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J3UH26

- J3UH26_BACTU

UniProt

J3UH26 - J3UH26_BACTU

Protein

Kynureninase

Gene

kynU

Organism
Bacillus thuringiensis HD-789
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei104 – 1041Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei105 – 1051Pyridoxal phosphateUniRule annotation
    Binding sitei213 – 2131Pyridoxal phosphateUniRule annotation
    Binding sitei216 – 2161Pyridoxal phosphateUniRule annotation
    Binding sitei238 – 2381Pyridoxal phosphateUniRule annotation
    Binding sitei267 – 2671Pyridoxal phosphateUniRule annotation
    Binding sitei295 – 2951Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    ORF Names:BTF1_11305Imported
    OrganismiBacillus thuringiensis HD-789Imported
    Taxonomic identifieri1217737 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000005257: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei239 – 2391N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliJ3UH26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni132 – 1354Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    KOiK01556.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    J3UH26-1 [UniParc]FASTAAdd to Basket

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    MYKEPFQPTY EYALECDKHD ELKDFQTEFY KKEGTIYLDG NSLGLLSKRA    50
    EKSLLTLLDS WKEYGIDGWT EGEHPWFFLS EKLGKLTAPL IGALPEETIV 100
    TGSTTTNIHQ VIATFYEPKG IRTKILADEL TFPSDIYALQ SQIRLKGLDP 150
    DEHLVRVKSR DGRTLSEEDI IHAMEDDIAL ILLPSVLYRS GQILDMKRLT 200
    TEAHKRDIHI GFDLCHSIGS IPHHFKDWDV DFAVWCNYKY LNAGPGSVAG 250
    LYVNNKHFNR LPGLSGWFSS KKDKQFDMEH TLTAADHAGA YQIGTPHVLS 300
    IAPLIGSLEI FKDAGIERLR EKSLHITRYM LNLIDHELKD FGFTIGNPLE 350
    DESRGGHIYL EHAEAARICK ALKANGVIPD FRAPNGVRLA PVALYNTYEE 400
    VWKSVQILKG IMKEEKYKQF ENKREVVA 428
    Length:428
    Mass (Da):48,697
    Last modified:October 31, 2012 - v1
    Checksum:iF67770C7C10FA1CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003763 Genomic DNA. Translation: AFQ26456.1.
    RefSeqiYP_006610376.1. NC_018508.1.

    Genome annotation databases

    EnsemblBacteriaiAFQ26456; AFQ26456; BTF1_11305.
    GeneIDi13501598.
    KEGGibtn:BTF1_11305.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003763 Genomic DNA. Translation: AFQ26456.1 .
    RefSeqi YP_006610376.1. NC_018508.1.

    3D structure databases

    ProteinModelPortali J3UH26.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFQ26456 ; AFQ26456 ; BTF1_11305 .
    GeneIDi 13501598.
    KEGGi btn:BTF1_11305.

    Phylogenomic databases

    KOi K01556.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of Bacillus thuringiensis Serovar Israelensis Strain HD-789."
      Doggett N.A., Stubben C.J., Chertkov O., Bruce D.C., Detter J.C., Johnson S.L., Han C.S.
      Genome Announc. 1:e01023-13(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HD-789Imported.

    Entry informationi

    Entry nameiJ3UH26_BACTU
    AccessioniPrimary (citable) accession number: J3UH26
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 31, 2012
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3