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J3UH26

- J3UH26_BACTU

UniProt

J3UH26 - J3UH26_BACTU

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Protein
Kynureninase
Gene
kynU, BTF1_11305
Organism
Bacillus thuringiensis HD-789
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei105 – 1051Pyridoxal phosphate By similarityUniRule annotation
Binding sitei213 – 2131Pyridoxal phosphate By similarityUniRule annotation
Binding sitei216 – 2161Pyridoxal phosphate By similarityUniRule annotation
Binding sitei238 – 2381Pyridoxal phosphate By similarityUniRule annotation
Binding sitei267 – 2671Pyridoxal phosphate By similarityUniRule annotation
Binding sitei295 – 2951Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
ORF Names:BTF1_11305Imported
OrganismiBacillus thuringiensis HD-789Imported
Taxonomic identifieri1217737 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000005257: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliJ3UH26.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1354Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

J3UH26-1 [UniParc]FASTAAdd to Basket

« Hide

MYKEPFQPTY EYALECDKHD ELKDFQTEFY KKEGTIYLDG NSLGLLSKRA    50
EKSLLTLLDS WKEYGIDGWT EGEHPWFFLS EKLGKLTAPL IGALPEETIV 100
TGSTTTNIHQ VIATFYEPKG IRTKILADEL TFPSDIYALQ SQIRLKGLDP 150
DEHLVRVKSR DGRTLSEEDI IHAMEDDIAL ILLPSVLYRS GQILDMKRLT 200
TEAHKRDIHI GFDLCHSIGS IPHHFKDWDV DFAVWCNYKY LNAGPGSVAG 250
LYVNNKHFNR LPGLSGWFSS KKDKQFDMEH TLTAADHAGA YQIGTPHVLS 300
IAPLIGSLEI FKDAGIERLR EKSLHITRYM LNLIDHELKD FGFTIGNPLE 350
DESRGGHIYL EHAEAARICK ALKANGVIPD FRAPNGVRLA PVALYNTYEE 400
VWKSVQILKG IMKEEKYKQF ENKREVVA 428
Length:428
Mass (Da):48,697
Last modified:October 31, 2012 - v1
Checksum:iF67770C7C10FA1CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003763 Genomic DNA. Translation: AFQ26456.1.
RefSeqiYP_006610376.1. NC_018508.1.

Genome annotation databases

EnsemblBacteriaiAFQ26456; AFQ26456; BTF1_11305.
GeneIDi13501598.
KEGGibtn:BTF1_11305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003763 Genomic DNA. Translation: AFQ26456.1 .
RefSeqi YP_006610376.1. NC_018508.1.

3D structure databases

ProteinModelPortali J3UH26.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFQ26456 ; AFQ26456 ; BTF1_11305 .
GeneIDi 13501598.
KEGGi btn:BTF1_11305.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Bacillus thuringiensis Serovar Israelensis Strain HD-789."
    Doggett N.A., Stubben C.J., Chertkov O., Bruce D.C., Detter J.C., Johnson S.L., Han C.S.
    Genome Announc. 1:e01023-13(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HD-789Imported.

Entry informationi

Entry nameiJ3UH26_BACTU
AccessioniPrimary (citable) accession number: J3UH26
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 3, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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