5020Imported
OrganismiMycoplasma gallisepticum NC06_2006.080-5-2PImported
Taxonomic identifieri1159202 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000003941: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliJ3VJ07.
SMRiJ3VJ07. Positions 12-212.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

J3VJ07-1 [UniParc]FASTAAdd to Basket

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MAKKNAMTTT NGWIEAICGP MFAGKTDELI RKIKRYEYAD VKSLVFSPAT    50
DTRSAQEIIN SRDGRRIGSI KIKKAFEIYD YVLLHKPQLV GIDEVQFFDD 100
SIVEVIQTLA DNQINVIVAG LDRDFRGEPF GPIPKILGIA ESVIRLTAIC 150
SECGAEASRS QRLIDNQPAD YNCETILIGD TESYAPRCRH HHKVPNRPIN 200
DQTKNFKRAL KNNFDKIVEQ SSKD 224
Length:224
Mass (Da):25,259
Last modified:October 31, 2012 - v1
Checksum:i8674C04BE5741FCC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003511 Genomic DNA. Translation: AFP80023.1.
RefSeqiYP_006585342.1. NC_018411.1.

Genome annotation databases

EnsemblBacteriaiAFP80023; AFP80023; HFMG06NCA_5020.
GeneIDi13464514.
KEGGimgn:HFMG06NCA_5020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003511 Genomic DNA. Translation: AFP80023.1 .
RefSeqi YP_006585342.1. NC_018411.1.

3D structure databases

ProteinModelPortali J3VJ07.
SMRi J3VJ07. Positions 12-212.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFP80023 ; AFP80023 ; HFMG06NCA_5020 .
GeneIDi 13464514.
KEGGi mgn:HFMG06NCA_5020.

Phylogenomic databases

KOi K00857.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Extensive variation in surface lipoprotein gene content and genomic changes associated with virulence during evolution of a novel North American house finch epizootic strain of Mycoplasma gallisepticum."
    Tulman E.R., Liao X., Szczepanek S.M., Ley D.H., Kutish G.F., Geary S.J.
    Microbiology 158:2073-2088(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NC06_2006.080-5-2PImported.

Entry informationi

Entry nameiJ3VJ07_MYCGL
AccessioniPrimary (citable) accession number: J3VJ07
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 3, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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