Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

J3UH26 (J3UH26_BACTU) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Kynureninase PIRNR PIRNR038800 HAMAP-Rule MF_01970

EC=3.7.1.3 PIRNR PIRNR038800 HAMAP-Rule MF_01970
Alternative name(s):
L-kynurenine hydrolase HAMAP-Rule MF_01970
Gene names
Name:kynU HAMAP-Rule MF_01970
ORF Names:BTF1_11305 EMBL AFQ26456.1
OrganismBacillus thuringiensis HD-789 [Complete proteome] EMBL AFQ26456.1
Taxonomic identifier1217737 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 HAMAP-Rule MF_01970

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800 HAMAP-Rule MF_01970

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region132 – 1354Pyridoxal phosphate binding By similarity HAMAP-Rule MF_01970

Sites

Binding site1041Pyridoxal phosphate; via amide nitrogen By similarity HAMAP-Rule MF_01970
Binding site1051Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2131Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2161Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2381Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2671Pyridoxal phosphate By similarity HAMAP-Rule MF_01970
Binding site2951Pyridoxal phosphate By similarity HAMAP-Rule MF_01970

Amino acid modifications

Modified residue2391N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01970

Sequences

Sequence LengthMass (Da)Tools
J3UH26 [UniParc].

Last modified October 31, 2012. Version 1.
Checksum: F67770C7C10FA1CE

FASTA42848,697
        10         20         30         40         50         60 
MYKEPFQPTY EYALECDKHD ELKDFQTEFY KKEGTIYLDG NSLGLLSKRA EKSLLTLLDS 

        70         80         90        100        110        120 
WKEYGIDGWT EGEHPWFFLS EKLGKLTAPL IGALPEETIV TGSTTTNIHQ VIATFYEPKG 

       130        140        150        160        170        180 
IRTKILADEL TFPSDIYALQ SQIRLKGLDP DEHLVRVKSR DGRTLSEEDI IHAMEDDIAL 

       190        200        210        220        230        240 
ILLPSVLYRS GQILDMKRLT TEAHKRDIHI GFDLCHSIGS IPHHFKDWDV DFAVWCNYKY 

       250        260        270        280        290        300 
LNAGPGSVAG LYVNNKHFNR LPGLSGWFSS KKDKQFDMEH TLTAADHAGA YQIGTPHVLS 

       310        320        330        340        350        360 
IAPLIGSLEI FKDAGIERLR EKSLHITRYM LNLIDHELKD FGFTIGNPLE DESRGGHIYL 

       370        380        390        400        410        420 
EHAEAARICK ALKANGVIPD FRAPNGVRLA PVALYNTYEE VWKSVQILKG IMKEEKYKQF 


ENKREVVA 

« Hide

References

[1]Doggett N., Chertov O., Bruce D., Detter J.C., Johnson S.L., Han C.
Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HD-789 EMBL AFQ26456.1.
[2]"Complete Genome Sequence of Bacillus thuringiensis Serovar Israelensis Strain HD-789."
Doggett N.A., Stubben C.J., Chertkov O., Bruce D.C., Detter J.C., Johnson S.L., Han C.S.
Genome Announc. 1:e01023-13(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: HD-789 EMBL AFQ26456.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003763 Genomic DNA. Translation: AFQ26456.1.
RefSeqYP_006610376.1. NC_018508.1.

3D structure databases

ProteinModelPortalJ3UH26.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFQ26456; AFQ26456; BTF1_11305.
GeneID13501598.
KEGGbtn:BTF1_11305.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01556.

Enzyme and pathway databases

UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01970. Kynureninase.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameJ3UH26_BACTU
AccessionPrimary (citable) accession number: J3UH26
Entry history
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: March 19, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)